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Testing the Study Drug Levocarnitine to Prevent Liver Damage in Leukemia or Lymphoma Patients
The purpose of this study to learn more about the study drug Levocarnitine. We want to see if this study drug protects the liver from chemotherapy for leukemia or lymphoma.
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Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
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Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
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Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
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Learning More About Treating T-cell Lymphoma with the Study Drug Duvelisib or Azacitidine
The purpose of this study is to learn more about treating peripheral T-cell lymphoma with the study drug Duvelisib or Azacitidine. One of the study drugs will be given along with the usual treatment. We want to see how well the combination treatment works. We also want to learn more about possible side effects.
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Finding Ways to Improve Health for Older Adults with B-cell Non-Hodgkin Lymphoma or Multiple Myeloma
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
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Can Physical Activity Be Helpful for Lymphoma Patients During Treatment?
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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Learning More About Treating Hodgkin Lymphoma with Brentuximab Vedotin and Nivolumab
The purpose of this study is to learn more about treating Hodgkin lymphoma with brentuximab vedotin and nivolumab (Bv-NIVO). We want to see if this treatment works better than the usual treatment.
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Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Graft-versus-host disease happens when the new cells from a stem cell transplant attack the patient's own body cells. This study aims to learn more about a new medicine called ruxolitinib to prevent this disease after a stem cell transplant. We will compare this medicine to the standard treatment. Volunteers must be planning to undergo a stem cell transplant for leukemia or lymphoma. The study team will provide more information.
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A Study of the Drug Tirabrutinib for Patients with Primary Central Nervous System Lymphoma
Primary Central Nervous System Lymphoma is a rare cancer that occurs within tissues of the brain or the spinal cord. The purpose of this study is to learn more about the study drug Tirabrutinib. We want to see if this study drug is a safe and works well for patients with this type of cancer.
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A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about the study drug ABBV-525. We want to see if this study drug is safe and useful for the treatment of B-cell non-Hodgkin's Lymphoma that has returned or is not responding to current treatment. We also want to learn about the side effects that may be caused by taking this drug.
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A Study of the Drug AZD5492 for Blood Cancer
The purpose of this study to learn more about the study drug AZD5492. We want to see if this study drug is safe and helpful for treating blood cancers that have not gotten better with other treatments. We need volunteers with certain types of blood cancer like B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma. The study team will provide more information.
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Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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Testing the Study Drug PRO1160 for Advanced Kidney, Throat, and Blood Cancers
The purpose of this study is to learn more about the new drug PRO1160. We want to see if it is safe and helpful for treating patients with cancer that didn't fully respond to treatment or has come back. Volunteers must have kidney cancer, throat cancer, or a type of blood cancer called non-Hodgkin lymphoma.
Study Topics
Cancer Cancer: Ear, Nose, Mouth, Throat Cancer: Kidney, Liver, Pancreas Cancer: Lymphoma
Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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A Study of the Drug Odronextamab for Follicular Lymphoma
Follicular lymphoma is a kind of non-Hodgkin lymphoma. This study wants to learn more about the drug Odronextamab for this disease. We want to see if the drug is safe and okay for patients who haven't been treated before. We also want to find out about any side effects the drug might cause.
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Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
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Studying the Drug Glofitamab for Patients with Untreated Large B-Cell Lymphoma
The purpose of this study to learn more about the study drug Glofitamab. We want to see how safe and useful the study drug is for patients with large B-cell lymphoma who have not yet received treatment for it. We want to see how well this study drug works when used with other cancer drugs.
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Testing New Lymphoma Treatment Combinations
The purpose of this study is to test if different drug combinations are safe and work well for treating lymphoma. We want to see how your body processes these drugs and what effects they have on your cancer. We are testing two combinations: mosunetuzumab with CC-220 or CC-99282, and glofitamab with obinutuzumab and CC-99282. We will use different doses and schedules to see what works best.
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