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Studying Ublituximab for Patients with Multiple Sclerosis
The purpose of this study is to find out how well the medicine Ublituximab works for people with relapsing multiple sclerosis. Our researchers also want to see if the medicine is safe and easy to take when given in shorter amounts of time.
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Studying Ablative Local Therapy for Colorectal Cancer
The purpose of this study is to learn if adding special tumor treatments, called ablative local therapy, can help people with colorectal cancer that has spread. These treatments may use surgery, radiation, or heat to target all tumor spots. The goal is to see if adding these treatments to usual cancer medicine helps people live longer.
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Studying a New Treatment Combination for Mantle Cell Lymphoma
The purpose of this study is to learn more about a new medicine combination to help patients with a type of blood cancer called mantle cell lymphoma. We want to see if a new medicine called sonrotoclax combined with the medicine zanubrutinib works better than zanubrutinib alone. Volunteers in the study will be randomly assigned to get either the new medicine or a placebo along with zanubrutinib.
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Studying Etentamig for Patients with Multiple Myeloma
The purpose of this study is to learn more about the medicine etentamig. We want to see if this medicine is safe and helpful for people with multiple myeloma. Our researchers will also study how the medicine works in the body, and what they learn may help improve future treatment for this cancer.
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Using Brain Scans to Help Predict Brain Cancer Changes
The purpose of this study is to learn how different brain scans can show changes in brain cancer. The goal is to see if special MRI and PET scans can give doctors better information than regular scans. This may help doctors understand how tumors grow and how patients respond to treatment. This study is for volunteers with glioblastoma that is IDH‑wild type.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying New Treatments for Advanced Breast Cancer
The purpose of this study is to learn more about a new drug, MK-2870, alone or with another drug called pembrolizumab. We want to see how well they work compared to standard chemotherapy. The goal is to find out which treatment helps people live longer and feel better. This study is for volunteers with advanced breast cancer that cannot be removed by surgery.
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Studying a New Medicine for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) is a condition where the donor's cells from a stem cell transplant attack the patient's body, thinking it is not their own. The purpose of this study is to learn more about a new medicine called vimseltinib to see if it is safe and helps people with this condition. The medicine may help by calming down the immune system. Researchers want to find the best dose with the fewest side effects.
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Allergies and Immunity Skin, Hair, Nails Bones, Joints, Muscles
Studying a New Medicine for B-cell Non-Hodgkin Lymphoma
The purpose of this study is to learn more about a new medicine called AZD0486. This medicine is for people with a type of cancer called B-cell non-Hodgkin lymphoma that has come back or did not get better with other treatments. The goal is to see if this medicine is safe and if it helps shrink or stop the cancer.
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Studying the Drug CB-011 for Treatment of Multiple Myeloma
The purpose of this study is to learn more about the study drug CB-01. We want to see if it is safe and helpful for treating people with a type of blood cancer called multiple myeloma that has come back or did not respond to other treatments. This drug uses special cells from a healthy donor to find and kill cancer cells.
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Studying the Medicine BLEXIMENIB for Patients with Acute Myeloid Leukemia
The purpose of this study is to learn more about a new medicine called BLEXIMENIB. We want to see if it works better when added to two other medicines for people with a kind of blood cancer called acute myeloid leukemia (AML). This study is for people with changes in the KMT2A or NPM1 gene, who are not able to get stronger chemotherapy.
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Studying Brain Cell Treatment to Help Stop Hard-to-Control Seizures
Drug-resistant bilateral mesial temporal lobe epilepsy means a person has seizures in both sides of the brain's memory area that do not get better with medicine. The purpose of this study is to learn more about a new treatment made from special brain cells to help people with this type of epilepsy. Doctors will place these cells into the brain to see if they can safely reduce seizures. The study also checks how well people feel after getting the treatment.
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Early Detection Matters
The purpose of this study is to test recruitment methods to find and sign up people for a blood screening study. The results will help us decide if we can do a bigger study later. You are invited to join because you are at least 30 years old, self-identify as Black and/or African American or are at higher risk for developing MGUS because of a first-degree relative and, live in Charlotte, NC or nearby. This study will also check how many people have a blood condition that might lead to blood cancer.
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Minority Health Screening and Prevention Cancer Cancer: Blood
Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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Studying Vitamin C Levels and Blood Cancer Treatment Outcomes
The purpose of this study is to see if vitamin C levels affect how well treatments work for people with certain types of blood cancer. We will also look at specific genes that might affect vitamin C in the body. This study will help us understand if vitamin C can improve treatment results for these cancers. We are looking for volunteers with acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia.
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Adding Metformin to Standard Treatment for Soft Tissue Sarcoma
The purpose of this study is to learn if adding metformin to standard cancer treatment can help people with advanced soft tissue sarcoma. Researchers want to see if this combination may improve outcomes compared to usual treatment alone. This study is for volunteers diagnosed with advanced or metastatic soft tissue sarcoma that cannot be removed with surgery.
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Using a Blood Test to Track Cervical Cancer Treatment Response
The purpose of this study is to learn more about a blood test called circulating tumor DNA (ctDNA) in people with locally advanced cervical cancer. Our researchers want to see how ctDNA levels change during and after chemotherapy and radiation treatment. The goal is to learn if this blood test can help track how well treatment is working.
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Studying Diabetes Medicine for Heart and Kidney Health
The purpose of this study is to learn more about two types of diabetes medicines. We want to see which medicine type helps lower the risk of heart and kidney problems. We are looking for volunteers with type 2 diabetes and a history of heart disease or have high risk for heart disease that are patients of Elizabeth Internal Medicine and Carmel Family Physicians.
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Helping Patients with Cancer Quit Smoking With New Therapy
The purpose of this study is to learn more about a kind of therapy called Dialectical Behavior Therapy Skills Training (DBT-ST). We want to see if this therapy can help people with cancer who smoke to smoke less or quit. We want to find out how it affects their feelings, stress, and how they deal with tough situations. We will also see if people with cancer who smoke would be willing to try this therapy if it were part of their regular care.
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Substance Use (Alcohol, Illegal Drugs, Tobacco) Wellness and Lifestyle Cancer
Studying Injuries From Motor Vehicle and Nonmotorist/Pedestrian Crashes
The purpose of this study is to learn about the causes of injuries in motor vehicle and nonmotorist/pedestrian crashes. We hope that the information we learn from this study will benefit you and others in the future by helping us design and build safer vehicles to prevent injuries and save lives. There will be no change to the care that you are receiving, and your health and vehicle information is protected and will not be disclosed. We are looking for volunteers who have recently been in a motor vehicle or nonmotorist/pedestrian crash with moderate to severe injuries.
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Studying a New Medicine for Multiple Myeloma
The purpose of this study is to learn about the study medicine ABBV-453. We want to see if this medicine is safe and helpful for patients with Multiple Myeloma. The study team will provide more information.
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