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Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
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Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
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Finding the Best Blood Cancer Treatment Using Blood Tests
The purpose of this study is to find out if doctors can quickly test blood and bone marrow to look for signs that help choose the best cancer treatment. These signs, called markers, can show which treatments might work best. If your test shows certain markers, you might be able to join a special treatment group. If not, your doctor will give you the usual care. We are looking for volunteers who have previously untreated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
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Studying Cirtuvivint for Blood Cancer
The purpose of this study is to learn more about a medicine called cirtuvivint for certain blood cancers. Our researchers will study this medicine by itself or together with another pill called ASTX727. We want to learn how safe these medicines are, find the best dose, and see how they affect the cancer. This study is for volunteers with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML).
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Study of the Drug Inotuzumab Ozogamicin in Patients with Disseminated B-cell Lymphoblastic Lymphoma
The purpose of this study is to learn more about the health of caregivers. We want to understand how life experiences before and during caregiving for someone with dementia may impact physical and emotional health over time. The goal is to find better ways to help caregivers feel supported. This study is done completely over the phone. Volunteers will get one call for an interview and then a follow-up call to connect them to resources, if needed.
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Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
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Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
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Studying New Treatments for Children and Young Adults With Relapsed B-ALL
The purpose of this study is to look at a new way to treat a blood cancer called B-ALL that has come back after prior treatment. Researchers will see if the medicine combination of blinatumomab and nivolumab is more effective than blinatumomab alone. The goal is to find safer treatments that help people stay healthy longer.
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Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
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Studying a New Medicine for a Rare Blood Cancer - Chronic Myeloid Leukemia (CML)
The purpose of this study is to learn more about a medicine for a rare blood cancer called chronic myeloid leukemia. We want to see if the medicine TERN-701 can safely stop or slow down cancer. This study is for patients with chronic myeloid leukemia (CML) who have already tried other treatments that did not work or caused problems.
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Comparing Two Medicines for CLL and SLL Blood Cancer
The purpose of this study is to see how two different medicines work for people with a type of blood cancer called CLL or SLL. We will compare how safe the medicines are and how well they help control the cancer. Our researchers hope to find out which medicine works better for people whose cancer has already been treated.
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Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Graft-versus-host disease happens when the new cells from a stem cell transplant attack the patient's own body cells. This study aims to learn more about a new medicine called ruxolitinib to prevent this disease after a stem cell transplant. We will compare this medicine to the standard treatment. Volunteers must be planning to undergo a stem cell transplant for leukemia or lymphoma. The study team will provide more information.
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A Study of the Drug AZD5492 for Blood Cancer
The purpose of this study to learn more about the study drug AZD5492. We want to see if this study drug is safe and helpful for treating blood cancers that have not gotten better with other treatments. We need volunteers with certain types of blood cancer like B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma. The study team will provide more information.
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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Study of Iadademstat Added to Standard Blood Cancer Treatment
The purpose of this study is to learn if adding a new medicine called iadademstat to a standard treatment may work better for a serious type of blood cancer. Researchers will compare treatment with one medicine alone to treatment with both medicines together. They will look at how well the cancer responds and how safe the treatments are. This study is for volunteers with a type of blood cancer called Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) that is getting worse and may turn into acute leukemia.
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Studying Money Stress Among Patients with Leukemia
The purpose of this study is to see if helping people with money problems during cancer treatment can make them feel better and stay healthier. People in the study will answer questions about their health, feelings, and money. The goal is to find out if special help with money makes a difference.
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Predicting AML Relapse with Blood Tests
Some patients with Acute Myeloid Leukemia who get a stem cell transplant might not get better. This study aims to create blood tests to predict which patients will relapse early. These tests check how certain white blood cells (T cells) work. If successful, these tests could help doctors decide the best treatment for patients.
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Studying the Medicine BLEXIMENIB for Patients with Acute Myeloid Leukemia
The purpose of this study is to learn more about a new medicine called BLEXIMENIB. We want to see if it works better when added to two other medicines for people with a kind of blood cancer called acute myeloid leukemia (AML). This study is for people with changes in the KMT2A or NPM1 gene, who are not able to get stronger chemotherapy.
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Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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