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A Study of the Drug ORIC-944 for Patients with Prostate Cancer
The purpose of this study is to learn more about the study drug ORIC-944. We want to see if this study drug is safe and useful to treat patients with prostate cancer that has spread to other areas of the body.
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Understanding Slow Stomach Emptying
Gastroparesis is a disease where the stomach does not empty food the way it should. People with diabetes, people who had stomach surgery, or people who had certain viruses may be more likely to get it. This study wants to learn what causes this problem and how to stop it or create better treatments by comparing people who have it with people who do not. We are looking for volunteers who have been diagnosed with gastroparesis or functional dyspepsia and are scheduled for a surgical procedure on their abdomen. During this procedure a biopsy will be taken of the stomach and used for research purposes.
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Studying New Treatments for High-Risk Head and Neck Cancer
The purpose of this study is to find a new treatment for people with head and neck cancer. We want to see if using radiation therapy with two different mixes of drugs is better than the usual treatment. The first mix is radiation therapy with the drugs called docetaxel and cetuximab. The second mix is radiation therapy with the drug called cisplatin and an immunotherapy drug called atezolizumab. We are looking for volunteers who have had surgery to remove high-risk cancer in the mouth, throat, voice box, or lower throat.
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Comparing Treatments for Patients with Newly Diagnosed AML
The purpose of this study is to see how well the study drug, CPX-351 works for treating acute myeloid leukemia. We want to find out if this approach works better than the usual approach. We also want to learn more about the possible side effects of this treatment.
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Studying Cystic Fibrosis Treatments for People without Modulators
The purpose of this study is to collect health information and samples from people who have cystic fibrosis (CF). By doing this, researchers can learn more about CF and find new ways to treat it. We also want to help people with CF understand what it's like to be part of a research study. We are looking for volunteers who have CF and do not take a certain type of medicine called CFTR modulators.
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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
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Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
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Studying Chemo Before Surgery for Abdominal Sarcoma
The purpose of this study is to learn more about giving chemotherapy before surgery for a type of cancer called retroperitoneal sarcoma. We want to see if this helps lower the chance of the cancer coming back. We will compare two groups: one that gets surgery only and one that gets chemotherapy first and then surgery. This will help doctors learn which treatment works better in the future.
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Share Your Journey with DUPIXENT® to Help Others
Eosinophilic esophagitis (EoE) is a condition where certain white blood cells build up in the esophagus, making it harder to swallow. The purpose of this study is to learn how people with this health problem use a medicine called Dupixent®, also known as dupilumab, as part of their regular care. Our researchers will collect information from regular doctor visits, short online surveys, and occasional check-ins-all done online to make it easy. Volunteers in this study will not get any extra tests or treatments, and their usual care will not change. By sharing your experience, you can help us understand how Dupixent® works in everyday life.
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Studying a New Medicine for Muscle Weakness Diseases
The purpose of this study is to see if a new medicine called anifrolumab helps people with muscle weakness diseases called polymyositis and dermatomyositis. The medicine will be given as a shot under the skin, along with regular treatment. The study will check if this medicine helps people feel better and need less of their usual medicine.
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Movement Disorder Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Dental Cleaning and Gum Health Research Study
The purpose of this study is to learn how professional teeth cleaning and daily tooth care may affect the bacteria that can enter the bloodstream during brushing. Volunteers will receive a professional dental cleaning, learn more about the health of their teeth and gums, and help researchers better understand how good oral care may support overall health. We are looking for volunteers who have not had their teeth professionally cleaned in 12 months or longer, do not need an antibiotic before a dentist visit, and have at least 10 teeth.
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Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
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Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
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Heart Device Safety and Medication Study
The purpose of this study is to learn more about a device to help patients with a heart condition called atrial fibrillation. We want to see how safe and useful different medications are after the device called WATCHMAN FLX Pro is placed in the heart. This device helps prevent blood clots and strokes in patients with atrial fibrillation.
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Comparing Two Medicines for Adults With Ulcerative Colitis
The purpose of this study is to see which of two medicines helps adults with ulcerative colitis feel better. Ulcerative colitis is a disease that causes swelling and sores in the large intestine, which can lead to stomach pain and diarrhea. People in the study will get one of the medicines, and doctors will see which one works best to treat their symptoms.
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Studying a New Medicine for Juvenile Psoriatic Arthritis
Juvenile psoriatic arthritis is a disease in kids and teens that causes joint pain and swelling along with skin problems like red, scaly patches. The purpose of this study is to learn more about the medicine secukinumab for this disease. We will check if the medicine is safe and how the body handles it.
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Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Helping Women Lower Their Risk for HIV
The purpose of this study is to learn more about a program called SHE CARES, which is created to help women reduce their risk of getting HIV. This program is for women who have used stimulants such as methamphetamine (meth) or cocaine by injection in the last 6 months. The goal is to create a supportive program that helps women stay healthy.
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Screening and Prevention Substance Use (Alcohol, Illegal Drugs, Tobacco) Women's Health
Studying a New Medicine for Advanced Bladder Cancer
The purpose of this study is to learn more about the medicine called Disitamab Vedotin. We want to see if this medicine helps people with advanced bladder cancer that has a certain protein called HER2. We will check if the medicine can shrink or slow down the cancer and if it is safe for patients. Doctors will also look at how the treatment affects how people feel and their quality of life.
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Studying Genes and Weight Loss in Patients with Pancreatic Cancer
The purpose of this study is to understand how genes are related to weight loss in people with pancreatic cancer. Weight loss is a common issue for those with pancreatic cancer and can make life more difficult and treatments less useful. We hope to learn how to better treat and help future patients. We are seeking volunteers who have pancreatic cancer that has spread and cannot be removed by surgery.
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