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Quitting Smoking and Managing Daily Challenges
Study Topics
Healthy Volunteers Substance Use (Alcohol, Illegal Drugs, Tobacco)
Studying Two Medicines for Non-Small Cell Lung Cancer
The goal of this study is to learn how two medicines work together to treat non-small cell lung cancer. We want to find out if the medicines called amivantamab and Lazertinib are safe and helpful for people who have a certain change in a gene called EGFR.
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Improving Memory by Improving Sleep
Sleep is a critical part of long-term memory storage. Aging can cause issues with sleep and memory. The goal of this study is to see if improving sleep can improve memory. Volunteers will wear a headband during sleep that will record brain activity. This headband will also provide low-level electrical stimulation to increase deep sleep. Deep sleep is a stage of sleep that is important for memory.
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Helping Young Cancer Survivors Feel Better Using a Digital Tool
The purpose of this study is to learn more about a new digital tool to help adolescents and young adult cancer survivors manage their symptoms of depression. People in the study will use the tool, answer questions, and join a video call. The goal is to find out if the tool helps them manage their feelings better.
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Mental Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying a New COVID-19 Vaccine among Patients who have Received a Cell Therapy
The purpose of this study is to see if a new vaccine called GEO-CM04S1can help people who have received a cell therapy build protection from COVID-19. We want to compare this new vaccine to the current COVID-19 vaccines and see which one will work better.
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Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
Study Topics
Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
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Studying How Cancer Treatment Affects Thinking and Movement
The purpose of this study is to find out if people are okay with taking physical and thinking tests before and after cancer treatment. The treatments, like chemotherapy and surgery, can change how your body works and how well you think. Some people get better faster than others, but we do not know why. By looking at your test results before and after treatment, the researchers can see how the treatment affected you.
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Looking Into the Need of Blood Thinners as Treatment for Atrial Fibrillation
Blood thinning drugs are usually used to treat atrial fibrillation. Atrial fibrillation is when the heart has an irregular and often very fast heart rhythm. Blood thinners lower the risk of stroke but also increase the risk of bleeding. It may not be necessary for people who have short or infrequent atrial fibrillation to take blood thinners. The purpose of this study is to find out if it is safe to stop blood-thinning medication during long periods of normal heart rhythm.
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Studying New Medicine and Chemo for Rare Throat Cancer
The purpose of this study is to see if adding a new medicine called nivolumab to regular chemotherapy helps treat a rare throat cancer called nasopharyngeal carcinoma. We will also look at whether children can get less radiation and have fewer side effects. The goal is to find safer and better ways to treat this cancer.
Study Topics
Cancer Cancer: Children, Teens Cancer: Ear, Nose, Mouth, Throat
Studying a New Medicine for a Rare Blood Cancer - Chronic Myeloid Leukemia (CML)
The purpose of this study is to learn more about a medicine for a rare blood cancer called chronic myeloid leukemia. We want to see if the medicine TERN-701 can safely stop or slow down cancer. This study is for patients with chronic myeloid leukemia (CML) who have already tried other treatments that did not work or caused problems.
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Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
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Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Studying a New Vaccine for Infants and Toddlers
The purpose of this study is to learn about a new vaccine for healthy babies and toddlers. This vaccine is made to protect against a germ called pneumococcus, which can cause serious infections. The study will help researchers see how well the vaccine works and if it causes any side effects. We are looking for volunteers with a child who is 42 to 89 days old.
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Healthy Volunteers Infectious Diseases Screening and Prevention Children, Infants, Teen Health
Studying New Treatments for Multiple Myeloma That Came Back
The purpose of this study is to find better ways to treat a type of cancer called multiple myeloma. We want to see if using different mixes of medicines works better than the usual treatment for people whose cancer came back or did not get better with other treatments. We also want to learn which medicines help the most, and check for any side effects to make sure the treatments are safe.
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Treating Low-Risk, Early Stage Breast Cancer with Hormonal Therapy
The usual treatment for low-risk breast cancer is radiation and hormonal therapy. The purpose of this study is to find out how well hormonal therapy alone will work. We want to find out if this approach is better or worse than the usual approach.
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Testing the Addition of Radiation Therapy to the Usual Treatment for Advanced Stage Non-small Cell Lung Cancer
The purpose of this study is to find out if we can lower the chance of lung cancer growing or spreading by adding radiation therapy. The radiation therapy will be given along with the usual treatment. We want to find out if this approach is better or worse than the usual approach for lung cancer.
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Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
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