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Improving Sleep and Cognitive Health for People with Depression
The goal of this study is to see if improving sleep at night can help people with depression. Volunteers in this study will wear a headband while they sleep that is designed to improve deep sleep, the part of sleep that is important for healthy brain function. We hope that improved sleep can help with mood, memory, and attention. This study will involve three in-lab visits and will last about three weeks. Volunteers must be diagnosed with Major Depressive Disorder (MDD) and have some concerns about their memory or attention.
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Studying How Stress Affects Health in People Living with HIV
Many people living with HIV disease have stress in their lives that can negatively affect their health. The goal of this study is to understand how long-term stress changes how our brain and immune systems work. We also want to see how these changes affect our feelings, thoughts, and actions. By learning this, we hope to create better treatments for problems like depression and drug use. The study is open to individuals living with HIV.
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Helping Young People Manage Sickle Cell Pain
The purpose of this study is to see how Cognitive Behavioral Therapy (CBT) helps with pain in people who have sickle cell disease. We also want to see if self-guided CBT or CBT with the help of a health coach is better. In this study, a health coach is a peer or someone who is either living with or a caregiver of someone living with sickle cell disease.
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Improving Physical Function in Older Adults with Kidney Disease
The purpose of this study is to find out if two different programs can help older people with chronic kidney disease. One program involves exercise with quick movements 3 times per week for 12 weeks, and the other program involves taking classes on how to live a healthy lifestyle once per week for 12 weeks. Our researchers want to see if older people enjoy these programs and if they can be done safely. We are looking for volunteers who live within 20 miles of the Reynolda Campus.
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Studying the Medicine Axatilimab for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease is when the new cells from a transplant attack the patient's body and cause serious health problems. The purpose of this study is to find out if a new medicine called axatilimab, given with steroids, helps people with this disease.
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Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
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Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Studying a New Hepatitis B Blood Test
The purpose of this study is to find out how well a new rapid blood test can detect hepatitis B infection. Researchers will compare the test results to standard laboratory testing to see how accurate and easy the test is to use in healthcare settings. This study is for volunteers who are experiencing signs or symptoms that may be related to hepatitis and have a history of factors that may increase the chance of hepatitis B infection.
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Studying a New CAR T Treatment for Multiple Myeloma
The purpose of this study is to learn more about a new treatment called arlo‑cel for people with multiple myeloma. The study will compare this new treatment to standard cancer medicines to see which works better and is safer. This study is for volunteers with multiple myeloma whose cancer came back or did not improve after other treatments.
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Can Vibegron Improve Health in Older Adults With Obesity?
This study is testing whether an FDA-approved medication called vibegron can improve energy use, physical function, memory, and overall health in adults ages 50 to 70 who have obesity. Researchers will compare vibegron to a placebo to learn if it may help reduce health problems linked to aging and obesity.
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Understanding Needs of Young People With Cancer
This study aims to learn what young people with cancer need most while getting care and after treatment. We want to understand what topics they want more education and support about, such as health, emotions, and daily life. What we learn will help improve programs and services for young people with cancer. We are looking for volunteers who were between 15 and 39 years old when they were diagnosed with cancer and are currently getting cancer treatment or have had cancer treatment in the past.
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Finding and Treating Early Heart Artery Plaque
The purpose of this study is to find adults who may have early plaque buildup in their heart arteries before they develop heart disease symptoms. Researchers also want to learn whether lifestyle support and study medicines can help slow or reduce plaque buildup over time. This study is for men ages 30 to 50 or women ages 40 to 60 with low 10-year risk of heart disease with several risk factors or known calcified plaque.
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Studying a New Medicine to Treat BK Virus Infection
The purpose of this study is to test a new medicine called AIC263029 to see if it can help treat BK virus infection in people who have had a kidney transplant. They want to learn how well the medicine works and how safe it is. The information from this study may help improve treatment for people with BK virus in the future.
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Studying a New Implant for Stress Urinary Incontinence
Stress Urinary Incontinence (SUI) is a common type of urine leakage among men. The purpose of this study is to test how safe and how well a new implanted device works for this condition. The device is designed to help men who leak urine during activities like coughing or exercising. Our researchers want to see if it can reduce urine leaks and improve daily life. We are looking for male volunteers who have been diagnosed with SUI for at least 6 months.
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Testing a New Treatment for Myeloproliferative Disorders
The purpose of this study is to see how well the study drug, INCA033989, works for treating myeloproliferative disorders. We want to find what effects, if any, this therapy may have on people. We also want to find out what is the highest dose that can be given without causing severe side effects.
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Communities Against Cancer: A Survey for Change
The purpose of this study is to learn about how people in our area take care of their health and what challenges they face with cancer. We hope to understand what people need and how we can help them better. The answers from this survey will help us make plans to support our community.
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Men's Health Opinions, Social Issues Screening and Prevention Wellness and Lifestyle Women's Health Cancer Other
Tracking Asthma Treatment With Depemokimab in Everyday Life
This study is for adults with asthma caused by type 2 inflammation who are starting depemokimab as part of their regular care. Researchers want to learn how well depemokimab works in everyday healthcare settings and how it affects asthma symptoms, asthma attacks, quality of life, and healthcare use over time.
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Studying a New Medicine to Help People With ATTR Heart Disease
ATTR amyloidosis is a disease where a protein called transthyretin builds up in the body and causes problems, especially in the heart and nerves. The purpose of this study is to learn more about a new medicine called nucresiran to help people with this disease.
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Studying the Medicine KQB54 for Previously Treated Pancreas, Colon, or Non-Small Cell Lung Cancer that Has Spread
The purpose of this study is to learn more about a medicine called KQB548. Our researchers want to see if the medicine can safely help people with an advanced solid tumor that has a KRAS G12D mutation. They also want to learn if the medicine is safe and find the best dose to use, while also seeing how it affects cancer growth.
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Studying the Medicine Migalastat for Children with Fabry Disease
Fabry disease is a rare genetic condition where the body cannot break down certain fats, causing them to build up and damage organs like the heart, kidneys, and nerves. The purpose of this study is to learn more about the medicine migalastat for this condition. Our researchers want to see if it is safe and helpful for children.
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Genetic Disorders Rare Disease Children, Infants, Teen Health
Comparing Two Medicines for ALK‑Positive Lung Cancer
The purpose of this study is to learn more about a new medicine called NVL‑655 for non‑small cell lung cancer that is ALK‑positive. Our researchers want to see if NVL‑655 works better and is safer than a commonly used medicine called alectinib. The goal is to learn which treatment helps stop the cancer from getting worse for a longer time.
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