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Studying a New Medicine to Treat BK Virus Infection
The purpose of this study is to test a new medicine called AIC263029 to see if it can help treat BK virus infection in people who have had a kidney transplant. They want to learn how well the medicine works and how safe it is. The information from this study may help improve treatment for people with BK virus in the future.
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Testing a New Treatment for Myeloproliferative Disorders
The purpose of this study is to see how well the study drug, INCA033989, works for treating myeloproliferative disorders. We want to find what effects, if any, this therapy may have on people. We also want to find out what is the highest dose that can be given without causing severe side effects.
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Tracking Asthma Treatment With Depemokimab in Everyday Life
This study is for adults with asthma caused by type 2 inflammation who are starting depemokimab as part of their regular care. Researchers want to learn how well depemokimab works in everyday healthcare settings and how it affects asthma symptoms, asthma attacks, quality of life, and healthcare use over time.
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Studying the Medicine KQB54 for Previously Treated Pancreas, Colon, or Non-Small Cell Lung Cancer that Has Spread
The purpose of this study is to learn more about a medicine called KQB548. Our researchers want to see if the medicine can safely help people with an advanced solid tumor that has a KRAS G12D mutation. They also want to learn if the medicine is safe and find the best dose to use, while also seeing how it affects cancer growth.
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Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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How Cancer Treatment May Affect Brain Health
This study is looking at whether a cancer medicine called bevacizumab may cause small changes in the brain by raising blood pressure. Researchers will use brain scans and blood pressure checks to learn more about brain health in older adults with cancer. This study is for adults 60 and older diagnosed with gynecologic or colorectal cancer who are planning to receive bevacizumab as part of their cancer treatment.
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Studying Two Treatments for Early Stage Breast Cancer
The purpose of this study is to learn more about adding chemotherapy to hormone treatment for breast cancer. We will compare two common treatments to see which works better. The goal is to find out if adding chemotherapy can prevent the cancer from returning and learn more about the possible side effects. We are looking for volunteers who have early-stage breast cancer, are HER2-negative, and have not gone through menopause yet.
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Studying a New Medicine for CIDP Nerve Disease
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a nerve disease that causes weakness and numbness. The purpose of this study is to learn more about a new medicine called TAK-881 for this disease. Everyone in the study will get TAK-881, and doctors will compare it to another medicine called HYQVIA. The goal is to find out if TAK-881 works better or is easier to use.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Study of DSP-5336 for Treatment of Leukemia
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
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Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
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Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
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Cancer Cancer: Children, Teens Children, Infants, Teen Health
Understanding Pregnancy Experiences After Weight Loss Treatment
The purpose of this study is to learn how healthcare can better support women who are pregnant after weight loss treatment. We want to understand their goals for pregnancy and the challenges they may face. This study is for women in or near their third trimester who have had weight loss surgery or have taken a GLP-1 medicine in the past.
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Opinions, Social Issues Weight, Metabolism, Nutrition Women's Health
Comparing Metformin and Insulin for Gestational Diabetes
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
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Learning About Experiences with Healthcare to Improve Community Health
The purpose of this study is to help improve community health. Our researchers want to learn about people’s experiences with healthcare, especially for those who use substances. Sharing your story can help improve care and support for others in your community. This study is for volunteers who have used stimulants or opioids in the past year.
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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Women's Health and Future Pregnancies
The goal of this study is to learn how a woman's health, including what she eats and the activities she does, affects her and her baby if she gets pregnant. We are inviting women under 40 who are overweight or obese and might become pregnant to volunteer for this study. The study team will provide more details.
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Healthy Volunteers Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
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Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
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Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
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