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Comparing Hearing Loss in Cancer Patients
The main goal of this study is to find out if there is a difference in hearing loss between cancer patients who get the treatment cisplatin and those who get the treatment carboplatin. We want to know how hearing loss affects patients in their daily lives. To find out, we will make a questionnaire that asks about your own experiences with hearing loss or hearing problems. We are looking for volunteers with germ cell tumors who have been treated with either cisplatin or carboplatin.
Study Topics
Cancer Cancer: Children, Teens Cancer: Rare Cancers Cancer: Solid Tumor
Comparing a New Treatment For Blood Cancer Patients
The purpose of this study is to learn about a new treatment called Inotuzumab Ozogamicin. We want to see if it helps people with blood cancer. We will compare the results of patients who get this new treatment with those who get the usual treatment. We are looking for volunteers who are newly diagnosed with one of these blood cancers: high-risk B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia (MPAL), or disseminated B lymphoblastic lymphoma (B-LLy).
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Cancer: Leukemia
Comparing Chemotherapy Schedules for Germ Cell Tumors
The purpose of this study is to find out if giving chemotherapy drugs on a faster schedule helps patients with advanced germ cell tumors. We will compare the regular 3-week cycle with a faster paced 2-week cycle. We want to see if the faster schedule is useful and safe for the patients.
Study Topics
Improving Cancer Care for Young Patients
The purpose of this study to find better ways to diagnose, treat, and prevent cancers in children, teenagers, and young adults. Our goal is to gather information about cancer treatments and their results to improve future care. We are looking for volunteers who have cancer or other conditions where cells grow abnormally. The study team will provide more details.
Study Topics
Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
Study Topics
Using Selinexor to Treat Endometrial Carcinoma
The purpose of this study is to find out if the study drug, selinexor, is safe and effective for treating a type of cancer called endometrial carcinoma.
Study Topics
Studying the Drug JNJ 88549968 for Patients with Myeloproliferative Neoplasms
Myeloproliferative neoplasms are blood cancers caused by changes in bone marrow cells. This study aims to learn more about the drug JNJ-88549968 to treat these cancers. We want to find a safe dose and see how long it stays in the body and how the body reacts to it.
Study Topics
Treating Vulvar Dysplasia with a New Surgical Treatment
This study is being done to see if a surgical treatment, Frozen-Section Directed Excision, is better at treating vulvar dysplasia than the usual treatment.
Study Topics
Studying the Drug JNJ-90014496 for Patients with B Cell Non-Hodgkin Lymphoma
This study aims to learn more about the drug JNJ-90014496. We want to see if this drug is safe and helpful for treating patients with B cell Non-Hodgkin Lymphoma that has come back or hasn't responded to treatment.
Study Topics
A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
Study Topics
Testing a New Drug System Called TAR-210 for Bladder Cancer
The purpose of this study is to learn more about a drug system called TAR210. We want to see if this drug system works better than regular bladder cancer. This study is for patients with a type of bladder cancer called Intermediate-Risk Non-Muscle-Invasive Bladder Cancer that has changes in a gene called FGFR.
Study Topics
Comparing Multi-day Versus Single Day Radiation Therapy for Brain Cancer
This study aims to find out if giving radiation over several days causes fewer side effects than giving it in one day for brain cancer patients on immunotherapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Breast Cancer: Kidney, Liver, Pancreas Cancer: Lung Cancer: Skin
Studying a New Medicine for Advanced Prostate Cancer
The purpose of this study is to learn more about a new medicine called xaluritamig. We want to see if this medicine works better than the current treatment for prostate cancer that has spread and no longer responds to hormone therapy. Volunteers in the study will get either the new medicine or one of the standard treatments. Doctors will check how long people live and how well they do with each treatment.
Study Topics
Comparing Two Medicines for Essential Thrombocythemia
The purpose of this study is to see if a new medicine called bomedemstat is safe and works well for people with a blood disease called essential thrombocythemia. We will compare bomedemstat to another medicine called hydroxyurea. The goal is to find out which medicine helps more with symptoms like tiredness and high platelet counts.
Study Topics
Studying the Medicine NBTXR3 for Head and Neck Cancer
The purpose of this study is to find out if a new medicine, given with radiation, helps people with head and neck cancer who cannot get certain chemotherapy. The study will also check if the medicine is safe. Doctors will compare the new medicine plus radiation to radiation alone.
Study Topics
Studying the Medicine BMX-001 to Reduce Mouth Sores in Head and Neck Cancer
The purpose of this study is to learn more about the medicine BMX-00. We want to see if adding this medicine to usual chemotherapy and radiation can help lower the chance or severity of mouth sores and pain in people with head and neck cancer. People in the study will get either BMX-001 or a placebo, along with their regular treatment. The goal is to see if BMX-001 works better than the usual care for these side effects.
Study Topics
Learning More about Immunotherapy Before and After Skin Cancer Surgery
The purpose of this study is to learn about a new way to treat skin cancer with surgery. We want to see if giving a type of medicine called immunotherapy before and after surgery helps people stay cancer-free longer than the usual treatment. We are trying to find out if this new way works better or worse than the regular way. We are looking for volunteers who have a kind of skin cancer called cutaneous squamous cell carcinoma that can be removed with surgery.
Study Topics
Studying a Type of Blood Test Used to Find Cancer in People With Sarcoma
The purpose of this study is to look at how well a special blood test called LP-WGS can find cancer in people with bone or soft tissue sarcoma (a type of cancer).
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Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
Study Topics