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Learning More About Treating Multiple Myeloma with Talquetamab
The purpose of this study is to see how well the study drug, talquetamab, works for treating multiple myeloma. We want to find out if this approach is better than usual treatment.
Study Topics
Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
Study Topics
Treating Multiple Myeloma with a Combination of Talquetamab and Teclistamab
The purpose of this study is to learn more about how well the study drugs, talquetamab and teclistamab, work for treating multiple myeloma that has returned or been difficult treat. We also want to find out how well the study drugs work for treating extramedullary disease that has gotten worse after treatment. Extramedullary disease is tumor growth outside of the bone or bone marrow.
Study Topics
Finding Ways to Improve Health for Older Adults with B-cell Non-Hodgkin Lymphoma or Multiple Myeloma
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
Study Topics
Treating Newly Diagnosed Higher-Risk Myelodysplastic Syndrome with Tamibarotene
The purpose of this study is to see how well the study drug, Tamibarotene, works for treating higher-risk myelodysplastic syndrome. The study drug will be given along with a drug called Vidaza. We want to know if this approach is better than the usual approach.
Study Topics
Study of Canakinumab for Treating Myelofibrosis
The purpose of this study is to find out how well Canakinumab works for treating myelofibrosis.
Study Topics
Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
Study Topics
A Study of the Drug ABBV-383 for Patients with Multiple Myeloma
The purpose of this study is to learn more about the study drug ABBV-383 for patients with multiple myeloma that has returned or has not responded to treatment. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
Testing a New Treatment for Myeloproliferative Disorders
The purpose of this study is to see how well the study drug, INCA033989, works for treating myeloproliferative disorders. We want to find what effects, if any, this therapy may have on people. We also want to find out what is the highest dose that can be given without causing severe side effects.
Study Topics
Learning More About Treating Multiple Myeloma with Lower Doses of Isa-Pom-Dex
The purpose of this study is to find out how well the study drugs isatuximab, pomalidomide and dexamethasone (Isa-Pom-Dex) work when given at lower doses. Using Isa-Pom-Dex at lower doses may help patients get a better response from treatment. The lower doses may also cause fewer or less severe side effects.
Study Topics
Testing the Addition of a New Drug, Daratumumab/rHuPH20, to the Usual Treatment for Multiple Myeloma
The purpose of this study is to see how well adding the drug, daratumumab/rHuPH20, to the usual treatment works for treating multiple myeloma. We want to find out if adding the drug could help patients live longer after stem cell transplant.
Study Topics