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Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
Study Topics
Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Blood Test to Guide Chemotherapy After Colon Cancer Surgery
This study wants to see if a blood test can help doctors decide which chemotherapy is best after colon cancer surgery. The blood test looks for cancer DNA in the blood. The goal is to find out if this new way is better, the same, or worse than the usual treatment.
Study Topics
Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
Study Topics
Treating Prostate Cancer with AMG 509
The purpose of this study is to see how well the study drug, AMG 509, treats prostate cancer. We also want to learn about any side effects caused by the study drug.
Study Topics
Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
Study Topics
Learning More About Treating Childhood Absence Epilepsy and Juvenile Absence Epilepsy with Brivaracetam
The purpose of this study is to see how well the study drug, brivaracetam, treats childhood absence epilepsy or juvenile absence epilepsy. We also want to learn more about any possible side effects it may cause.
Study Topics
Learning More About Preventing Bone Loss in Older Adults that Have Lost Weight
The purpose of this study is to see if losing weight affects bone health in older adults. You will join a group to help you lose weight and may do exercises at a gym three times a week. You might also take a pill called alendronate, which helps keep bones strong, or a placebo for one year.
Study Topics
Finding Therapies that Improve Survival for Patients with Glioblastomas
The purpose of this research is to test multiple study treatments for glioblastoma. We want to find out if any of these study treatments can improve how long patients live.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
Study Topics
High Blood Pressure in Children and Teenagers
The purpose of this study is to understand what causes high blood pressure in young people. We also want to learn more about how high blood pressure can cause damage to the heart and kidneys.
Study Topics
Healthy Volunteers Heart Health Children, Infants, Teen Health
Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
Study Topics
Can Immunotherapy Help Non-Small Cell Lung Cancer Patients Improve Physical Function
The purpose of this study is to see if treatment with immunotherapy can help lung cancer patients who get tired easily and struggle with some daily tasks.
Study Topics
Is it More Helpful to Give Children with Germ Cell Tumors Chemotherapy on a Faster Schedule
A germ cell tumor is a type of cancer found in the ovaries for females or the testes for males. This tumor may also be found in the pelvis along the tailbone, chest, abdomen, and other structures of the body. Chemotherapy is the medicine used to fight cancer. We want to find out if giving children with germ cell tumors chemotherapy on a faster schedule is effective.
Study Topics
Targeted Drug Treatment for Patients with Growing Brain Tumors
The purpose of this study is to see if certain drugs work better for people with meningiomas (a type of brain tumor) that have specific gene changes. The goal is to see if using genetic testing can help pick the best treatment. Researchers hope this will help shrink tumors and improve care for future patients.
Study Topics
How the Brain Processes Information
The purpose of this study is to look at how the human brain processes information. We want to know how the human brain responds to different stimuli, how those stimuli make you feel, and how your feelings guide your decisions.
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Combination Chemotherapy for Newly Diagnosed and Relapsed Wilms Tumor
The purpose of this study is to find out if we can improve treatment for those with Wilms tumors. We will be testing three different combinations of radiation and chemotherapy. The combination you receive will depend on your type of Wilms tumor.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Children, Infants, Teen Health
I-SPY 2 TRIAL: Study of New Drugs to Treat Breast Cancer Before Surgery
The purpose of this study is to learn more about giving the best treatment at the right time. Treatment on this study will be given before surgery. This allows us to better understand how different people's breast cancers respond to commonly used chemotherapy with or without new drugs.
Study Topics
A Study of the Drug Fluticasone Propionate and Albuterol Sulfate to Treat Asthma
The purpose of this study is to learn more about the study drug Fluticasone Propionate and Albuterol Sulfate. We want to see how well the study drug works for treating symptoms of asthma and preventing severe asthma attacks.
Study Topics
Learning More About Treating Gastric, Gastroesophageal Junction and Pancreatic Tumors with ASP2138
The purpose of this study is to find out how well the study drug, ASP2138, works for treating gastric, gastroesophageal junction or pancreatic tumors. We also want to learn more about the side effects that may be caused by the study drug.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Cancer: Stomach and Intestines