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Studying the Use of Triapine with Radiation Therapy for Brain Cancer
The purpose of this study is to learn more about a medicine called triapine for people with a type of brain cancer called glioblastoma or astrocytoma that has come back. We want to see if this medicine is safe to take with radiation therapy and how well the two treatments work together to slow down the tumor. We will also study how the body handles the medicine.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers Cancer: Solid Tumor
Studying the Medicine KQB54 for Previously Treated Pancreas, Colon, or Non-Small Cell Lung Cancer that Has Spread
The purpose of this study is to learn more about a medicine called KQB548. Our researchers want to see if the medicine can safely help people with an advanced solid tumor that has a KRAS G12D mutation. They also want to learn if the medicine is safe and find the best dose to use, while also seeing how it affects cancer growth.
Study Topics
Studying NDI-219216 for Advanced Solid Tumors with MMR deficiency
The purpose of this study is to learn more about a new medicine for advanced solid tumors. Our researchers will see if the medicine is safe and how the body handles it. The study will also look at whether the pill can help slow down or shrink certain advanced cancers.
Study Topics
Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
Study Topics
Cancer Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin Cancer: Solid Tumor
Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
Study Topics
Testing Treatment Before Surgery for Advanced Head and Neck Cancer
This study is testing whether giving chemotherapy or chemo-immunotherapy before surgery works better than surgery alone for advanced head and neck cancer. Researchers want to learn if this approach can help more people stay cancer-free after treatment.
Study Topics
Studying the Drug SGR3515 for Patients with Advanced Solid Tumors
The study aims to learn about the drug SGR-3515. We want to see if it is safe and works well for treating advanced solid tumors. We also want to find the best dose and schedule for treating your cancer. We are looking for volunteers with advanced solid tumors who have either stopped benefiting from or cannot tolerate previous treatments, or whose cancer has returned.
Study Topics
Studying a New Treatment to Help Stop High‑Risk Bladder Tumors
The purpose of this study is to learn more about a new treatment for people with bladder cancer that has not spread into the muscle but could become more serious over time. This is called high-risk, non-muscle invasive bladder cancer (NMIBC). Our researchers want to see if a treatment called cretostimogene grenadenorepvec can safely kill cancer cells, stop the tumor from coming back, and for how long it can help.
Study Topics
A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
Study Topics
Comparing Hearing Loss in Cancer Patients
The main goal of this study is to find out if there is a difference in hearing loss between cancer patients who get the treatment cisplatin and those who get the treatment carboplatin. We want to know how hearing loss affects patients in their daily lives. To find out, we will make a questionnaire that asks about your own experiences with hearing loss or hearing problems. We are looking for volunteers with germ cell tumors who have been treated with either cisplatin or carboplatin.
Study Topics
Cancer Cancer: Children, Teens Cancer: Rare Cancers Cancer: Solid Tumor
Comparing Chemotherapy Schedules for Germ Cell Tumors
The purpose of this study is to find out if giving chemotherapy drugs on a faster schedule helps patients with advanced germ cell tumors. We will compare the regular 3-week cycle with a faster paced 2-week cycle. We want to see if the faster schedule is useful and safe for the patients.
Study Topics