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Learning More About Using Ivonescimab to Treat Lung Cancer
The purpose of this research study is to see if the study drug, ivonescimab, is safe and useful to treat people with a type of cancer called metastatic squamous non-small cell lung cancer.
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Testing a New Drug Combination for Patients with Myelofibrosis
The purpose of this study is to learn more about using two drugs called navtemadlin and ruxolitinib. We want to see if taking both drugs together helps treat patients with myelofibrosis. We also want to see if people can handle taking the drugs.
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Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
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Cancer Cancer: Solid Tumor Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin
Studying the Drug AZD7798 for Patients with Crohn's Disease
We are doing this study to find out if the study drug AZD7798 works well and is safe for treating Crohn's disease. We also want to learn more about Crohn's disease and the health problems it causes. AZD7798 targets a specific type of immune cell that we think might be causing inflammation in the gut for people with Crohn's disease.
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Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
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Studying a New Cell Therapy for Patients with Newly Diagnosed Multiple Myeloma
The purpose of this study is to learn more about a cell therapy called Cilta-cel. This type of treatment changes the white blood cells to help treat multiple myeloma. We want to see if this type of treatment works better than the usual treatment for patients with Multiple Myeloma.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Using the Study Drugs Atezolizumab and Bevacizumab to Treat Liver Cancer
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Studying the Drug STX-721 for Patients with Advanced Non-Small Cell Lung Cancer
The purpose of this study is to learn more about the study drug STX-72. We want to see if the study drug is safe and helpful for treating people with advanced non-small cell lung cancer. Volunteers must have a specific gene change related to EGFR or HER2.
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Studying a New Medicine to Treat Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy is a disease that makes the heart muscle too thick which can make it harder for the heart to pump blood. The purpose of this study is to learn more about a new medicine for this disease called EDG-7500. We want to see if this medicine is safe and useful to treat patients.
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Studying Ways to Lower Blood Pressure and Prevent Another Stroke
Stroke survivors are at high risk of having another stroke; one in four will have another stroke. Hypertension is a leading cause of stroke. The purpose of this study is to help patients who have had a stroke to control and lower their blood pressure to prevent another stroke. We will compare two ways to do this: clinic visits with health education and personalized telehealth care. This study will help us find out which method works best for different patients. We are looking for volunteers who have had a stroke and have been discharged home from acute care or acute inpatient rehabilitation facility.
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Studying a New Treatment for Virus After Transplant
Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV/PTLD) is a virus that can happen after receiving a solid organ transplant or allogenic cell transplant. The purpose of this study is to learn more about a new treatment called tabelecleucel. We want to see how well this treatment works for patients with this virus who did not get better with a treatment called rituximab or rituximab plus chemotherapy.
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Using MRI to Protect the Brain in Lung Cancer Patients
This study is about finding out if using brain scans alone, instead of brain scans plus preventive brain radiation, affects how long people with small cell lung cancer live.
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Understanding Sleep Patterns Among Children and Young Adults with Cancer
The purpose of this study is to learn more about how sleep changes in children and young adults during and after cancer treatment. Our researchers want to understand when sleep problems start and how to treat them. The goal is to improve sleep and overall health during cancer care. We are looking for volunteers who were recently diagnosed with cancer and plan to receive cancer therapy.
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Studying What Concerns Care Teams about Immune Therapy for Transplants
The purpose of this study is to learn what makes doctors decide if they should use a certain cancer treatment in people who have had organ transplants and serious skin cancer. We will survey patients, doctors, and ethics experts (people who help others figure out what is right or wrong when making tough decisions). If you join the study, you will be asked to take a survey about your thoughts on a certain type of cancer treatment.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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