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A Study of Telehealth to Treat Children with Medical Complexity
The purpose of this study is to learn more about using telehealth visits for children with medical complexity. We want to find out if telehealth visits can improve the health of children with chronic health problems.
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Learning More About How Gut Micro-organisms Play a Role in Prostate Cancer
The purpose of this study is to find out how the gut micro-organisms may affect prostate cancer that spreads to the bone. In this study, the methods required to study these gut-bone interactions will be developed and tested.
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Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
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Treating Focal Onset Epilepsy with Study Drug BHV-7000
The purpose of this study is to find out how well the study drug, BHV-7000, works for treating focal seizures. We also want to learn more about side effects that may be caused by the study drug.
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A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
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Understanding How Chemotherapy Treatment Before Surgery Impacts Recovery
The purpose of this study is to learn how chemotherapy treatment before surgery affects your body and brain. Some people get chemotherapy before surgery, and some get it after. By looking at changes in health, doctors hope to understand how chemotherapy before surgery helps people feel better and recover faster. We are looking for volunteers who have recently been diagnosed with a gynecological cancer (ovarian, peritoneal, fallopian tube, or endometrial) and are planning to receive chemotherapy treatment followed by surgery afterwards.
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Studying New Treatments for Children and Young Adults With Relapsed B-ALL
The purpose of this study is to look at a new way to treat a blood cancer called B-ALL that has come back after prior treatment. Researchers will see if the medicine combination of blinatumomab and nivolumab is more effective than blinatumomab alone. The goal is to find safer treatments that help people stay healthy longer.
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Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
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Studying a New Medicine to Help People with Type 2 Diabetes Lose Weight and Manage Blood Sugar
The purpose of this study is to see if a new medicine can help people with type 2 diabetes who are overweight or obese lose weight safely and better manage their blood sugar. Our researchers will compare the new medicine to a placebo (looks the same, but does not have medicine in it) to see how well it works and if it is safe. The medicine will be given along with a healthy eating and increased physical exercise program.
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Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
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Studying a New Way to Prevent Blood Clots During Medical Procedures
The goal of this study is to help people who need medical procedures where their blood goes outside their body, like during dialysis or heart surgery. We want to find a way to stop blood clots during these procedures. This study will help us learn how to prevent clots and make these procedures safer. We are looking for healthy volunteers, both adults and children, who are 17-70 years old and weigh over 110 pounds.
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Studying a New Medicine to Help People with COPD
The goal of this study is to see if a new medicine called lunsekimig can help people with COPD feel better. It will look at how well the medicine works for people who still have breathing problems even though they are already getting treatment. The study will also check if the medicine causes any side effects.
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Studying a New Medicine for People with Heart Disease and Obesity
Atherosclerotic cardiovascular disease happens when fatty buildup blocks blood vessels and makes it harder for blood to flow. The purpose of this study is to learn more about a new medicine for people who already have this condition and are overweight or have obesity. The goal is to see if the medicine can help lower their chances of having heart problems in the future.
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Using Brain Scans to Track Brain Tumor Changes
The purpose of this study is to learn if special brain scans can give doctors better information about how brain tumors change over time. We will compare regular MRI scans with special MRI scans and, for some people, a PET scan. What we learn may help doctors care for future patients with brain cancer. This study is for volunteers diagnosed with glioblastoma.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying the Medicine VX-670 for Myotonic Dystrophy Type 1
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Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Learning How the Brain Shifts Attention
The purpose of this study is to learn how people move their attention when they see different things. We will use computer tasks and brain scans to see how your brain works when you pay attention to new things. The goal is to help scientists understand how attention changes in the brain.
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Studying a New Device for Women with Overactive Bladder Symptoms
Overactive bladder is a health problem that makes it hard for a person to hold their urine and causes them to feel a strong need to go to the bathroom often. This study will see if a new device can help women with this problem. The device uses gentle heat to try to fix the nerves that cause these issues. Researchers will check if the device works better than no treatment.
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Development of a Tool to Help Caregivers Check Car Seat Installation
The purpose of this study is to create a tool that can use a short phone video to check if a child's car seat is installed correctly. Many car seats are not used the right way, even though most parents think they are. We are looking for parents and caregivers of children who ride in forward-facing car seats to help us build this tool. If you join, we will record short videos of your car seat before and after a free safety check by a certified child passenger safety technician with and without your child in the car seat.
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Screening and Prevention Other Children, Infants, Teen Health
Studying the Medicine Depemokimab for COPD
Chronic obstructive pulmonary disease (COPD) is a lung disease that makes it hard to breathe because the airways are swollen and narrow. The purpose of this study is to learn more about a new medicine called depemokimab for people with COPD. Our researchers will compare it to a placebo (inactive shot) to see if it is safe and helps reduce flare-ups. The goal is to see if this medicine can help people breathe better and feel better.
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Improving Sleep and Cognitive Health for People with Depression
The goal of this study is to see if improving sleep at night can help people with depression. Volunteers in this study will wear a headband while they sleep that is designed to improve deep sleep, the part of sleep that is important for healthy brain function. We hope that improved sleep can help with mood, memory, and attention. This study will involve three in-lab visits and will last about three weeks. Volunteers must be diagnosed with Major Depressive Disorder (MDD) and have some concerns about their memory or attention.
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