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Improving the Care and Health of Children, Adolescents, and Young Adults with Inflammatory Bowel Disease
The purpose of this study is to improve the care and health for children, teens, and young adults with IBD (Inflammatory Bowel Disease). We want to gather information from your regular care visits to help improve the care for patients with inflammatory bowel disease. For example, we could learn which type of medication works best for treating this disease.
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Finding Signs of Hearing Problems in Babies with Cytomegalovirus Infection Present at Birth
The purpose of this study is to learn more about tests that can be used to show how a baby's hearing will be affected if they have cytomegalovirus (CMV) infection present at birth.
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Infectious Diseases Screening and Prevention Children, Infants, Teen Health Ears, Nose, Throat, Mouth
Studying the Medicine COM701 to Help Keep Ovarian Cancer Away
The purpose of this study is to learn more about a study medicine called COM701. Our researchers want to find out if this medicine is safe and works as a maintenance treatment for people whose ovarian cancer has come back after finishing chemotherapy.
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Studying a New Medicine for a Kidney Disease Called FSGS
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that slowly gets worse over time. It damages the tiny filters in the kidneys, causing scars and making the filters leaky. This lets protein leak into the urine. The purpose of this study is to learn more about a new medicine for this disease. Our researchers want to see if it can lower the amount of protein in the urine and help slow kidney damage when taken with a common blood pressure medicine called an ARB.
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Studying a New Medicine for Kids and Teens with Generalized Myasthenia Gravis
Generalized myasthenia gravis is a disease that makes muscles weak because the body's defense system attacks the spot where nerves and muscles connect. The purpose of this study is to learn more about a new medicine for kids and teens with this disease. Our researchers want to find out if the medicine is safe, how it works inside the body, and if it helps kids feel better and do everyday things more easily.
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Rare Disease Brain and Memory Children, Infants, Teen Health
Can Regular Phone Calls with a Care Manager Improve Quality of Life for People with Post-Traumatic Epilepsy
The purpose of this study is to find out if regular phone calls from a care manager can help patients with post-traumatic epilepsy and symptoms of anxiety and/or depression. The care manager will talk about anxiety, depression, seizures and side effects. They will also provide you with brief therapy sessions. We want to know if this approach helps improve emotional quality of life.
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Studying Causes of Heart Failure
This purpose of this study is to understand what causes heart failure. Some people with early-stage heart failure might not know they have it because they feel fine, while others may have many or few symptoms. We want to learn why some people get heart failure and how to better classify it for targeted treatments. We are recruiting volunteers with and without heart failure to learn more.
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Studying the Drug Metformin for Older Patients with Heart Failure
This study wants to see if the medicine Metformin XR can help older people with this heart problem. We also want to learn about the side effects and see if it can make their health better.
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New Treatment for ANCA Vasculitis in Kids and Teens
Active ANCA-associated Vasculitis is a disease where the body's immune system accidentally attacks its own small to medium-sized blood vessels. This makes the blood vessels swollen and damaged. The purpose of this study is to learn more about a treatment to help kids and teens with this disease. We want to see if the treatment called avacopan is safe and helpful.
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Rare Disease Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Studying a New Medicine for Crohn's Disease
The purpose of this study is to learn more about a new medicine for people with Crohn's disease who have not gotten better with other treatments. Volunteers in the study will get either the new medicine or a look-alike with no medicine in it. Our researchers will check if the new medicine works and is safe.
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A Study of the Drug ORIC-944 for Patients with Prostate Cancer
The purpose of this study is to learn more about the study drug ORIC-944. We want to see if this study drug is safe and useful to treat patients with prostate cancer that has spread to other areas of the body.
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Studying New Treatments for High-Risk Head and Neck Cancer
The purpose of this study is to find a new treatment for people with head and neck cancer. We want to see if using radiation therapy with two different mixes of drugs is better than the usual treatment. The first mix is radiation therapy with the drugs called docetaxel and cetuximab. The second mix is radiation therapy with the drug called cisplatin and an immunotherapy drug called atezolizumab. We are looking for volunteers who have had surgery to remove high-risk cancer in the mouth, throat, voice box, or lower throat.
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Comparing Treatments for Patients with Newly Diagnosed AML
The purpose of this study is to see how well the study drug, CPX-351 works for treating acute myeloid leukemia. We want to find out if this approach works better than the usual approach. We also want to learn more about the possible side effects of this treatment.
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Studying Cystic Fibrosis Treatments for People without Modulators
The purpose of this study is to collect health information and samples from people who have cystic fibrosis (CF). By doing this, researchers can learn more about CF and find new ways to treat it. We also want to help people with CF understand what it's like to be part of a research study. We are looking for volunteers who have CF and do not take a certain type of medicine called CFTR modulators.
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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
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Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
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Studying Chemo Before Surgery for Abdominal Sarcoma
The purpose of this study is to learn more about giving chemotherapy before surgery for a type of cancer called retroperitoneal sarcoma. We want to see if this helps lower the chance of the cancer coming back. We will compare two groups: one that gets surgery only and one that gets chemotherapy first and then surgery. This will help doctors learn which treatment works better in the future.
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Share Your Journey with DUPIXENT® to Help Others
Eosinophilic esophagitis (EoE) is a condition where certain white blood cells build up in the esophagus, making it harder to swallow. The purpose of this study is to learn how people with this health problem use a medicine called Dupixent®, also known as dupilumab, as part of their regular care. Our researchers will collect information from regular doctor visits, short online surveys, and occasional check-ins-all done online to make it easy. Volunteers in this study will not get any extra tests or treatments, and their usual care will not change. By sharing your experience, you can help us understand how Dupixent® works in everyday life.
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Studying a New Medicine for Muscle Weakness Diseases
The purpose of this study is to see if a new medicine called anifrolumab helps people with muscle weakness diseases called polymyositis and dermatomyositis. The medicine will be given as a shot under the skin, along with regular treatment. The study will check if this medicine helps people feel better and need less of their usual medicine.
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Movement Disorder Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Dental Cleaning and Gum Health Research Study
The purpose of this study is to learn how professional teeth cleaning and daily tooth care may affect the bacteria that can enter the bloodstream during brushing. Volunteers will receive a professional dental cleaning, learn more about the health of their teeth and gums, and help researchers better understand how good oral care may support overall health. We are looking for volunteers who have not had their teeth professionally cleaned in 12 months or longer, do not need an antibiotic before a dentist visit, and have at least 10 teeth.
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