Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to learn how your kidneys affect the bones in your feet. We believe that healthy kidneys help keep your foot bones strong. Having diabetes and nerve damage can increase your chances of having kidney and foot problems. You will help us understand more about how they are related which will ultimately help us discover tests and treatments to prevent diabetes related foot problems.
Study Topics
Finding the Best Timing for Surgery and Rehab for a Multiple Ligament Knee Injury
The purpose of this study is to find out if it's best to have surgery shortly after injury or wait. We also want to know if it is best to begin weight bearing and range of motion shortly after surgery or wait a few weeks.
Study Topics
What Causes Bone Pain
The purpose of this research study is to understand what causes bone pain. In this study, methods to study bone pain will be developed and tested.
Study Topics
A Study to Test if Pupil Size Can Be Measured While the Patient is Experiencing Joint Pain From Osteoarthritis
The purpose of this study is to learn more about changes in pupil size when someone is having pain. Changes in pupil size can be a sign of brain activity in a region of the brain that is important for feeling pain. Taking part in this study will include four study visits over about two months. This study may help us learn how to treat pain better.
Study Topics
Learning More About Rheumatoid Arthritis Treatments
The purpose of this study is to learn more about rheumatoid arthritis. We want to learn more about rheumatoid arthritis treatments and how well they work. The information collected in this study may help improve the care of people with rheumatoid arthritis. This is not a treatment study.
Study Topics
Learning More About the Effects of Oxytocin on the Nervous System
Oxytocin is a naturally occurring hormone. The purpose of this study is to see how oxytocin affects the nervous system. We will be looking at how pupils change after an oxytocin injection.
Study Topics
Healthy Volunteers Neurology Disorders Bones, Joints, Muscles
Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
Study Topics
Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
Study Topics
Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles