Search Studies
Studying a New Medicine to Help People with Type 2 Diabetes Lose Weight and Manage Blood Sugar
The purpose of this study is to see if a new medicine can help people with type 2 diabetes who are overweight or obese lose weight safely and better manage their blood sugar. Our researchers will compare the new medicine to a placebo (looks the same, but does not have medicine in it) to see how well it works and if it is safe. The medicine will be given along with a healthy eating and increased physical exercise program.
Study Topics
Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
Study Topics
Studying a New Way to Prevent Blood Clots During Medical Procedures
The goal of this study is to help people who need medical procedures where their blood goes outside their body, like during dialysis or heart surgery. We want to find a way to stop blood clots during these procedures. This study will help us learn how to prevent clots and make these procedures safer. We are looking for healthy volunteers, both adults and children, who are 17-70 years old and weigh over 110 pounds.
Study Topics
Studying a New Medicine to Help People with COPD
The goal of this study is to see if a new medicine called lunsekimig can help people with COPD feel better. It will look at how well the medicine works for people who still have breathing problems even though they are already getting treatment. The study will also check if the medicine causes any side effects.
Study Topics
Studying a New Medicine for People with Heart Disease and Obesity
Atherosclerotic cardiovascular disease happens when fatty buildup blocks blood vessels and makes it harder for blood to flow. The purpose of this study is to learn more about a new medicine for people who already have this condition and are overweight or have obesity. The goal is to see if the medicine can help lower their chances of having heart problems in the future.
Study Topics
Using Brain Scans to Track Brain Tumor Changes
The purpose of this study is to learn if special brain scans can give doctors better information about how brain tumors change over time. We will compare regular MRI scans with special MRI scans and, for some people, a PET scan. What we learn may help doctors care for future patients with brain cancer. This study is for volunteers diagnosed with glioblastoma.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying the Medicine VX-670 for Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 is a disease that makes muscles weak and hard to relax, and it can also affect other parts of the body like the heart and stomach. The purpose of this study is to see if a new medicine is safe and works well for people with this disease. Our researchers will see if the medicine can help with muscle problems and check for any side effects over two years.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Learning How the Brain Shifts Attention
The purpose of this study is to learn how people move their attention when they see different things. We will use computer tasks and brain scans to see how your brain works when you pay attention to new things. The goal is to help scientists understand how attention changes in the brain.
Study Topics
Studying a New Device for Women with Overactive Bladder Symptoms
Overactive bladder is a health problem that makes it hard for a person to hold their urine and causes them to feel a strong need to go to the bathroom often. This study will see if a new device can help women with this problem. The device uses gentle heat to try to fix the nerves that cause these issues. Researchers will check if the device works better than no treatment.
Study Topics
Studying the Medicine Depemokimab for COPD
Chronic obstructive pulmonary disease (COPD) is a lung disease that makes it hard to breathe because the airways are swollen and narrow. The purpose of this study is to learn more about a new medicine called depemokimab for people with COPD. Our researchers will compare it to a placebo (inactive shot) to see if it is safe and helps reduce flare-ups. The goal is to see if this medicine can help people breathe better and feel better.
Study Topics
Improving Sleep and Cognitive Health for People with Depression
The goal of this study is to see if improving sleep at night can help people with depression. Volunteers in this study will wear a headband while they sleep that is designed to improve deep sleep, the part of sleep that is important for healthy brain function. We hope that improved sleep can help with mood, memory, and attention. This study will involve three in-lab visits and will last about three weeks. Volunteers must be diagnosed with Major Depressive Disorder (MDD) and have some concerns about their memory or attention.
Study Topics
Development of a Tool to Help Caregivers Check Car Seat Installation
The purpose of this study is to create a tool that can use a short phone video to check if a child's car seat is installed correctly. Many car seats are not used the right way, even though most parents think they are. We are looking for parents and caregivers of children who ride in forward-facing car seats to help us build this tool. If you join, we will record short videos of your car seat before and after a free safety check by a certified child passenger safety technician with and without your child in the car seat.
Study Topics
Screening and Prevention Other Children, Infants, Teen Health
Helping Young People Manage Sickle Cell Pain
The purpose of this study is to see how Cognitive Behavioral Therapy (CBT) helps with pain in people who have sickle cell disease. We also want to see if self-guided CBT or CBT with the help of a health coach is better. In this study, a health coach is a peer or someone who is either living with or a caregiver of someone living with sickle cell disease.
Study Topics
Studying How Stress Affects Health in People Living with HIV
Many people living with HIV disease have stress in their lives that can negatively affect their health. The goal of this study is to understand how long-term stress changes how our brain and immune systems work. We also want to see how these changes affect our feelings, thoughts, and actions. By learning this, we hope to create better treatments for problems like depression and drug use. The study is open to individuals living with HIV.
Study Topics
Improving Physical Function in Older Adults with Kidney Disease
The purpose of this study is to find out if two different programs can help older people with chronic kidney disease. One program involves exercise with quick movements 3 times per week for 12 weeks, and the other program involves taking classes on how to live a healthy lifestyle once per week for 12 weeks. Our researchers want to see if older people enjoy these programs and if they can be done safely. We are looking for volunteers who live within 20 miles of the Reynolda Campus.
Study Topics
Studying the Medicine Axatilimab for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease is when the new cells from a transplant attack the patient's body and cause serious health problems. The purpose of this study is to find out if a new medicine called axatilimab, given with steroids, helps people with this disease.
Study Topics
Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
Study Topics
Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Studying a New Hepatitis B Blood Test
The purpose of this study is to find out how well a new rapid blood test can detect hepatitis B infection. Researchers will compare the test results to standard laboratory testing to see how accurate and easy the test is to use in healthcare settings. This study is for volunteers who are experiencing signs or symptoms that may be related to hepatitis and have a history of factors that may increase the chance of hepatitis B infection.
Study Topics
Can Vibegron Improve Health in Older Adults With Obesity?
This study is testing whether an FDA-approved medication called vibegron can improve energy use, physical function, memory, and overall health in adults ages 50 to 70 who have obesity. Researchers will compare vibegron to a placebo to learn if it may help reduce health problems linked to aging and obesity.
Study Topics
Finding and Treating Early Heart Artery Plaque
The purpose of this study is to find adults who may have early plaque buildup in their heart arteries before they develop heart disease symptoms. Researchers also want to learn whether lifestyle support and study medicines can help slow or reduce plaque buildup over time. This study is for men ages 30 to 50 or women ages 40 to 60 with low 10-year risk of heart disease with several risk factors or known calcified plaque.
Study Topics