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Studying Two Ways to Treat Stomach Cancer
The purpose of this study is to learn more about different ways to treat stomach cancer. Our researchers want to see if giving a cancer medicine called paclitaxel directly into the belly, along with regular chemotherapy, can help lower the chance of stomach cancer growing or spreading. We will compare this new treatment to the usual care most people get for stomach cancer.
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Studying CAR T-Cell Therapy for Aggressive B-Cell Lymphoma
The purpose of this research is to find new ways to treat lymphomas that have come back or stopped responding to treatment. Researchers will study a new cell therapy made from a person's own immune cells for aggressive B‑cell lymphoma. The study looks at how safe this treatment is and how well it helps shrink or control the cancer.
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Studying a Lower Dose of Tamoxifen for Breast Cancer
The purpose of this study is to see if a lower dose of tamoxifen works as well as the regular dose to treat early-stage breast cancer. Tamoxifen is a medicine that helps stop cancer from coming back. Our researchers will also look at whether the lower dose causes fewer side effects for patients.
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Using a Small Device to Track Muscle Changes in ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly makes muscles weaker and harder to control, making it tough to walk, talk, or breathe. The purpose of this study is to see how a small device called the mScan can measure muscle changes in people with ALS. The device uses a tiny, painless electrical signal to check muscles. Our researchers hope this will help track ALS over time and see how well treatments work.
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Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Studying a New Medicine for Severe Heart Failure
The purpose of this study is to find out if a new medicine called omecamtiv mecarbil can help people with serious heart failure. The medicine may help the heart pump better and lower the chance of problems like hospital visits or other serious health issues. We hope this research will help doctors treat heart failure in the future.
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Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
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Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
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Studying the Medicine Remibrutinib for a Chronic Skin Condition
Hidradenitis suppurativa is a skin disease that causes painful lumps under the skin, often in areas like the armpits or groin. The purpose of this study is to see if the medicine remibrutinib can help adults with this disease. We want to see if the medicine can safely improve symptoms and improve overall health and well-being.
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Studying the Medicine CREXONT for Parkinson's Disease
The purpose of this study is to learn more about the medicine CREXONT. We want to see if this medicine is safe and useful for patients with Parkinson's disease in their daily lives.
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Studying Care Choices After Breast Cancer Surgery
The purpose of this study is to compare two different approaches to care for breast cancer after surgery. Our researchers want to find out whether closely monitoring patients after surgery works just as well as giving additional medication to prevent the cancer from returning. This study is for volunteers who had triple-negative breast cancer and showed no signs of cancer after completing chemotherapy and surgery. The results will help doctors determine the best way to care for patients in this situation.
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Studying a Rare Blood Condition Over Time
The purpose of this study is to learn more about a rare blood problem called plasminogen deficiency. Researchers will collect blood, urine, and health information to find out who gets symptoms and how to help them. The goal is to improve care for people with this condition.
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A Study of a Vaccine to Help Prevent C. diff
Clostridioides difficile (C. diff) is a germ that can spread from person to person. It can cause very bad diarrhea and, in serious cases, can be life threatening. This study looks at whether a new vaccine can help prevent C. diff diarrhea or make the illness less severe, reduce doctor visits, or lower the need for antibiotics in adults age 65 and older.
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Studying the Supplement Fisetin to Help Cancer Survivors with Tiredness
The purpose of this study is to learn more about fisetin, a dietary supplement. We want to find out if this supplement can help reduce tiredness in people who have had cancer treatments. We will compare this supplement to a placebo. We are looking for volunteers who previously had cancer treatments that often cause tiredness. The study team will provide more information.
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Studying New Drug Combinations for Advanced Small Cell Lung Cancer
The purpose of this study is to find the highest safe dose of a new drug, iadademstat, when used with other cancer drugs (atezolizumab or durvalumab) in people with advanced small cell lung cancer. The study will check for side effects and see how well the drug combination works. This may help doctors learn if this new treatment is better or worse than the usual care for this cancer.
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Finding the Best Blood Cancer Treatment Using Blood Tests
The purpose of this study is to find out if doctors can quickly test blood and bone marrow to look for signs that help choose the best cancer treatment. These signs, called markers, can show which treatments might work best. If your test shows certain markers, you might be able to join a special treatment group. If not, your doctor will give you the usual care. We are looking for volunteers who have previously untreated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
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Helping the Brain Relax to Improve Sleep and Stress
The purpose of this study is to learn more about a new technology called Cereset Research (CR). It uses sounds linked to your brainwaves to help your brain relax and balance. In this study, you will continue your other current care, but will also receive sessions of CR. The goal is to see if it helps people with stress, anxiety, or trouble sleeping. We are looking for volunteers with symptoms following a concussion or traumatic brain injury (TBI), ongoing symptoms of long-COVID, or a functional movement disorder.
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Adding Chemotherapy to Hormone Treatment for Advanced Prostate Cancer
The purpose of this study is to see if adding a chemotherapy drug called docetaxel to standard hormone treatment can slow down advanced prostate cancer. Researchers want to learn if this combination works better than hormone treatment alone. The results may help improve care for people with prostate cancer in the future.
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Studying Access to Food and its Impact on Blood Pressure
The purpose of this study is to learn more about access to food and blood pressure. Our researchers would like to explore different ways of helping people get better access to food and see if it can help improve their blood pressure. Some people will get help from a community health worker, and others may get meals made for people with high blood pressure. The goal is to find out which way works best. We are looking for volunteers who have high blood pressure and experience a lack of regular access to food.
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Opinions, Social Issues Weight, Metabolism, Nutrition Wellness and Lifestyle Blood Pressure
Studying a New Treatment Combination for Nasopharyngeal Cancer
The purpose of this study is to learn more about combining a medicine called nivolumab to chemotherapy for people with newly diagnosed nasopharyngeal cancer. Our researchers also want to see if some children can safely receive less radiation based on how well the cancer responds. The goal is to treat the cancer while lowering side effects.
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Studying the Medicine Triptorelin to Protect Ovaries During Chemotherapy
The purpose of this study is to learn more about a medicine called triptorelin. We want to find out if it can help protect the ovaries of teens and young adults during cancer treatment. Some cancer drugs can damage the ovaries and make it harder to have children later in life. Our researchers are studying this medicine to see if it works better than the usual methods used to protect the ovaries. We are looking for women volunteers with cancer who are receiving a specific type of chemotherapy called an alkylating agent.
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