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Studying a New Medicine for a Kidney Disease Called FSGS
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that slowly gets worse over time. It damages the tiny filters in the kidneys, causing scars and making the filters leaky. This lets protein leak into the urine. The purpose of this study is to learn more about a new medicine for this disease. Our researchers want to see if it can lower the amount of protein in the urine and help slow kidney damage when taken with a common blood pressure medicine called an ARB.
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Studying a New Medicine for Kids and Teens with Generalized Myasthenia Gravis
Generalized myasthenia gravis is a disease that makes muscles weak because the body's defense system attacks the spot where nerves and muscles connect. The purpose of this study is to learn more about a new medicine for kids and teens with this disease. Our researchers want to find out if the medicine is safe, how it works inside the body, and if it helps kids feel better and do everyday things more easily.
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Can Regular Phone Calls with a Care Manager Improve Quality of Life for People with Post-Traumatic Epilepsy
The purpose of this study is to find out if regular phone calls from a care manager can help patients with post-traumatic epilepsy and symptoms of anxiety and/or depression. The care manager will talk about anxiety, depression, seizures and side effects. They will also provide you with brief therapy sessions. We want to know if this approach helps improve emotional quality of life.
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Studying Causes of Heart Failure
This purpose of this study is to understand what causes heart failure. Some people with early-stage heart failure might not know they have it because they feel fine, while others may have many or few symptoms. We want to learn why some people get heart failure and how to better classify it for targeted treatments. We are recruiting volunteers with and without heart failure to learn more.
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Studying the Drug Metformin for Older Patients with Heart Failure
This study wants to see if the medicine Metformin XR can help older people with this heart problem. We also want to learn about the side effects and see if it can make their health better.
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New Treatment for ANCA Vasculitis in Kids and Teens
Active ANCA-associated Vasculitis is a disease where the body's immune system accidentally attacks its own small to medium-sized blood vessels. This makes the blood vessels swollen and damaged. The purpose of this study is to learn more about a treatment to help kids and teens with this disease. We want to see if the treatment called avacopan is safe and helpful.
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Rare Disease Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Studying a New Medicine for Crohn's Disease
The purpose of this study is to learn more about a new medicine for people with Crohn's disease who have not gotten better with other treatments. Volunteers in the study will get either the new medicine or a look-alike with no medicine in it. Our researchers will check if the new medicine works and is safe.
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A Study of the Drug ORIC-944 for Patients with Prostate Cancer
The purpose of this study is to learn more about the study drug ORIC-944. We want to see if this study drug is safe and useful to treat patients with prostate cancer that has spread to other areas of the body.
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A Study of New Treatment for Damaged Knee Cartilage
This study is testing a treatment called CARTISTEM® for people with knee cartilage damage and osteoarthritis. Researchers want to learn how safe it is and how well it works compared to a standard knee surgery used to treat damaged cartilage. This study is for volunteers with knee osteoarthritis diagnosed by their doctor.
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Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Studying the Drug SNDX-5613 for Patients with Acute Myeloid Leukemia
The study aims to learn more about the drug SNDX-5613. We want to find the best dose for patients with a blood cancer called acute myeloid leukemia. We also want to see how this drug works when used with two other drugs, daunorubicin and cytarabine.
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Studying a New Medicine for Children With JMML
The purpose of this study is to learn more about a medicine called trametinib. Researchers want to see if the medicine used with other cancer treatments, is safe and works well for children and young adults who were recently diagnosed with juvenile myelomonocytic leukemia (JMML). Researchers hope to find better treatment options for children with this rare blood cancer.
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Comparing Treatments for Patients with Newly Diagnosed AML
The purpose of this study is to see how well the study drug, CPX-351 works for treating acute myeloid leukemia. We want to find out if this approach works better than the usual approach. We also want to learn more about the possible side effects of this treatment.
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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
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Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying Cystic Fibrosis Treatments for People without Modulators
The purpose of this study is to collect health information and samples from people who have cystic fibrosis (CF). By doing this, researchers can learn more about CF and find new ways to treat it. We also want to help people with CF understand what it's like to be part of a research study. We are looking for volunteers who have CF and do not take a certain type of medicine called CFTR modulators.
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Studying New Treatments for High-Risk Multiple Myeloma
Researchers want to find out if new drug treatments work better than the usual treatment for people with high-risk multiple myeloma that was recently diagnosed. The study will compare different treatment options to learn which treatments are safest and most effective.
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Following Patients Taking Talvey for Multiple Myeloma
The purpose of this study is to learn about the experiences of people with multiple myeloma who are starting Talvey (talquetamab). Volunteers will complete surveys over one year to help researchers better understand quality of life, symptoms, and treatment experiences. This study is for people who have been prescribed Talvey but have not started treatment yet.
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