Search Studies
Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
Study Topics
Testing a Radiation-Based Treatment for Prostate Cancer that has Spread
The purpose of this study is to find out if radiation treatment with Lutetium Lu 177 Dotatate can shrink or slow the growth of prostate cancer. We want to find out if this approach is better or worse than the usual approach.
Study Topics
Learning More About Blood Tests to Determine if a Cancer Patient Will Respond to Treatment
Not all patients treated with immune checkpoint inhibitors respond with tumor shrinkage. Many patients have serious side effects. The purpose of this study is to develop blood tests that can help determine if patients will respond to treatment and develop side effects.
Study Topics
Studying Medicines to Help People Breathe Better with COPD
The purpose if this study is to learn more about the medicines Budesonide, Glycopyrronium, and Formoterol Fumarate. We want to see how well the medicines work for preventing chronic obstructive pulmonary disease (COPD) flare-ups.
Study Topics
Treating Uncontrolled Seizures with the Study Drug NRTX-1001
The purpose of this study is to learn more about treating uncontrolled seizures with the study drug NRTX-1001. We want to see how the study drug works and find out what side effects may be caused.
Study Topics
A Study of Telehealth to Treat Children with Medical Complexity
The purpose of this study is to learn more about using telehealth visits for children with medical complexity. We want to find out if telehealth visits can improve the health of children with chronic health problems.
Study Topics
Learning More About How Gut Micro-organisms Play a Role in Prostate Cancer
The purpose of this study is to find out how the gut micro-organisms may affect prostate cancer that spreads to the bone. In this study, the methods required to study these gut-bone interactions will be developed and tested.
Study Topics
Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
Study Topics
A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
Study Topics
Treating Focal Onset Epilepsy with Study Drug BHV-7000
The purpose of this study is to find out how well the study drug, BHV-7000, works for treating focal seizures. We also want to learn more about side effects that may be caused by the study drug.
Study Topics
Understanding How Chemotherapy Treatment Before Surgery Impacts Recovery
The purpose of this study is to learn how chemotherapy treatment before surgery affects your body and brain. Some people get chemotherapy before surgery, and some get it after. By looking at changes in health, doctors hope to understand how chemotherapy before surgery helps people feel better and recover faster. We are looking for volunteers who have recently been diagnosed with a gynecological cancer (ovarian, peritoneal, fallopian tube, or endometrial) and are planning to receive chemotherapy treatment followed by surgery afterwards.
Study Topics
Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
Study Topics
Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
Study Topics
Using Sound Stimulation to Improve Sleep and Depression
The purpose of this study is to test a headband that plays sounds to see if it can help people fall asleep faster. The sounds are designed to change brain activity linked to trouble falling and staying asleep. Researchers also want to see if better sleep may help improve mood. This study is for volunteers who have trouble falling or staying asleep and are experiencing symptoms of depression.
Study Topics
Studying a New Way to Prevent Blood Clots During Medical Procedures
The goal of this study is to help people who need medical procedures where their blood goes outside their body, like during dialysis or heart surgery. We want to find a way to stop blood clots during these procedures. This study will help us learn how to prevent clots and make these procedures safer. We are looking for healthy volunteers, both adults and children, who are 17-70 years old and weigh over 110 pounds.
Study Topics
Studying a New Medicine to Help People with COPD
The goal of this study is to see if a new medicine called lunsekimig can help people with COPD feel better. It will look at how well the medicine works for people who still have breathing problems even though they are already getting treatment. The study will also check if the medicine causes any side effects.
Study Topics
Studying a New Medicine for People with Heart Disease and Obesity
Atherosclerotic cardiovascular disease happens when fatty buildup blocks blood vessels and makes it harder for blood to flow. The purpose of this study is to learn more about a new medicine for people who already have this condition and are overweight or have obesity. The goal is to see if the medicine can help lower their chances of having heart problems in the future.
Study Topics
Using Brain Scans to Track Brain Tumor Changes
The purpose of this study is to learn if special brain scans can give doctors better information about how brain tumors change over time. We will compare regular MRI scans with special MRI scans and, for some people, a PET scan. What we learn may help doctors care for future patients with brain cancer. This study is for volunteers diagnosed with glioblastoma.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying the Medicine VX-670 for Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 is a disease that makes muscles weak and hard to relax, and it can also affect other parts of the body like the heart and stomach. The purpose of this study is to see if a new medicine is safe and works well for people with this disease. Our researchers will see if the medicine can help with muscle problems and check for any side effects over two years.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Learning How the Brain Shifts Attention
The purpose of this study is to learn how people move their attention when they see different things. We will use computer tasks and brain scans to see how your brain works when you pay attention to new things. The goal is to help scientists understand how attention changes in the brain.
Study Topics