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Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
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Testing the Study Drug RGX-314 for Patients with Vision Loss
The purpose of this study is to learn more about the drug RGX-314. We want to see if this drug helps people with an eye disease called neovascular age-related macular degeneration. We also want to see if this drug can make their vision better or keep it from getting worse.
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How Damage to Blood Vessels in the Brain May Be Related to Thinking and Memory Problems Like Dementia
This study is being done to better understand how damaged blood vessels affect your thinking. This is not a treatment study.
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Understanding How the Brain Combines Vision and Hearing to Perform Everyday Tasks
The purpose of this research study is to learn more about how the brain combines vision and hearing to perform everyday tasks, like listening to a conversation when there is background noise, for people experiencing changes in memory and/or have a diagnosis of memory loss. Participants will need to attend the visit with a study partner, like a friend or family member.
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Learning More About How HIV and Marijuana Affect the Brain
The purpose of this study is to learn more about how HIV and marijuana affect the brain. This will help us understand how changes in the brain affect the way we think and behave.
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Healthy Volunteers HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco)
Studying New Vaccine for Stomach Flu
The purpose of this study is to learn more about a new vaccine called mRNA-1403. We want to see if the vaccine is safe and works well to prevent stomach flu caused by norovirus.
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Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
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Virtual Reality Rehabilitation Method for Treating a Type of Vision Loss Called Visual Hemianopia
The purpose of this study is to see how well a new rehabilitation method works for treating visual hemianopia. Visual hemianopia is loss of half the vision in the right or left side of each eye. This rehabilitation may help restore vision.
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Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
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Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
The Use of Muscle Fiber Fragments to Treat the Loss of Bladder Control in Women
The purpose of this study is to find out if injecting muscle fiber fragments into the bladder can treat bladder leakage in women. Taking part in this study will include seven study visits in a year.
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Studying a New Cream for Hidradenitis Suppurativa
The goal of this study is to find out more about a new treatment for people with head and neck cancer. We want to see if using a treatment called Petosemtamab along with another treatment called pembrolizumab can help stop the cancer from growing or spreading and make patients feel better. We are looking for volunteers who have head and neck cancer that has spread to other parts of their body or has not gotten better with other treatments. The study team will give more details.
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Studying New Treatments for Head and Neck Cancer Patients
The goal of this study is to find out more about a new treatment for people with head and neck cancer. We want to see if using a treatment called Petosemtamab along with another treatment called pembrolizumab can help stop the cancer from growing or spreading and make patients feel better. We are looking for volunteers who have head and neck cancer that has spread to other parts of their body or has not gotten better with other treatments. The study team will give more details.
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Reducing Infection Risk in C-Section Deliveries
The goal of this study is to find a way to lower the chance of getting an infection after a C-section. We want to see if using two antibiotics instead of one before the C-section can help prevent infections like endometritis, wound infection, or sepsis. We are looking for volunteers who are at least 23 weeks pregnant and are planning to have a C-section.
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Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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Studying a New Medicine for Polycythemia Vera
Polycythemia vera is a blood disease where the body makes too many red blood cells. The purpose of this study is to learn more about a new medicine called DISC 3405 for this disease. Our researchers will look at how the medicine works in the body and what dose works best.
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Understanding Fertility Choices for People with Spinal Cord Injuries
The purpose of this study is to learn how well people with spinal cord injuries understand their options for having children and how to improve that understanding. Volunteers in the study will complete an anonymous online survey, and results will be used to compare views and choices about fertility. After finishing, volunteers will be given resources with fertility information and options.
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Studying the Medicine Erdafitinib for Brain Cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
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Studying a New Medicine for Heart and Lung Health
Pulmonary hypertension with heart failure with preserved ejection fraction (PH‑HFpEF) is a type of heart problem where the heart does not relax and fill with blood the way it should. This causes higher pressure in the blood vessels that go to the lungs, which can make breathing harder. The purpose of this study is to learn more about a new medicine called levosimendan by comparing it to a placebo, which is a pill with no medicine.
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Comparing Two Treatments for Myasthenia Gravis
Myasthenia gravis (MG) is a rare disease that makes it hard for nerves and muscles to work together. The goal of this study is to compare two medicines, nipocalimab and efgartigimod, to see how well they work and how safe they are for people with this disease. The study will also look at how safe and helpful nipocalimab is for people who switch from efgartigimod.
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Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
The Osteoarthritis Prevention Study (TOPS)
Exercise and diet have been shown to help with the treatment of osteoarthritis. The purpose of this study is to find out if exercise and diet prevents osteoarthritis.
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Arthritis, Lupus, and Autoimmune Disorders Weight, Metabolism, Nutrition