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Testing the Study Drug Tarlatamab for Lung Cancer
The purpose of this study is to test the study drug tarlatamab. We want to see if this study drug mixed with the drug durvalumab can help people with extensive-stage small-cell lung cancer. We will compare this combination to durvalumab alone. The goal is to see which treatment works better and is safer.
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The Vaccine Preferences Study
The goal of this study is to identify best practices in communicating information about new vaccines to communities that need them most. We want to survey Black and African American communities and learn more about their opinions and preferences for vaccine communication.
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Healthy Volunteers HIV/AIDS Infectious Diseases Mental Health
Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
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Testing the Study Drug RGX-314 for Patients with Vision Loss
The purpose of this study is to learn more about the drug RGX-314. We want to see if this drug helps people with an eye disease called neovascular age-related macular degeneration. We also want to see if this drug can make their vision better or keep it from getting worse.
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Learning More About Brain Health and Alzheimer's Disease
The purpose of this study is to learn more about brain health and the full spectrum of Alzheimer's disease from its earliest stages. This is an observational research study, which means it has no study drug or treatment.
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Testing a New Device for Treatment of Urine Leakage
The INTIBIA Tibial Nerve Stimulator is a medical device. The purpose of this study is to find out how well the device treats urge urinary incontinence (UUI). UUI makes it hard for someone to hold urine which causes urine leakage.
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How Damage to Blood Vessels in the Brain May Be Related to Thinking and Memory Problems Like Dementia
This study is being done to better understand how damaged blood vessels affect your thinking. This is not a treatment study.
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Taking Dasatinib and Quercetin Together to Help Slow the Progression of Alzheimer's (SToMP-AD Study)
The purpose of this study is to see how well a combination of meds may treat early Alzheimer's disease. The meds dasatinib and quercetin will be taken together.
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Finding the Best Timing for Surgery and Rehab for a Multiple Ligament Knee Injury
The purpose of this study is to find out if it's best to have surgery shortly after injury or wait. We also want to know if it is best to begin weight bearing and range of motion shortly after surgery or wait a few weeks.
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Study the Drug SNDX-5613 for Patients with Leukemia
The purpose of this study is to learn more about a drug called SNDX-5613. We want to see if this drug is safe and helpful when used with chemotherapy for people with a type of blood cancer called acute myeloid leukemia. We are looking for volunteers who are newly diagnosed and have not been treated before.
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Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
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Testing the Study Drug Inclisiran for Lowering Bad Cholesterol in Patients with Heart Disease
The purpose of this study is to learn more about the study drug Inclisiran. We want to see if this study drug is safe and useful for lowering bad cholesterol in patients with heart disease. We will compare using this study drug with usual care versus usual care alone.
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Testing the anti-cancer drug erdafitinib for brain cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
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Helping Young Cancer Patients with Fertility
The purpose of this study is to test a mobile tool called Fertilit-e. We want to see if this tool can help young adults with cancer learn about saving their ability to have children. The study focuses on African American and Hispanic young adults recently diagnosed with cancer. The goal is to make sure they get the right information and support.
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Learning More About How HIV and Marijuana Affect the Brain
The purpose of this study is to learn more about how HIV and marijuana affect the brain. This will help us understand how changes in the brain affect the way we think and behave.
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Healthy Volunteers HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco)
Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
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Can Metformin Help with Decline in Memory?
The purpose of this study is to see how well the medicine Metformin can help patients with memory decline.
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Virtual Reality Rehabilitation Method for Treating a Type of Vision Loss Called Visual Hemianopia
The purpose of this study is to see how well a new rehabilitation method works for treating visual hemianopia. Visual hemianopia is loss of half the vision in the right or left side of each eye. This rehabilitation may help restore vision.
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Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
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Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Effects of a Low-Carbohydrate and Low-Fat Diet in Adults with Mild Memory Loss (BEAT-AD Study)
The purpose of this study is to look at the effects of a low-carbohydrate diet and low-fat diet in adults with mild memory loss. We want to see if changes in diet can improve memory.
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