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Studying a New Device for Women with Overactive Bladder Symptoms
Overactive bladder is a health problem that makes it hard for a person to hold their urine and causes them to feel a strong need to go to the bathroom often. This study will see if a new device can help women with this problem. The device uses gentle heat to try to fix the nerves that cause these issues. Researchers will check if the device works better than no treatment.
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Studying the Medicine Depemokimab for COPD
Chronic obstructive pulmonary disease (COPD) is a lung disease that makes it hard to breathe because the airways are swollen and narrow. The purpose of this study is to learn more about a new medicine called depemokimab for people with COPD. Our researchers will compare it to a placebo (inactive shot) to see if it is safe and helps reduce flare-ups. The goal is to see if this medicine can help people breathe better and feel better.
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Studying Inhaled Treprostinil for Lung Disease
Progressive Pulmonary Fibrosis (PPF) is a lung disease where the lungs become damaged and scarred over time. This scarring makes the lungs stiff and harder to use. As a result, it can be harder to breathe. The purpose of this study is to learn more about a new medicine called inhaled Treprostinil. Researchers want to see if this medicine can help people with PPF improve their lung function.
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Studying Oxytocin for Pain Relief from Heat
The purpose of this study is to find out if oxytocin, a natural hormone, can help reduce pain from heat when given through the nose or a vein. People will get oxytocin in two different ways and have their pain measured. The goal is to find out which way works better for pain relief.
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Improving Sleep and Cognitive Health for People with Depression
The goal of this study is to see if improving sleep at night can help people with depression. Volunteers in this study will wear a headband while they sleep that is designed to improve deep sleep, the part of sleep that is important for healthy brain function. We hope that improved sleep can help with mood, memory, and attention. This study will involve three in-lab visits and will last about three weeks. Volunteers must be diagnosed with Major Depressive Disorder (MDD) and have some concerns about their memory or attention.
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Studying How Stress Affects Health in People Living with HIV
Many people living with HIV disease have stress in their lives that can negatively affect their health. The goal of this study is to understand how long-term stress changes how our brain and immune systems work. We also want to see how these changes affect our feelings, thoughts, and actions. By learning this, we hope to create better treatments for problems like depression and drug use. The study is open to individuals living with HIV.
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Improving Physical Function in Older Adults with Kidney Disease
The purpose of this study is to find out if two different programs can help older people with chronic kidney disease. One program involves exercise with quick movements 3 times per week for 12 weeks, and the other program involves taking classes on how to live a healthy lifestyle once per week for 12 weeks. Our researchers want to see if older people enjoy these programs and if they can be done safely. We are looking for volunteers who live within 20 miles of the Reynolda Campus.
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Studying the Medicine Axatilimab for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease is when the new cells from a transplant attack the patient's body and cause serious health problems. The purpose of this study is to find out if a new medicine called axatilimab, given with steroids, helps people with this disease.
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Studying the Medicine Axatilimab for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease is when the new cells from a transplant attack the patient's body and cause serious health problems. The purpose of this study is to find out if a new medicine called axatilimab, given with steroids, helps people with this disease.
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Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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Studying Two Treatments for Early Stage Breast Cancer
The purpose of this study is to learn more about adding chemotherapy to hormone treatment for breast cancer. We will compare two common treatments to see which works better. The goal is to find out if adding chemotherapy can prevent the cancer from returning and learn more about the possible side effects. We are looking for volunteers who have early-stage breast cancer, are HER2-negative, and have not gone through menopause yet.
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Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Studying a New Medicine for CIDP Nerve Disease
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a nerve disease that causes weakness and numbness. The purpose of this study is to learn more about a new medicine called TAK-881 for this disease. Everyone in the study will get TAK-881, and doctors will compare it to another medicine called HYQVIA. The goal is to find out if TAK-881 works better or is easier to use.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
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Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
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Cancer Cancer: Children, Teens Children, Infants, Teen Health
Understanding Pregnancy Experiences After Weight Loss Treatment
The purpose of this study is to learn how healthcare can better support women who are pregnant after weight loss treatment. We want to understand their goals for pregnancy and the challenges they may face. This study is for women in or near their third trimester who have had weight loss surgery or have taken a GLP-1 medicine in the past.
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Opinions, Social Issues Weight, Metabolism, Nutrition Women's Health
Studying a New Bladder Pain Treatment
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a condition that causes pain in the bladder and makes you feel like you need to pee often, even if your bladder is not full. The purpose of this study is to learn more about a new medicine called VNX001 for this condition. Our researchers want to learn if it is safe and works well for patients.
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Comparing Metformin and Insulin for Gestational Diabetes
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
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Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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