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Using Ide-Cel to Treat Multiple Myeloma
The purpose of this research is to see if idecabtagene vicleucel (ide-cel) is safe and useful to treat participants with multiple myeloma.
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Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
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Treating Vulvar Dysplasia with a New Surgical Treatment
This study is being done to see if a surgical treatment, Frozen-Section Directed Excision, is better at treating vulvar dysplasia than the usual treatment.
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Using Selinexor to Treat Endometrial Carcinoma
The purpose of this study is to find out if the study drug, selinexor, is safe and effective for treating a type of cancer called endometrial carcinoma.
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Using Selinexor to Treat Endometrial Carcinoma
The purpose of this study is to find out if the study drug, selinexor, is safe and effective for treating a type of cancer called endometrial carcinoma.
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A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
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Studying the Drug JNJ-90014496 for Patients with B Cell Non-Hodgkin Lymphoma
This study aims to learn more about the drug JNJ-90014496. We want to see if this drug is safe and helpful for treating patients with B cell Non-Hodgkin Lymphoma that has come back or hasn't responded to treatment.
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A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
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Testing the Study Drug Bromocriptine for New Moms with Heart Problems
Peripartum cardiomyopathy is when your heart gets weak and big during or after pregnancy. This makes it hard for your heart to pump blood like it should. The study is testing a drug called bromocriptine to help women with this problem.
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Comparing Multi-day Versus Single Day Radiation Therapy for Brain Cancer
This study aims to find out if giving radiation over several days causes fewer side effects than giving it in one day for brain cancer patients on immunotherapy.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Breast Cancer: Kidney, Liver, Pancreas Cancer: Lung Cancer: Skin
Using a Small Device to Track Muscle Changes in ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly makes muscles weaker and harder to control, making it tough to walk, talk, or breathe. The purpose of this study is to see how a small device called the mScan can measure muscle changes in people with ALS. The device uses a tiny, painless electrical signal to check muscles. Our researchers hope this will help track ALS over time and see how well treatments work.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Comparing Two Medicines for Brain Cancer
The purpose of this study is to find out which medicine works better for people who have a type of brain cancer called glioblastoma. We will compare the medicine niraparib and temozolomide, along with radiation therapy. The goal is to see which treatment helps more and is safer.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying a New Medicine for Severe Heart Failure
The purpose of this study is to find out if a new medicine called omecamtiv mecarbil can help people with serious heart failure. The medicine may help the heart pump better and lower the chance of problems like hospital visits or other serious health issues. We hope this research will help doctors treat heart failure in the future.
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Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
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Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
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Studying the Medicine Remibrutinib for a Chronic Skin Condition
Hidradenitis suppurativa is a skin disease that causes painful lumps under the skin, often in areas like the armpits or groin. The purpose of this study is to see if the medicine remibrutinib can help adults with this disease. We want to see if the medicine can safely improve symptoms and improve overall health and well-being.
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Studying the Medicine Bitopertin for Sun Sensitivity
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Studying a Lower Dose of Tamoxifen for Breast Cancer
The purpose of this study is to see if a lower dose of tamoxifen works as well as the regular dose to treat early-stage breast cancer. Tamoxifen is a medicine that helps stop cancer from coming back. Our researchers will also look at whether the lower dose causes fewer side effects for patients.
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Studying the Medicine CREXONT for Parkinson's Disease
The purpose of this study is to learn more about the medicine CREXONT. We want to see if this medicine is safe and useful for patients with Parkinson's disease in their daily lives.
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