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Comparing Hearing Loss in Cancer Patients
The main goal of this study is to find out if there is a difference in hearing loss between cancer patients who get the treatment cisplatin and those who get the treatment carboplatin. We want to know how hearing loss affects patients in their daily lives. To find out, we will make a questionnaire that asks about your own experiences with hearing loss or hearing problems. We are looking for volunteers with germ cell tumors who have been treated with either cisplatin or carboplatin.
Study Topics
Cancer Cancer: Children, Teens Cancer: Rare Cancers Cancer: Solid Tumor
Comparing Chemotherapy Schedules for Germ Cell Tumors
The purpose of this study is to find out if giving chemotherapy drugs on a faster schedule helps patients with advanced germ cell tumors. We will compare the regular 3-week cycle with a faster paced 2-week cycle. We want to see if the faster schedule is useful and safe for the patients.
Study Topics
Improving Cancer Care for Young Patients
The purpose of this study to find better ways to diagnose, treat, and prevent cancers in children, teenagers, and young adults. Our goal is to gather information about cancer treatments and their results to improve future care. We are looking for volunteers who have cancer or other conditions where cells grow abnormally. The study team will provide more details.
Study Topics
Comparing a New Treatment For Blood Cancer Patients
The purpose of this study is to learn about a new treatment called Inotuzumab Ozogamicin. We want to see if it helps people with blood cancer. We will compare the results of patients who get this new treatment with those who get the usual treatment. We are looking for volunteers who are newly diagnosed with one of these blood cancers: high-risk B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia (MPAL), or disseminated B lymphoblastic lymphoma (B-LLy).
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Cancer: Leukemia
Studying a New CAR T Treatment for Multiple Myeloma
The purpose of this study is to learn more about a new treatment called arlo‑cel for people with multiple myeloma. The study will compare this new treatment to standard cancer medicines to see which works better and is safer. This study is for volunteers with multiple myeloma whose cancer came back or did not improve after other treatments.
Study Topics
Studying a New CAR T Treatment for Multiple Myeloma
This study aims to learn what young people with cancer need most while getting care and after treatment. We want to understand what topics they want more education and support about, such as health, emotions, and daily life. What we learn will help improve programs and services for young people with cancer. We are looking for volunteers who were between 15 and 39 years old when they were diagnosed with cancer and are currently getting cancer treatment or have had cancer treatment in the past.
Study Topics
Comparing Two Medicines for ALK‑Positive Lung Cancer
The purpose of this study is to learn more about a new medicine called NVL‑655 for non‑small cell lung cancer that is ALK‑positive. Our researchers want to see if NVL‑655 works better and is safer than a commonly used medicine called alectinib. The goal is to learn which treatment helps stop the cancer from getting worse for a longer time.
Study Topics
Mobile App Support for Young Women with Breast Cancer
The purpose of this study is to look at a new way to better support young women with breast cancer. Our researchers will look at whether a mobile app can provide support and help lower stress. The app lets women connect with others and learn helpful information. This study is for volunteers who have been diagnosed with breast cancer at any stage.
Study Topics
Testing a New Targeted Cancer Medicine for Gastrointestinal Stromal Tumors (GIST)
The purpose of this study is to learn more about a study drug called IDRX-42 (GSK6042981). We want to see if IDRX-42 works better than sunitinib, a medicine used to treat a type of cancer called gastrointestinal stromal tumor (GIST). This study is for people whose cancer has grown after treatment with imatinib or who had side effects that made it hard to take imatinib. Researchers will also learn more about the safety of IDRX-42 and how it affects people's symptoms and daily life. This information may help doctors find better treatments for people with GIST in the future. Volunteers must be adults with GIST that has spread to other parts of the body or cannot be removed with surgery. They must have received treatment with imatinib in the past. The study team will provide more information
Study Topics
Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
Study Topics
Studying a Type of Blood Test Used to Find Cancer in People With Sarcoma
The purpose of this study is to look at how well a special blood test called LP-WGS can find cancer in people with bone or soft tissue sarcoma (a type of cancer).
Study Topics
Helping Young Cancer Survivors Feel Better Using a Digital Tool
The purpose of this study is to learn more about a new digital tool to help adolescents and young adult cancer survivors manage their symptoms of depression. People in the study will use the tool, answer questions, and join a video call. The goal is to find out if the tool helps them manage their feelings better. All study visits and consultations will be done virtually.
Study Topics
Mental Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
Study Topics
Communities Against Cancer: A Survey for Change
The purpose of this study is to learn about how people in our area take care of their health and what challenges they face with cancer. We hope to understand what people need and how we can help them better. The answers from this survey will help us make plans to support our community.
Study Topics
Men's Health Opinions, Social Issues Screening and Prevention Wellness and Lifestyle Women's Health Cancer Other
Studying New Medicine and Chemo for Rare Throat Cancer
The purpose of this study is to see if adding a new medicine called nivolumab to regular chemotherapy helps treat a rare throat cancer called nasopharyngeal carcinoma. We will also look at whether children can get less radiation and have fewer side effects. The goal is to find safer and better ways to treat this cancer.
Study Topics
Cancer Cancer: Children, Teens Cancer: Ear, Nose, Mouth, Throat
Studying a New mRNA Medicine for Blood Cancer
The purpose of this study is to learn more about a new medicine called mRNA-2808 for people with multiple myeloma, a type of blood cancer. This medicine helps teach your immune system how to find and kill cancer cells. The goal is to see if the medicine is safe and to find the best dose. Researchers will also study how it affects the cancer and the body.
Study Topics
Studying a New Medicine for a Rare Blood Cancer - Chronic Myeloid Leukemia (CML)
The purpose of this study is to learn more about a medicine for a rare blood cancer called chronic myeloid leukemia. We want to see if the medicine TERN-701 can safely stop or slow down cancer. This study is for patients with chronic myeloid leukemia (CML) who have already tried other treatments that did not work or caused problems.
Study Topics
Studying New Treatments for Multiple Myeloma That Came Back
The purpose of this study is to find better ways to treat a type of cancer called multiple myeloma. We want to see if using different mixes of medicines works better than the usual treatment for people whose cancer came back or did not get better with other treatments. We also want to learn which medicines help the most, and check for any side effects to make sure the treatments are safe.
Study Topics
Comparing Two Medicines for CLL and SLL Blood Cancer
The purpose of this study is to see how two different medicines work for people with a type of blood cancer called CLL or SLL. We will compare how safe the medicines are and how well they help control the cancer. Our researchers hope to find out which medicine works better for people whose cancer has already been treated.
Study Topics
Studying a Treatment for Weight Loss in Pancreatic Cancer
The purpose of this study is to learn more about the study medicine called ponsegromab. We want to see if it can help adults with pancreatic cancer that has spread who have lost weight and strength because of their cancer. Researchers will compare ponsegromab to a placebo to see if it helps improve body weight, appetite, fatigue, and quality of life.
Study Topics
Weight, Metabolism, Nutrition Cancer Cancer: Kidney, Liver, Pancreas