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Testing the Study Drug CIN-102 for Diabetic Gastroparesis Treatment
The purpose of this study is to better understand how well the NeuroBlate System works for treating brain metastases. The system will be used along with laser interstitial thermal therapy (LITT). The NeuroBlate System uses laser light energy to heat and destroy the tumor. The LITT procedure includes a biopsy of brain tissue. The procedures are considered to be minimally invasive.
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Treating Low-Risk, Early Stage Breast Cancer with Hormonal Therapy
The usual treatment for low-risk breast cancer is radiation and hormonal therapy. The purpose of this study is to find out how well hormonal therapy alone will work. We want to find out if this approach is better or worse than the usual approach.
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Study to Find Out if the Study Drug, LN145, Works Well for Treating Nonsmall Cell Lung Cancer
The purpose of this study is to find out if the study drug, LN145, works well for treating nonsmall cell lung cancer.
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Comparing Two Different Methods of Surgery to Treat Osteosarcoma that Has Spread to the Lungs
The purpose of this study is to compare two different surgery methods for people with osteosarcoma that has spread to the lung. We want to find out which surgery method is better. One method is called open thoracic surgery. It is done through a single large cut between the ribs, opens the chest, and removes the cancer. The other method is called thoracoscopy. It is done through several small incisions and uses a small camera to help with removing the cancer. Both methods are considered standard treatment.
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Comparing Two Different Methods of Surgery to Treat Osteosarcoma that Has Spread to the Lungs
The purpose of this study is to compare two different surgery methods for people with osteosarcoma that has spread to the lung. We want to find out which surgery method is better. One method is called open thoracic surgery. It is done through a single large cut between the ribs, opens the chest, and removes the cancer. The other method is called thoracoscopy. It is done through several small incisions and uses a small camera to help with removing the cancer. Both methods are considered standard treatment.
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Learning Moe About Using Nivolumab for Treatment of Newly Diagnosed Primary Mediastinal B-cell Lymphoma
Primary mediastinal B-cell lymphoma (PMBCL) is a type of cancer in the upper chest between the lungs and behind the breastbone. The purpose of this study is to find out how well the study drug, nivolumab, works for treating PMBCL.
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Learning More About Treating Cancer Near the Spinal Cord with Radiosurgery and Pembrolizumab
The purpose of this study is to find out what effects pembrolizumab and radiosurgery may have on you and your cancer. We want to see if this treatment can reduce the size of cancer that has spread near the spinal cord. Radiosurgery involves radiation in a large dose to destroy your cancer. It does not involve cutting your tumor out.
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Brain Changes after Radiation Treatment for Glioma
Glioma is a type of brain cancer. The purpose of this study is to see if we can predict how brain function will change after radiation treatment for glioma. We will be doing PET scans and blood tests with glioma patients. A PET scan is a type of test that gives us images of your brain and can help detect certain diseases.
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Treating Endometrial Cancer by Targeting HER2 Proteins
Endometrial cancer is a type of cancer in the uterus. This study is being done to find out if we can lower the chance of endometrial cancer coming back by using drugs that target HER2 proteins. Those drugs will be given in addition to the usual chemo drugs.
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Finding Out How Well Adding a Third Medication to Treatment Works for Treating Advanced Rectal Cancer
The purpose of this study is to find out if we can increase the likelihood of your tumor disappearing by adding a third drug to the usual treatment. We want to find out if this approach is better or worse than the usual approach.
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Learning More About Treating T-cell Lymphoma with the Study Drug Duvelisib or Azacitidine
The purpose of this study is to learn more about treating peripheral T-cell lymphoma with the study drug Duvelisib or Azacitidine. One of the study drugs will be given along with the usual treatment. We want to see how well the combination treatment works. We also want to learn more about possible side effects.
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Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
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Looking at How Chemotherapy Effects Older Adults
The purpose of this study is to look at how chemotherapy effects older adults. We want to learn more about predicting chemotherapy side effects in older adults. We also want to see if chemotherapy causes changes in the body that are associated with aging.
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Learning More About Treating Multiple Myeloma with Talquetamab
The purpose of this study is to see how well the study drug, talquetamab, works for treating multiple myeloma. We want to find out if this approach is better than usual treatment.
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Looking at How Estrogen Deprivation Affects Heart Function in Breast Cancer Patients
The purpose of this study is to learn more about how near complete estrogen deprivation therapy effects the heart in breast cancer patients. We want to understand if this therapy changes how the heart works.
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Adding Tazemetostat to the Usual Treatment for Melanoma
The purpose of this study is to find out if the study drug, tazemetostat, can keep your melanoma from getting worse. We also want to see if the study drug alone is better or worse than adding the study drug to the usual treatment.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Learning More About Treating of Acute Graft Versus Host Disease with Itolizumab
The purpose of this study is to see how well the study drug, Itolizumab, works for treating acute graft vs host disease. We also want to learn more about side effects the study drug may cause.
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Learning More About Treating Glioma with the Study Drug OKN-007
The purpose of this study is to find out how well the study drug, OKN-007, works for treating glioma. We also want to determine what dose is safe and well tolerated.
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Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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