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Studying the Drug MT-7117 for Patients with a Rare Blood Disorder
The purpose of this study is to learn more about the study drug MT-7117. We want to see if this study drug is useful for patients with a rare blood disorder called Erythropoietic Protoporphyria. We also want to see if this study drug is tolerable to take.
Study Topics
Studying the Drug Plozasiran for Patients with Severe Hypertriglyceridemia
Hypertriglyceridemia is when you have too much fat in your blood. This study wants to see if the drug plozasiran is safe and works well to lower this fat in people with severe hypertriglyceridemia.
Study Topics
Testing the Study Drug Plozasiran for People with Hypertriglyceridemia
Hypertriglyceridemia is a condition where you have a high level of fat in your blood. The purpose of this study is to learn more about the study drug plozasiran for this condition. We want to find out if this study drug is safe and if it can help lower the fat levels in your blood.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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Testing the Study Drug Inclisiran for Lowering Bad Cholesterol in Patients with Heart Disease
The purpose of this study is to learn more about the study drug Inclisiran. We want to see if this study drug is safe and useful for lowering bad cholesterol in patients with heart disease. We will compare using this study drug with usual care versus usual care alone.
Study Topics
Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
Study Topics
Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
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Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Can Physical Activity Be Helpful for Lymphoma Patients During Treatment?
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Learning More About the Effects of Very Low-Nicotine Cigarettes on the Heart
The purpose of this study is to learn more about the effects of very low-nicotine cigarettes on the heart.
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Heart Health Substance Use (Alcohol, Illegal Drugs, Tobacco)
Testing a New Study Device for Tricuspid Regurgitation
The purpose of this study is to test a study device called Edwards EVOQUE system for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
A Study of the VBX Device for Patients with Peripheral Artery Disease
The purpose of this study is to learn more about the VBX Stent Graft study device. We want to see if the study device is safe and works well for patients with complex iliac occlusive disease, a form of peripheral artery disease. We will compare this study device to another device called Bare Metal Stents and see which one will work better.
Study Topics
Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
Looking Into the Need of Blood Thinners as Treatment for Atrial Fibrillation
Blood thinning drugs are usually used to treat atrial fibrillation. Atrial fibrillation is when the heart has an irregular and often very fast heart rhythm. Blood thinners lower the risk of stroke but also increase the risk of bleeding. It may not be necessary for people who have short or infrequent atrial fibrillation to take blood thinners. The purpose of this study is to find out if it is safe to stop blood-thinning medication during long periods of normal heart rhythm.
Study Topics
Studying a New Study Catheter to Treat Rapid Heartbeat
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
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Using Mavacamten to Treat Adolescents with Cardiomyopathy
Obstructive Hypertrophic Cardiomyopathy (HCM) is a heart condition that makes it hard for the heart to pump blood and may make a person feel weak and tired. The purpose of this study is to see if the study drug, mavacamten, helps young people with obstructive HCM.
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Studying Causes of Heart Failure
This purpose of this study is to understand what causes heart failure. Some people with early-stage heart failure might not know they have it because they feel fine, while others may have many or few symptoms. We want to learn why some people get heart failure and how to better classify it for targeted treatments. We are recruiting volunteers with and without heart failure to learn more.
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Testing a Study Device for Treatment of Sudden Tear in the Aorta
The purpose of this study is to find out if the study device called AMDS is safe and works well for treating this condition. We want to see if this device can help heal the aorta's walls and reduce the need for surgery.
Study Topics
Testing a Study Device for Chronic Venous Insufficiency
Chronic venous insufficiency happens when blood gets stuck in the veins of the legs because the valves do not work right. This study wants to see if the study device Venclose™ digiRF™ Generator and its catheters are safe and good at treating this problem. We want to know if these devices can help fix the veins in the legs and stop them from leaking. The study will also check if the devices are safe to use.
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Comparing MitraClip and Surgery for Mitral Valve Repair
The purpose of this study is to test a study device called the MitraClipTM Device for patients with this condition and who are at moderate risk of surgery.
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Using the GORE® Device to Treat Heart Lesions
Aortic disease may cause wounds in the blood vessels near the heart. We want to learn more about the safety and how well the study device, GORE® Ascending Stent Graft, treats these wounds.
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