Treating Low-Risk, Early Stage Breast Cancer with Hormonal Therapy
The usual treatment for low-risk breast cancer is radiation and hormonal therapy. The purpose of this study is to find out how well hormonal therapy alone will work. We want to find out if this approach is better or worse than the usual approach.
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Testing the Study Drug CB-011 for Treatment of Multiple Myeloma
The purpose of this study is to learn more about the study drug CB-01. We want to see if it is safe and helpful for treating people with a type of blood cancer called multiple myeloma that has come back or did not respond to other treatments. This drug uses special cells from a healthy donor to find and kill cancer cells.
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Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Graft-versus-host disease happens when the new cells from a stem cell transplant attack the patient's own body cells. This study aims to learn more about a new medicine called ruxolitinib to prevent this disease after a stem cell transplant. We will compare this medicine to the standard treatment. Volunteers must be planning to undergo a stem cell transplant for leukemia or lymphoma. The study team will provide more information.
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A Study of the Drug Tirabrutinib for Patients with Primary Central Nervous System Lymphoma
Primary Central Nervous System Lymphoma is a rare cancer that occurs within tissues of the brain or the spinal cord. The purpose of this study is to learn more about the study drug Tirabrutinib. We want to see if this study drug is a safe and works well for patients with this type of cancer.
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Treating Ovarian Cancer with Avutometinib and Defactinib
The purpose of this study is to compare the combination of the study drugs, avutometinib and defactinib, to the usual treatment for a type of cancer called low grade serous ovarian cancer.
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A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about the study drug ABBV-525. We want to see if this study drug is safe and useful for the treatment of B-cell non-Hodgkin's Lymphoma that has returned or is not responding to current treatment. We also want to learn about the side effects that may be caused by taking this drug.
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Increasing Appetite in Cancer Patients
This purpose of this study is to see if the study drug, olanzapine, can help cancer patients feel hungrier and help them gain weight. We want to see if olanzapine is better than the usual treatment.
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A Study of the Drug AZD5492 for Blood Cancer
The purpose of this study to learn more about the study drug AZD5492. We want to see if this study drug is safe and helpful for treating blood cancers that have not gotten better with other treatments. We need volunteers with certain types of blood cancer like B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma. The study team will provide more information.
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Learning More About Using ABBV-383 to Treat Amyloidosis
The purpose of this study is to find out how safe and effective the study drug, ABBV-383, is in treating people with with amyloidosis.
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Testing a New Drug Combination for Patients with Myelofibrosis
The purpose of this study is to learn more about using two drugs called navtemadlin and ruxolitinib. We want to see if taking both drugs together helps treat patients with myelofibrosis. We also want to see if people can handle taking the drugs.
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Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
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Learning More About Using Ivonescimab to Treat Lung Cancer
The purpose of this research study is to see if the study drug, ivonescimab, is safe and useful to treat people with a type of cancer called metastatic squamous non-small cell lung cancer.
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Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
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Studying a New Cell Therapy for Patients with Newly Diagnosed Multiple Myeloma
The purpose of this study is to learn more about a cell therapy called Cilta-cel. This type of treatment changes the white blood cells to help treat multiple myeloma. We want to see if this type of treatment works better than the usual treatment for patients with Multiple Myeloma.
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Using the Study Drugs Atezolizumab and Bevacizumab to Treat Liver Cancer
The study wants to learn more about a drug called Atezolizumab. We want to see how well it treats liver cancer by itself and when used with another drug called Bevacizumab. We also want to know if these treatments are better or worse than the usual treatment. Volunteers must have advanced liver cancer that can't be removed by surgery.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Testing Study Drugs for Advanced Solid Tumors
The purpose of this study is to learn more about study drugs to help treat patients with advanced solid tumors. The study drugs being tested are GSK4381562, dostarlimab and belrestotug. We will try different combinations of these drugs to see if they are safe and work well.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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