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Using a Small Device to Track Muscle Changes in ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly makes muscles weaker and harder to control, making it tough to walk, talk, or breathe. The purpose of this study is to see how a small device called the mScan can measure muscle changes in people with ALS. The device uses a tiny, painless electrical signal to check muscles. Our researchers hope this will help track ALS over time and see how well treatments work.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Comparing Two Medicines for Brain Cancer
The purpose of this study is to find out which medicine works better for people who have a type of brain cancer called glioblastoma. We will compare the medicine niraparib and temozolomide, along with radiation therapy. The goal is to see which treatment helps more and is safer.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
Study Topics
Studying a New Medicine for Severe Heart Failure
The purpose of this study is to find out if a new medicine called omecamtiv mecarbil can help people with serious heart failure. The medicine may help the heart pump better and lower the chance of problems like hospital visits or other serious health issues. We hope this research will help doctors treat heart failure in the future.
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Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
Study Topics
Studying the Medicine Remibrutinib for a Chronic Skin Condition
Hidradenitis suppurativa is a skin disease that causes painful lumps under the skin, often in areas like the armpits or groin. The purpose of this study is to see if the medicine remibrutinib can help adults with this disease. We want to see if the medicine can safely improve symptoms and improve overall health and well-being.
Study Topics
Studying the Medicine Bitopertin for Sun Sensitivity
Erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP) are rare disorders that are passed down in families and cause a chemical to build up in the blood. This makes being in sunlight hurt their skin and can also affect their liver. The purpose of this study is to find out if a new medicine called bitopertin can help people with EPP or XLP stay in the sun longer without pain.
Study Topics
Studying a Lower Dose of Tamoxifen for Breast Cancer
The purpose of this study is to see if a lower dose of tamoxifen works as well as the regular dose to treat early-stage breast cancer. Tamoxifen is a medicine that helps stop cancer from coming back. Our researchers will also look at whether the lower dose causes fewer side effects for patients.
Study Topics
Studying the Medicine CREXONT for Parkinson's Disease
The purpose of this study is to learn more about the medicine CREXONT. We want to see if this medicine is safe and useful for patients with Parkinson's disease in their daily lives.
Study Topics
Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
Study Topics
Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying Care Choices After Breast Cancer Surgery
The purpose of this study is to compare two different approaches to care for breast cancer after surgery. Our researchers want to find out whether closely monitoring patients after surgery works just as well as giving additional medication to prevent the cancer from returning. This study is for volunteers who had triple-negative breast cancer and showed no signs of cancer after completing chemotherapy and surgery. The results will help doctors determine the best way to care for patients in this situation.
Study Topics
Studying the Medicine IDP-023 for Blood Cancer
The purpose of this study is to learn more about a new medicine called IDP-023. We want to see if it is safe and if it can help people with certain blood cancers. We are looking for volunteers who have multiple myeloma that came back after trying at least three other cancer treatments, non-Hodgkin's lymphoma that came back after trying at least two other treatments, or acute myeloid leukemia that came back after trying at least one other treatment.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Studying a Rare Blood Condition Over Time
The purpose of this study is to learn more about a rare blood problem called plasminogen deficiency. Researchers will collect blood, urine, and health information to find out who gets symptoms and how to help them. The goal is to improve care for people with this condition.
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Studying Radiation vs Usual Care for Cancer that Spread to Bones
The purpose of this study is to help patients who have cancer that has spread to their bones but is not causing pain yet. We want to find out if giving radiation therapy before symptoms start can help prevent problems from bone cancer. Volunteers in this study will either get the usual care or the usual care plus radiation. The goal is to see which option works better to stop bone problems like fractures or spinal cord issues.
Study Topics
Cancer Cancer: Men's Cancer Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Solid Tumor Cancer: Women's Cancer
Studying the Medicine Erdafitinib for Brain Cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
Study Topics
Studying the Supplement Fisetin to Help Cancer Survivors with Tiredness
The purpose of this study is to learn more about fisetin, a dietary supplement. We want to find out if this supplement can help reduce tiredness in people who have had cancer treatments. We will compare this supplement to a placebo. We are looking for volunteers who previously had cancer treatments that often cause tiredness. The study team will provide more information.
Study Topics
Studying New Drug Combinations for Advanced Small Cell Lung Cancer
The purpose of this study is to find the highest safe dose of a new drug, iadademstat, when used with other cancer drugs (atezolizumab or durvalumab) in people with advanced small cell lung cancer. The study will check for side effects and see how well the drug combination works. This may help doctors learn if this new treatment is better or worse than the usual care for this cancer.
Study Topics
Finding the Best Blood Cancer Treatment Using Blood Tests
The purpose of this study is to find out if doctors can quickly test blood and bone marrow to look for signs that help choose the best cancer treatment. These signs, called markers, can show which treatments might work best. If your test shows certain markers, you might be able to join a special treatment group. If not, your doctor will give you the usual care. We are looking for volunteers who have previously untreated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
Study Topics
Studying Access to Food and its Impact on Blood Pressure
The purpose of this study is to learn more about access to food and blood pressure. Our researchers would like to explore different ways of helping people get better access to food and see if it can help improve their blood pressure. Some people will get help from a community health worker, and others may get meals made for people with high blood pressure. The goal is to find out which way works best. We are looking for volunteers who have high blood pressure and experience a lack of regular access to food.
Study Topics
Opinions, Social Issues Weight, Metabolism, Nutrition Wellness and Lifestyle Blood Pressure
Helping the Brain Relax to Improve Sleep and Stress
The purpose of this study is to learn more about a new technology called Cereset Research (CR). It uses sounds linked to your brainwaves to help your brain relax and balance. In this study, you will continue your other current care, but will also receive sessions of CR. The goal is to see if it helps people with stress, anxiety, or trouble sleeping. We are looking for volunteers with symptoms following a concussion or traumatic brain injury (TBI), ongoing symptoms of long-COVID, or a functional movement disorder.
Study Topics