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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
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Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Studying New Treatments for Head and Neck Cancer Patients
The goal of this study is to find out more about a new treatment for people with head and neck cancer. We want to see if using a treatment called Petosemtamab along with another treatment called pembrolizumab can help stop the cancer from growing or spreading and make patients feel better. We are looking for volunteers who have head and neck cancer that has spread to other parts of their body or has not gotten better with other treatments. The study team will give more details.
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Testing a New Study Device for Mitral Valve Regurgitation
The purpose of this study is to test a study device called the CardioMech Mitral Valve Repair System for patients with this condition. We want to learn about the safety and effectiveness of this device.
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Studying a New Cell Therapy for Patients with Newly Diagnosed Multiple Myeloma
The purpose of this study is to learn more about a new medicine for patients with uncontrolled asthma. We want to see if the medicine called AZD8630 is safe and works well when used with an inhaler. Findings from this study may help other patients with asthma and other lung conditions in the future.
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Studying a New Asthma Medicine for Adults
The purpose of this study is to learn more about a new medicine for patients with uncontrolled asthma. We want to see if the medicine called AZD8630 is safe and works well when used with an inhaler. Findings from this study may help other patients with asthma and other lung conditions in the future.
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Using the Study Drugs Atezolizumab and Bevacizumab to Treat Liver Cancer
The study wants to learn more about a drug called Atezolizumab. We want to see how well it treats liver cancer by itself and when used with another drug called Bevacizumab. We also want to know if these treatments are better or worse than the usual treatment. Volunteers must have advanced liver cancer that can't be removed by surgery.
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Testing a New Device for Pelvic Prolapse
The purpose of this study is to test a new device called the Reia System. We want to see if the device is safe and useful for women with pelvic organ prolapse when used at home. We are looking for volunteers who have not used a pessary before.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Reducing Infection Risk in C-Section Deliveries
The goal of this study is to find a way to lower the chance of getting an infection after a C-section. We want to see if using two antibiotics instead of one before the C-section can help prevent infections like endometritis, wound infection, or sepsis. We are looking for volunteers who are at least 23 weeks pregnant and are planning to have a C-section.
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Testing Study Drugs for Advanced Solid Tumors
The purpose of this study is to learn more about study drugs to help treat patients with advanced solid tumors. The study drugs being tested are GSK4381562, dostarlimab and belrestotug. We will try different combinations of these drugs to see if they are safe and work well.
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Studying a New Endometrial Cancer Medicine
The goal of this study is to learn about a new cancer medicine called Sacituzumab Govitecan. This medicine is for patients whose endometrial cancer has returned. We want to find out if this medicine can help patients live longer and slow down or stop their cancer from growing. We will compare this medicine to regular chemotherapy treatments like doxorubicin or paclitaxel.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Learning More About Treating Cancer Near the Spinal Cord with Radiosurgery and Pembrolizumab
The purpose of this study is to find out what effects pembrolizumab and radiosurgery may have on you and your cancer. We want to see if this treatment can reduce the size of cancer that has spread near the spinal cord. Radiosurgery involves radiation in a large dose to destroy your cancer. It does not involve cutting your tumor out.
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Brain Changes after Radiation Treatment for Glioma
Glioma is a type of brain cancer. The purpose of this study is to see if we can predict how brain function will change after radiation treatment for glioma. We will be doing PET scans and blood tests with glioma patients. A PET scan is a type of test that gives us images of your brain and can help detect certain diseases.
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The Osteoarthritis Prevention Study (TOPS)
Exercise and diet have been shown to help with the treatment of osteoarthritis. The purpose of this study is to find out if exercise and diet prevents osteoarthritis.
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Arthritis, Lupus, and Autoimmune Disorders Weight, Metabolism, Nutrition
Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Finding a Way to Predict Success or Failure of Treatment for Atopic Dermatitis and Psoriasis
There are a number of treatments for psoriasis and atopic dermatitis. This has created a need to find a way to figure out which treatment will work best for each patient. The goal of this study is to develop a test that can predict treatment success and/or failure. If you take part in this study, no changes will be made to your treatment for psoriasis or atopic dermatitis.
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