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Testing a New Device for Pelvic Prolapse
The purpose of this study is to test a new device called the Reia System. We want to see if the device is safe and useful for women with pelvic organ prolapse when used at home. We are looking for volunteers who have not used a pessary before.
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Studying a New Medicine for Myelofibrosis
The purpose of this study is to learn more about a new medicine called Canakinumab. We want to see if it helps people with a rare bone marrow cancer called myelofibrosis. The medicine will be used along with another medicine that patients are already taking. The goal is to find out if this new medicine is safe and if it helps people feel better.
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Studying a New Endometrial Cancer Medicine
The goal of this study is to learn about a new cancer medicine called Sacituzumab Govitecan. This medicine is for patients whose endometrial cancer has returned. We want to find out if this medicine can help patients live longer and slow down or stop their cancer from growing. We will compare this medicine to regular chemotherapy treatments like doxorubicin or paclitaxel.
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Brain Changes after Radiation Treatment for Glioma
Glioma is a type of brain cancer. The purpose of this study is to see if we can predict how brain function will change after radiation treatment for glioma. We will be doing PET scans and blood tests with glioma patients. A PET scan is a type of test that gives us images of your brain and can help detect certain diseases.
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The Osteoarthritis Prevention Study (TOPS)
Exercise and diet have been shown to help with the treatment of osteoarthritis. The purpose of this study is to find out if exercise and diet prevents osteoarthritis.
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Arthritis, Lupus, and Autoimmune Disorders Weight, Metabolism, Nutrition
Finding a Way to Predict Success or Failure of Treatment for Atopic Dermatitis and Psoriasis
There are a number of treatments for psoriasis and atopic dermatitis. This has created a need to find a way to figure out which treatment will work best for each patient. The goal of this study is to develop a test that can predict treatment success and/or failure. If you take part in this study, no changes will be made to your treatment for psoriasis or atopic dermatitis.
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Learning More About Treating T-cell Lymphoma with the Study Drug Duvelisib or Azacitidine
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
Study Topics
Learning More About Treating T-cell Lymphoma with the Study Drug Duvelisib or Azacitidine
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
Study Topics
Can Regular Phone Calls with a Care Manager Improve Quality of Life for People with Post-Traumatic Epilepsy
The purpose of this study is to find out if regular phone calls from a care manager can help patients with post-traumatic epilepsy and symptoms of anxiety and/or depression. The care manager will talk about anxiety, depression, seizures and side effects. They will also provide you with brief therapy sessions. We want to know if this approach helps improve emotional quality of life.
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Using Muscle Fiber Fragment Injections to Treat Fecal Incontinence
The purpose of this study is to look at a new way to treat fecal incontinence. We want to know if injecting muscle fiber fragments into the muscle at the bottom of the anus can help with leaking stool.
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Looking at How Estrogen Deprivation Affects Heart Function in Breast Cancer Patients
The purpose of this study is to learn more about how near complete estrogen deprivation therapy effects the heart in breast cancer patients. We want to understand if this therapy changes how the heart works.
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Can Physical Activity Be Helpful for Lymphoma Patients During Treatment?
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Study to See How Well the Study Drug EPX-100 Works for Treating Dravet Syndrome
The purpose of this study is to see how well the study drug, EPX-100, works for treating Dravet syndrome. We also want to learn more about possible side effects.
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Studying New Ways to Reduce Caregiver Stress
The purpose of this study is to see if listening to nature sounds and using a new technology called CR can help people who take care of loved ones feel less stressed. Taking care of someone can be stressful and affect your health. This study will test if CR can help reduce stress symptoms like anxiety, trouble sleeping, and changes in heart rate in a small group of people.
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Healthy Volunteers Mental Health Neurology Disorders Sleep Brain and Memory
Learning More About Treating Systemic Lupus Erythematosus with Litifilimab
The purpose of this study is to find out if the study drug, Litifilimab, can improve symptoms of lupus. We want to see if the study drug can reduce disease activity and inflammation
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Learning More About Treating Low-Grade Glioma with Vinblastine and Selumetinib
The purpose of this study is to learn more about treating low-grade gliomas. We want to find the highest dose of Vinblastine that can be given safely along with Selumetinib. We also want to find out if Selumetinib and Vinblastine combined work better than Selumetinib alone. Studies like this can help improve treatment and quality of life.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Study of Second Look Laparoscopy with Hyperthermic intraperitoneal chemotherapy (HIPEC) in Patients with Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
After their first surgery, patients often have a procedure called second look reassessment surgery. This surgery allows doctors to look inside your body and check for signs of cancer. The purpose of this study is to see how well it works to give HIPEC during the second look surgery. HIPEC is a type of chemotherapy inserted directly into your abdomen at the time of surgery. We want to monitor any effects that this has on your health.
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Women's Health Cancer Cancer: Rare Cancers Cancer: Women's Cancer
Quitting Smoking and Managing Daily Challenges
The purpose of this study is to learn more about the mood, behavior and brains of people who smoke. We want to look at how daily hassles might affect how emotional distress is managed during an attempt to stop smoking. This study does not offer a treatment to stop smoking.
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Healthy Volunteers Substance Use (Alcohol, Illegal Drugs, Tobacco)
Treating Prostate Cancer with Omeprazole and Chemotherapy
The purpose of this study is to find out how Omeprazole may help treat prostate cancer. It will be given along with chemotherapy. Researchers believe Omeprazole may help the chemotherapy work.
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Study of Batoclimab for Treating Active Thyroid Eye Disease
The purpose of this study is to see if batoclimab helps people with active moderate-to-severe thyroid eye disease. We also want to find out if batoclimab is safe.
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