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Studying Risk Factors for Type 2 Diabetes in Youth
Type 2 diabetes is a health problem where the body has too much sugar in the blood. This study wants to find out what makes young people more likely to get this condition early. The information we learn will help us create future studies on how to stop and treat type 2 diabetes in young people.
Study Topics
Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
Study Topics
Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
Study Topics
Studying the Medicine BMS-986482 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine BMS-986482. We want to see if this medicine is safe and works well for patients with certain types of cancer including non-small cell lung cancer, melanoma, colorectal cancer, breast cancer, urothelial cancer, prostate cancer, head and neck cancer or gastric cancer. We will compare this medicine alone or with other approved cancer medicines.
Study Topics
Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Head, Neck Cancer: Lung Cancer: Prostate Cancer: Skin Cancer: Stomach and Intestines Cancer: Urinary and Bladder
A Study of the Drug Tirabrutinib for Patients with Primary Central Nervous System Lymphoma
Primary Central Nervous System Lymphoma is a rare cancer that occurs within tissues of the brain or the spinal cord. The purpose of this study is to learn more about the study drug Tirabrutinib. We want to see if this study drug is a safe and works well for patients with this type of cancer.
Study Topics
A Study of the VBX Device for Patients with Peripheral Artery Disease
The purpose of this study is to learn more about the VBX Stent Graft study device. We want to see if the study device is safe and works well for patients with complex iliac occlusive disease, a form of peripheral artery disease. We will compare this study device to another device called Bare Metal Stents and see which one will work better.
Study Topics
Testing a New Study Device for Tricuspid Regurgitation
The purpose of this study is to test a study device called Edwards EVOQUE system for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
A Study of the Drug Staccato Alprazolam for Patients with Prolonged Seizures
The purpose of this study is to learn more about the study drug Staccato Alprazolam. We want to see how well the study drug works for treating patients with previous episodes of prolonged seizures. We also want to learn more about the safety and side effects that may be caused by the study drug.
Study Topics
A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about the study drug ABBV-525. We want to see if this study drug is safe and useful for the treatment of B-cell non-Hodgkin's Lymphoma that has returned or is not responding to current treatment. We also want to learn about the side effects that may be caused by taking this drug.
Study Topics
Increasing Appetite in Cancer Patients
This purpose of this study is to see if the study drug, olanzapine, can help cancer patients feel hungrier and help them gain weight. We want to see if olanzapine is better than the usual treatment.
Study Topics
Studying a New Study Catheter to Treat Rapid Heartbeat
The purpose of this study is to learn more about a new study catheter. We want to see if this catheter can help treat episodes of rapid heartbeat in patients with heart problems not caused by blocked arteries or heart attacks. We want to learn more about the safety and effectiveness of this catheter.
Study Topics
Using Upadacitinib to Treat Arthritis in Children and Young People
The purpose of this study is to learn more about treating arthritis in children and young people with the study drug, upadacitinib. We want to see if this treatment works better than the usual treatment.
Study Topics
Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Using Mavacamten to Treat Adolescents with Cardiomyopathy
Obstructive Hypertrophic Cardiomyopathy (HCM) is a heart condition that makes it hard for the heart to pump blood and may make a person feel weak and tired. The purpose of this study is to see if the study drug, mavacamten, helps young people with obstructive HCM.
Study Topics
Testing a Study Device for Treatment of Sudden Tear in the Aorta
The purpose of this study is to find out if the study device called AMDS is safe and works well for treating this condition. We want to see if this device can help heal the aorta's walls and reduce the need for surgery.
Study Topics
Studying a New Pneumococcal Disease Vaccine Among Healthy Toddlers
Your child is being asked to join this study because they are healthy, between 12 to 15 months old, and have had 3 doses of Prevnar 20®. The study will test a new vaccine to see if it can protect against a germ that causes infections in children. The goal is to check if the vaccine is safe and helps the body make antibodies to fight the germ.
Study Topics
Healthy Volunteers Infectious Diseases Screening and Prevention Children, Infants, Teen Health
Using the GORE® Device to Treat Heart Lesions
Aortic disease may cause wounds in the blood vessels near the heart. We want to learn more about the safety and how well the study device, GORE® Ascending Stent Graft, treats these wounds.
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Finding out if Antiviral Medicine Worked for Babies or Toddlers with Cytomegalovirus Infection
The purpose of this study is to learn more about the treatment with antiviral medicine for babies born with cytomegalovirus. We want to see if antiviral medicine has any impact on hearing, cancer risk, overall growth, or sexual development.
Study Topics
Infectious Diseases Children, Infants, Teen Health Ears, Nose, Throat, Mouth
Learning More About Speech Profiles after a Stroke
The purpose of this study is to learn more about speech profiles among stroke survivors and healthy volunteers. Understanding more about speech profiles can help customize treatment.
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Collecting Data for Parkinson's Disease Research
The purpose of this study is to gather information on people with Parkinson's disease through a patient registry. The registry will collect genetic information from people with Parkinson's, those at risk, and others without the disease. The registry will help improve understanding and care for Parkinson's disease.
Study Topics