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Studying the Drug Tulisokibart for Patients with Active Crohn's Disease
The purpose of this study is to test a new drug called Tulisokibart. We want to see if this drug is safe and useful for people with Crohn's disease. We will compare this study drug to a placebo drug to see how well it works.
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How Cancer Treatment May Affect Brain Health
This study is looking at whether a cancer medicine called bevacizumab may cause small changes in the brain by raising blood pressure. Researchers will use brain scans and blood pressure checks to learn more about brain health in older adults with cancer. This study is for adults 60 and older diagnosed with gynecologic or colorectal cancer who are planning to receive bevacizumab as part of their cancer treatment.
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Studying Two Treatments for Early Stage Breast Cancer
The purpose of this study is to learn more about adding chemotherapy to hormone treatment for breast cancer. We will compare two common treatments to see which works better. The goal is to find out if adding chemotherapy can prevent the cancer from returning and learn more about the possible side effects. We are looking for volunteers who have early-stage breast cancer, are HER2-negative, and have not gone through menopause yet.
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Mobile App Support for Young Women with Breast Cancer
The purpose of this study is to look at a new way to better support young women with breast cancer. Our researchers will look at whether a mobile app can provide support and help lower stress. The app lets women connect with others and learn helpful information. This study is for volunteers who have been diagnosed with breast cancer at any stage.
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Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Testing a New Targeted Cancer Medicine for Gastrointestinal Stromal Tumors (GIST)
The purpose of this study is to learn more about a study drug called IDRX-42 (GSK6042981). We want to see if IDRX-42 works better than sunitinib, a medicine used to treat a type of cancer called gastrointestinal stromal tumor (GIST). This study is for people whose cancer has grown after treatment with imatinib or who had side effects that made it hard to take imatinib. Researchers will also learn more about the safety of IDRX-42 and how it affects people's symptoms and daily life. This information may help doctors find better treatments for people with GIST in the future. Volunteers must be adults with GIST that has spread to other parts of the body or cannot be removed with surgery. They must have received treatment with imatinib in the past. The study team will provide more information
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Studying a New Medicine for CIDP Nerve Disease
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a nerve disease that causes weakness and numbness. The purpose of this study is to learn more about a new medicine called TAK-881 for this disease. Everyone in the study will get TAK-881, and doctors will compare it to another medicine called HYQVIA. The goal is to find out if TAK-881 works better or is easier to use.
Study Topics
Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Studying the Oral Medicine Icotrokinra for Ulcerative Colitis
The purpose of this study is to learn more about the medicine Icotrokinra. Our researchers want to see if this medicine can safely control symptoms of ulcerative colitis. We also want to learn if this medicine can help people feel better and keep their disease under control over time.
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Study of DSP-5336 for Treatment of Leukemia
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
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Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Looking at Arm Size Differences in Kids with a Certain Type of Elbow Fracture
The purpose of this study is to gather information that might help us create a more accurate way to measure arm swelling when a child fractures their elbow. Using the same way to measure swelling might help doctors make decisions on treatment that can impact how kids heal from these types of injuries.
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Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
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Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
Study Topics
Cancer Cancer: Children, Teens Children, Infants, Teen Health
Understanding Pregnancy Experiences After Weight Loss Treatment
The purpose of this study is to learn how healthcare can better support women who are pregnant after weight loss treatment. We want to understand their goals for pregnancy and the challenges they may face. This study is for women in or near their third trimester who have had weight loss surgery or have taken a GLP-1 medicine in the past.
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Opinions, Social Issues Weight, Metabolism, Nutrition Women's Health
Studying How Genes Affect the Way Medicine Works for People
The purpose of this study is to learn more about how people's genes affect how they respond to medicine. We will collect cheek swabs or blood samples to be stored and used in future research. Information from this study may help doctors give better treatments to people in the future.
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Healthy Volunteers Screening and Prevention Wellness and Lifestyle Other
Studying a Type of Blood Test Used to Find Cancer in People With Sarcoma
The purpose of this study is to look at how well a special blood test called LP-WGS can find cancer in people with bone or soft tissue sarcoma (a type of cancer).
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Learning About Experiences with Healthcare to Improve Community Health
The purpose of this study is to help improve community health. Our researchers want to learn about people’s experiences with healthcare, especially for those who use substances. Sharing your story can help improve care and support for others in your community. This study is for volunteers who have used stimulants or opioids in the past year.
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Learning About Experiences with Healthcare to Improve Community Health
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
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Studying Two Medicine Combinations for Chronic Lymphocytic Leukemia
The purpose of this study is to compare the combination of sonrotoclax and zanubrutinib against the combination of venetoclax and acalabrutinib. Researchers want to learn which combination works better and is safe for treating chronic lymphocytic leukemia (CLL).
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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