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Using a Tracker to Learn More about Heart Rate Variability Changes and Cancer-Related Tiredness
This study aims to help people with pancreatic and breast cancer who feel very tired because of their illness. We will use an activity tracker to check changes in your heart rate variability and how well you sleep. We will also ask you to fill out surveys and keep a diary about your tiredness. The information we collect may help us understand how heart rate variability changes are related to cancer-related tiredness. This study will last around 1 month.
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Comparing Different Heart Procedures for Clogged Arteries
Multivessel coronary artery disease is a disease that causes blockages in the blood vessels supplying the heart muscle. The purpose of this study is to compare two common heart procedures to see which one works better for this disease. One uses a small tube and balloon to open clogged heart arteries. The other is surgery to go around the clogged parts. The goal is to see which one helps people live longer and feel better.
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Studying Extra Therapies People Use During Cancer Treatment
The purpose of this study to learn more about other ways people manage their cancer symptoms while they are getting treatment. These other ways include using things like cannabis (also called marijuana), vitamins or supplements, and doing activities like acupuncture or meditation. We want to find out if these methods help or hurt people compared to the usual care they get from their doctor.
Study Topics
Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Lung Cancer: Lymphoma Cancer: Skin
Studying a New Treatment to Help Stop High‑Risk Bladder Tumors
The purpose of this study is to learn more about a new treatment for people with bladder cancer that has not spread into the muscle but could become more serious over time. This is called high-risk, non-muscle invasive bladder cancer (NMIBC). Our researchers want to see if a treatment called cretostimogene grenadenorepvec can safely kill cancer cells, stop the tumor from coming back, and for how long it can help.
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Studying Ninerafaxstat for Thickened Heart Muscle
Non obstructive hypertrophic cardiomyopathy (nHCM) is a heart condition where the heart muscle is thicker than it should be. This can make it harder for the heart to pump blood and can cause symptoms. The purpose of this study is to learn more about a study medicine called ninerafaxstat. Researchers want to see if this medicine is safe and if it helps the heart work better during daily activities and exercise.
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Studying Digoxin to Help Treat Brain Cancer
The purpose of this study is to learn more about a medicine called digoxin. We want to see if this medicine can help stop a type of brain cancer called medulloblastoma from getting worse. The goal is to learn if this treatment can help and to understand any side effects it may cause. We are looking for volunteers who have been diagnosed with medulloblastoma.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers Children, Infants, Teen Health
Testing the Study Drug Olvi-Vec for Ovarian Cancer that Resists Treatment
The purpose of this study is to learn about the drug Olvi-Vec. We want to see if it is safe and helpful for treating ovarian, fallopian tube, or peritoneal cancer that did not get better with a type of treatment called platinum-based chemotherapy.
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Studying Treatment Options for Multiple Myeloma After a Stem Cell Transplant
The purpose of this study is to find out which treatment works best to keep multiple myeloma from coming back after a stem cell transplant. Our researchers will compare three options: a new medicine called teclistamab with standard treatment called lenalidomide, lenalidomide alone, or teclistamab alone. The goal is to see which treatment helps people stay healthy longer.
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Studying a New Medicine for Generalized Myasthenia Gravis
Acetylcholine receptor antibody positive generalized myasthenia gravis (AChR+ gMG) is a disease where the body's immune system attacks the places where nerves talk to muscles, making the muscles weak and tired. The purpose of the study is to learn more about a new medicine and see how well it helps people in their everyday activities.
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Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
Helping Improve Breast Cancer Care for Young Women
The purpose of this study is to learn more about breast cancer in younger women and help improve care in the future. Researchers will collect blood, tissue, and stool samples from women who were diagnosed with breast cancer between the ages of 18 and 45. They will look for patterns and differences to help guide future research and treatment.
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Collecting Samples to Learn About Childhood Cancer
The purpose of this study is to find better treatments in the future for children with cancer. We want to create a large collection of blood and tissue samples from children cancer to help doctors learn more about how cancer and the immune system work together. Information from this study may help us find better ways to treat cancer in the future. We are looking for volunteers who have been diagnosed with any type of pediatric cancer and are under the care of a doctor at Atrium Health.
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Using NK Cells to Treat Sarcoma
The purpose of this study is to see if adding a special type of immune cell called "natural killer" (NK) cells to chemotherapy can help treat cancer better. NK cells are good at finding and killing cancer cells.
Study Topics
Cancer Cancer: Children, Teens Cancer: Sarcoma (Bone, Muscle, Soft Tissue)
Studying Blood Particles to Help Treat Cancer
The purpose of this study is to learn more about tiny particles in the blood called extracellular vesicles. By studying this, we hope to find out more about different types of cancer and how to treat them better. We will look at the blood samples from patients with similar cancers to see if we can discover new information. This could help doctors choose the best treatments for cancer patients in the future. We are looking for volunteers with urothelial, prostate, or kidney cancer. The study team will provide more information.
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Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Mindfulness Programs for Young Breast Cancer Survivors
The purpose of this study is to help young breast cancer survivors who are feeling symptoms of depression. Researchers will test different ways to teach mindfulness to learn which method works best to improve mood and well-being. The programs may be done online, through an app, or with guided meditation. This study is for volunteers who had breast cancer and finished treatment, are feeling symptoms of depression, and were aged 18 to 50 when diagnosed.
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Using Ide-Cel to Treat Multiple Myeloma
The purpose of this research is to see if idecabtagene vicleucel (ide-cel) is safe and useful to treat participants with multiple myeloma.
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Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
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A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
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A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
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Testing the Study Drug Bromocriptine for New Moms with Heart Problems
Peripartum cardiomyopathy is when your heart gets weak and big during or after pregnancy. This makes it hard for your heart to pump blood like it should. The study is testing a drug called bromocriptine to help women with this problem.
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