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Studying a New Medicine to Lower Bad Cholesterol
The purpose of this study is to learn more about a new medicine called AZD0780. We want to see if this medicine can lower bad cholesterol and help prevent heart attacks or strokes. This study is for volunteers with heart disease or who are at high risk of heart problems. The goal is to see if the new medicine works better than current treatments and is safe for patients.
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Studying the Medicine Pelacarsen for Heart Disease and Cholesterol
The purpose of this study is to learn more about the medicine pelacarsen. We want to see if this medicine is safe and can help people with heart disease and high cholesterol. Our researchers will compare pelacarsen to a placebo to see if it lowers a type of cholesterol called lipoprotein(a). The goal is to learn if this medicine can help prevent heart problems in the future.
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Studying a New Medicine for Certain Types of Heart Failure
The purpose of this study is to learn more about the study medicine called VS 041. We want to see if this medicine is safe for people with a certain type of heart failure called heart failure with preserved ejection fraction (HFpEF). Our researchers will also look at how this medicine affects blood markers linked to heart health. What we learn may help guide future treatments.
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Study of Two Medicines for Diabetes, Blood Pressure, and Heart Disease
The purpose of this study is to find out if taking two medicines together helps people with type 2 diabetes, high blood pressure, and heart disease. Our researchers will compare the medicines to a look-alike pill with no medicine inside. The goal is to see if the medicines can lower the chance of serious health problems like heart attacks or strokes.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
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Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
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Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying a New Medicine for Heart and Lung Health
Pulmonary hypertension with heart failure with preserved ejection fraction (PH‑HFpEF) is a type of heart problem where the heart does not relax and fill with blood the way it should. This causes higher pressure in the blood vessels that go to the lungs, which can make breathing harder. The purpose of this study is to learn more about a new medicine called levosimendan by comparing it to a placebo, which is a pill with no medicine.
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Can Physical Activity Be Helpful for Lymphoma Patients During Treatment?
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Looking Into the Need of Blood Thinners as Treatment for Atrial Fibrillation
Blood thinning drugs are usually used to treat atrial fibrillation. Atrial fibrillation is when the heart has an irregular and often very fast heart rhythm. Blood thinners lower the risk of stroke but also increase the risk of bleeding. It may not be necessary for people who have short or infrequent atrial fibrillation to take blood thinners. The purpose of this study is to find out if it is safe to stop blood-thinning medication during long periods of normal heart rhythm.
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High Blood Pressure in Children and Teenagers
The purpose of this study is to understand what causes high blood pressure in young people. We also want to learn more about how high blood pressure can cause damage to the heart and kidneys.
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Healthy Volunteers Heart Health Children, Infants, Teen Health
How Salt Affects Blood Pressure in Young Adults Who Were Born Prematurely
The purpose of this study is to learn about how salt in the diet affects blood pressure in young adults who were born prematurely. We also want to find out if the medication, allopurinol, can change how salt in the diet affects blood pressure.
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Healthy Volunteers Heart Health Kidneys, Liver, Pancreas Children, Infants, Teen Health
Using Body Fat Images to Assess Health
The purpose of this study is to see if we can use medical images of fat throughout the body to assess your health status.
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Aging Healthy Volunteers Heart Health Weight, Metabolism, Nutrition
Studying a New Medicine for People with Heart Disease and Obesity
Atherosclerotic cardiovascular disease happens when fatty buildup blocks blood vessels and makes it harder for blood to flow. The purpose of this study is to learn more about a new medicine for people who already have this condition and are overweight or have obesity. The goal is to see if the medicine can help lower their chances of having heart problems in the future.
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Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
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Studying a New Medicine to Help People With ATTR Heart Disease
ATTR amyloidosis is a disease where a protein called transthyretin builds up in the body and causes problems, especially in the heart and nerves. The purpose of this study is to learn more about a new medicine called nucresiran to help people with this disease.
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Testing a New Study Device for Tricuspid Regurgitation
The purpose of this study is to test a study device called Edwards EVOQUE system for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
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Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
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A Study of the VBX Device for Patients with Peripheral Artery Disease
The purpose of this study is to learn more about the VBX Stent Graft study device. We want to see if the study device is safe and works well for patients with complex iliac occlusive disease, a form of peripheral artery disease. We will compare this study device to another device called Bare Metal Stents and see which one will work better.
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Studying a New Study Catheter to Treat Rapid Heartbeat
The purpose of this study is to learn more about a new study catheter. We want to see if this catheter can help treat episodes of rapid heartbeat in patients with heart problems not caused by blocked arteries or heart attacks. We want to learn more about the safety and effectiveness of this catheter.
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