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Testing Cancer Drug Doses for Older Adults with Breast Cancer
The purpose of this study is to test two cancer drugs, palbociclib and ribociclib. We want to find the best dose for older adults with breast cancer. We want to help patients stay on treatment longer with fewer side effects. The study is for volunteers with hormone receptor-positive, HER2-negative breast cancer that has spread to another part of the body.
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Study of the Drug Inotuzumab Ozogamicin in Patients with Disseminated B-cell Lymphoblastic Lymphoma
The purpose of this study is to find out if the study drug, Inotuzumab Ozogamicin, can help treat certain types of leukemia. The study drug will be given along with the usual chemotherapy.
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CARES Study: Listening to Caregivers
The purpose of this study is to learn more about the health of caregivers. We want to understand how life experiences before and during caregiving for someone with dementia may impact physical and emotional health over time. The goal is to find better ways to help caregivers feel supported. This study is done completely over the phone. Volunteers will get one call for an interview and then a follow-up call to connect them to resources, if needed.
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Testing the Study Drug XmAb819 for Patients with Kidney Cancer
The purpose of this study is to test a new drug called XmAb819. We want to see if this study drug is safe and works well for volunteers with clear cell renal cell carcinoma that has come back or not responded to other treatments.
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Learning More About The Medicine Duvelisib T-cell Lymphoma
The purpose of this study is to learn more about treating peripheral T-cell lymphoma with the study drug Duvelisib or Azacitidine. One of the study drugs will be given along with the usual treatment. We want to see how well the combination treatment works. We also want to learn more about possible side effects.
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Studying the Drug SGR3515 for Patients with Advanced Solid Tumors
The study aims to learn about the drug SGR-3515. We want to see if it is safe and works well for treating advanced solid tumors. We also want to find the best dose and schedule for treating your cancer. We are looking for volunteers with advanced solid tumors who have either stopped benefiting from or cannot tolerate previous treatments, or whose cancer has returned.
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Learning How E-Cigarettes Affect Brain Health Over Time
The purpose of this study is to find out how using e-cigarettes for a long time affects the brain. We will compare people who switched to e-cigarettes with people who quit all tobacco and nicotine. The goal is to learn if switching to e-cigarettes helps the brain as much as quitting smoking.
Study Topics
Substance Use (Alcohol, Illegal Drugs, Tobacco) Brain and Memory
Studying a New Medicine for Certain Types of Heart Failure
The purpose of this study is to learn more about the study medicine called VS 041. We want to see if this medicine is safe for people with a certain type of heart failure called heart failure with preserved ejection fraction (HFpEF). Our researchers will also look at how this medicine affects blood markers linked to heart health. What we learn may help guide future treatments.
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Studying Opioid Use After Cancer Surgery
The purpose of this study is to see how many pain pills are taken by cancer patients after surgery. We also want to see how patients get rid of leftover pills and how happy they are with their care. We are looking for volunteers who are already scheduled to have surgery to remove their bladder, kidney, or prostate because of cancer at Atrium Health Wake Forest Baptist Comprehensive Cancer Center.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Cancer: Prostate Cancer: Urinary and Bladder
Studying a New Biomarker to Predict Breast Cancer Return
The goal of this study is to learn more about a new test called Oncodetect™. This test looks for signs of breast cancer in the blood. We want to see how well this test can find cancer coming back during and after treatments like surgery or radiation.
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Studying Plixorafenib for Cancers with BRAF Gene Changes
The purpose of this study is to learn more about the medicine plixorafenib. We want to see if this medicine can help people whose cancer has a change in the BRAF gene. The medicine is being studied to see if it works and if it is safe. People in the study will take the medicine and be watched closely for any changes or side effects.
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Studying New Treatment Timing for Advanced Cervical Cancer
The purpose of this study is to see if starting treatment with chemotherapy and immunotherapy before standard radiation treatment works better for advanced cervical cancer. Our researchers will compare two treatment plans to learn which one helps people live longer and keeps the cancer from getting worse. The study will also look at side effects and how safe the treatments are. This study is for volunteers with newly diagnosed advanced cervical cancer.
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Things that May Predict Memory Decline or Dementia in Adults (Healthy Brain Study)
This study is being done to look at changes in memory, thinking and brain structure in older adults. We will also study how the body processes sugar and how that may relate to change in brain function over time.
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Using a Blood Test to Guide Colon Cancer Treatment
The purpose of this study is to find out if a blood test can help doctors choose the best kind of chemotherapy for people who had surgery for colon cancer. This blood test looks for something called ctDNA. ctDNA is tiny pieces of DNA from cancer cells that can be found in your blood. We want to see if using this blood test is better or worse than the usual way of deciding on treatment. We are looking for volunteers who have colon cancer and have been treated with surgery.
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A Study of the Drug Reparixin for Patients with Myelofibrosis
The purpose of this study is to learn more about the study drug Reparixin. This study drug is for people with a type of blood cancer called myelofibrosis. We want to find out if Reparixin is safe and if it helps treat this cancer.
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Using Stereotactic Body Radiation Therapy to Treat Lung Cancer
The purpose of this study is to compare the usual treatment alone to using an additional treatment called Stereotactic Body Radiation Therapy plus the usual treatment.
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Exploring a New Program to Care for Rural Patients with Chronic Pain
The purpose of this study is to test a new program for patients in rural areas with chronic pain. We want to see if this program can help patients better manage their pain and daily functioning by working with a nurse care manager.
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Using a Tracker to Learn More about Heart Rate Variability Changes and Cancer-Related Tiredness
This study aims to help people with pancreatic and breast cancer who feel very tired because of their illness. We will use an activity tracker to check changes in your heart rate variability and how well you sleep. We will also ask you to fill out surveys and keep a diary about your tiredness. The information we collect may help us understand how heart rate variability changes are related to cancer-related tiredness. This study will last around 1 month.
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Using the TheraBionic Device to Treat Advanced Pancreatic Cancer
The purpose of this study is to find out how the TheraBionic device will affect pancreatic cancer. The TheraBionic device is a small portable device. We want to see if the device will prevent cancer growth.
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