Search Studies
Studying a New Medicine for Severe Heart Failure
The purpose of this study is to find out if a new medicine called omecamtiv mecarbil can help people with serious heart failure. The medicine may help the heart pump better and lower the chance of problems like hospital visits or other serious health issues. We hope this research will help doctors treat heart failure in the future.
Study Topics
Studying Different Hemodialysis Treatment Schedules
This study is testing whether starting hemodialysis gradually, two times a week then increase to three times a week, instead of three times a week from the beginning, may help people who still have some kidney function stay well and improve their quality of life. Researchers want to learn if a treatment schedule based on each person's needs can help their overall well-being and quality of life. Participants with residual kidney function will be randomly assigned to either start hemodialysis two times a week and increase to three times a week when clinically needed, or receive the usual hemodialysis schedule of three times a week from the beginning. Researchers will compare the results of the two groups. Volunteers of this study will also have the option to join a separate heart health study that uses heart MRI scans and blood tests to see how different dialysis schedules may affect the heart.
Study Topics
Studying a New Medicine to Lower Bad Cholesterol
The purpose of this study is to learn more about a new medicine called AZD0780. We want to see if this medicine can lower bad cholesterol and help prevent heart attacks or strokes. This study is for volunteers with heart disease or who are at high risk of heart problems. The goal is to see if the new medicine works better than current treatments and is safe for patients.
Study Topics
Exercise and Coaching Program for People With Heart Failure
The purpose of this study is to learn how a group exercise and coaching program affects people with heart failure with preserved ejection fraction. Our researchers will look at whether this program is safe and if it can help people be more active, move more easily, and feel better in their daily lives. This study will also help researchers learn if this type of program is practical and helpful for future patients.
Study Topics
Learning About Research for High Cholesterol and Heart Health
The purpose of this study is to help people learn what it is like to take part in a research study. Volunteers will have the chance to visit a research site and learn about the types of tests and procedures that may be done before deciding if they want to join a future gene editing study. This study is for volunteers who may have, or be at risk for, heart or blood vessel disease caused by a buildup of fat and cholesterol in the arteries. They may also have high cholesterol or other high levels of fat in your blood that are not well controlled.
Study Topics
Studying a New Medicine for Certain Types of Heart Failure
The purpose of this study is to learn more about the study medicine called VS 041. We want to see if this medicine is safe for people with a certain type of heart failure called heart failure with preserved ejection fraction (HFpEF). Our researchers will also look at how this medicine affects blood markers linked to heart health. What we learn may help guide future treatments.
Study Topics
Study of Two Medicines for Diabetes, Blood Pressure, and Heart Disease
The purpose of this study is to find out if taking two medicines together helps people with type 2 diabetes, high blood pressure, and heart disease. Our researchers will compare the medicines to a look-alike pill with no medicine inside. The goal is to see if the medicines can lower the chance of serious health problems like heart attacks or strokes.
Study Topics
Studying Olpasiran to Prevent Heart Disease
The purpose of this study is to learn more about a medicine called olpasiran. Our researchers want to see if it can help prevent serious heart problems like heart attacks or strokes. This study is for volunteers with high levels of a blood substance called lipoprotein(a), which can raise the risk of heart disease. Our researchers will also check how safe the medicine is and how well people tolerate it.
Study Topics
Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
Study Topics
Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
Study Topics
Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying the Medicine Olpasiran to Help Heart Disease
The purpose of this study is to learn more about a medicine called olpasiran. Our researchers want to see if it can lower a type of cholesterol in the blood and reduce plaque in the heart's arteries. They also want to learn how safe the medicine is. This study is for volunteers with heart disease and high levels of lipoprotein(a) in their blood.
Study Topics
Studying a New Medicine for Heart and Lung Health
Pulmonary hypertension with heart failure with preserved ejection fraction (PH‑HFpEF) is a type of heart problem where the heart does not relax and fill with blood the way it should. This causes higher pressure in the blood vessels that go to the lungs, which can make breathing harder. The purpose of this study is to learn more about a new medicine called levosimendan by comparing it to a placebo, which is a pill with no medicine.
Study Topics
High Blood Pressure in Children and Teenagers
The purpose of this study is to understand what causes high blood pressure in young people. We also want to learn more about how high blood pressure can cause damage to the heart and kidneys.
Study Topics
Healthy Volunteers Heart Health Children, Infants, Teen Health
How Salt Affects Blood Pressure in Young Adults Who Were Born Prematurely
The purpose of this study is to learn about how salt in the diet affects blood pressure in young adults who were born prematurely. We also want to find out if the medication, allopurinol, can change how salt in the diet affects blood pressure.
Study Topics
Healthy Volunteers Heart Health Kidneys, Liver, Pancreas Children, Infants, Teen Health
Finding and Treating Early Heart Artery Plaque
The purpose of this study is to find adults who may have early plaque buildup in their heart arteries before they develop heart disease symptoms. Researchers also want to learn whether lifestyle support and study medicines can help slow or reduce plaque buildup over time. This study is for men ages 30 to 50 or women ages 40 to 60 with low 10-year risk of heart disease with several risk factors or known calcified plaque.
Study Topics
Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
Study Topics
Studying a New Medicine to Help People With ATTR Heart Disease
ATTR amyloidosis is a disease where a protein called transthyretin builds up in the body and causes problems, especially in the heart and nerves. The purpose of this study is to learn more about a new medicine called nucresiran to help people with this disease.
Study Topics
Tracking Heart Disease Care in ATTR-CM Patients
Transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) is a disease where a protein builds up in the heart and makes it harder for the heart to pump blood. This study aims to learn more about this heart condition and how it is treated in real life. Researchers will collect information from medical records and patient surveys over time. This may help improve care for people with this condition in the future. This study is for volunteers with ATTR-CM who have started treatment within the last 90 days.
Study Topics
Comparing Two Heart Devices for Heart Failure
This study will compare two different ways to pace the heart to treat heart failure. There are two ways doctors can place a heart wire to help treat heart failure. One method places the wire on the outside of the heart's lower left chamber and is the standard treatment used today. The other method places the wire in a different area inside the heart called the left bundle branch area. Researchers want to compare these two approaches to see how well they work.
Study Topics