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Studying the Medicine Dupilumab for Treating Rough, Itchy Skin
Lichen simplex chronicus (LSC), also called neurodermatitis, is a long-term skin condition that makes your skin very itchy and can cause thick, rough patches. The purpose of this study is to find out if a medicine called dupilumab can help adults who have this skin problem. Our researchers want to see if the medicine can make the itching better, help people sleep better, and improve how they feel about their health and daily life.
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Studying the Medicine Triptorelin to Protect Ovaries During Chemotherapy
The purpose of this study is to learn more about a medicine called triptorelin. We want to find out if it can help protect the ovaries of teens and young adults during cancer treatment. Some cancer drugs can damage the ovaries and make it harder to have children later in life. Our researchers are studying this medicine to see if it works better than the usual methods used to protect the ovaries. We are looking for women volunteers with cancer who are receiving a specific type of chemotherapy called an alkylating agent.
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Understanding How Breast Size Affects Migraine Headaches
The purpose of this study is to find out if breast tissue affects headache and neck pain. Some studies show that having large breasts might be linked to pain in the head and neck, but we do not fully understand the reasons for this. In this study, we will monitor how headache features change before and after plastic surgery. We are looking for volunteers who are seeing Plastic Surgery for breast reduction (reduction mammoplasty) or excess skin removal (panniculectomy) procedures.
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Studying a New Medicine to Lower Bad Cholesterol
The purpose of this study is to learn more about a new medicine called AZD0780. We want to see if this medicine can lower bad cholesterol and help prevent heart attacks or strokes. This study is for volunteers with heart disease or who are at high risk of heart problems. The goal is to see if the new medicine works better than current treatments and is safe for patients.
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Studying the Drug VX-670 for Adults with Myotonic Dystrophy Type 1
The purpose of this study is to learn more about the study drug VX-670. We want to find out if it is safe and if adults with myotonic dystrophy type 1 can handle it well.
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Comparing Two COVID-19 Vaccines in Healthy Adults
The purpose of this study is to compare two trial COVID-19 vaccines. We want to see if they are safe and if they help prevent COVID-19 in healthy adults aged 50 to 64. Volunteers in the study will get either one of the trial vaccines or a placebo (a shot with no vaccine). We will compare how well the vaccines work and check for any side effects.
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Healthy Volunteers Infectious Diseases Screening and Prevention
Testing a New Formula of Cladribine for Patients with Generalized Myasthenia Gravis
Generalized myasthenia gravis is a condition where the body's defense system attacks the muscles, making them weak and tired. The purpose of this study is to find out how well a new medicine called Cladribine works compared to a fake medicine. We also want to see how well patients can handle the new medicine.
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Testing Two Different Ways to Help Unblock Stomachs
The purpose of this study is to compare two different treatments to help people with blocked stomachs, usually because of cancer. We want to see which treatment works better and can lower the chance of symptoms like pain, nausea or vomiting from coming back.
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Stomach and Intestines Cancer Cancer: Stomach and Intestines
Stem Cell Transplant After Chemotherapy for Lymphoma Patients
The purpose of this study is to find out if giving a stem cell transplant after chemotherapy helps people with Peripheral T-cell Lymphoma stay healthy longer. Doctors will compare people who get the transplant to people who do not. The goal is to see which way works better to keep the cancer from coming back.
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Studying the Medicine Belimumab for Adults with Lupus
The purpose of this study is to learn more about the medicine belimumab for adults who were recently diagnosed with lupus. We want to see if the medicine can make symptoms better and reduce the need for other medicines that may cause problems over time. We will also will check the safety of this medicine when used for three years.
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Studying the Medicine Pelacarsen for Heart Disease and Cholesterol
The purpose of this study is to learn more about the medicine pelacarsen. We want to see if this medicine is safe and can help people with heart disease and high cholesterol. Our researchers will compare pelacarsen to a placebo to see if it lowers a type of cholesterol called lipoprotein(a). The goal is to learn if this medicine can help prevent heart problems in the future.
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CARES Study: Listening to Caregivers
The purpose of this study is to learn more about the health of caregivers. We want to understand how life experiences before and during caregiving for someone with dementia may impact physical and emotional health over time. The goal is to find better ways to help caregivers feel supported. This study is done completely over the phone. Volunteers will get one call for an interview and then a follow-up call to connect them to resources, if needed.
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Studying the Medicine Usnoflast for ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly damages the nerves that control muscles, making it hard to move, speak, eat, and breathe. The purpose of this study is to learn more about a new medicine called usnoflast for this disease. Our researchers want to see if the medicine can safely help slow down the disease and improve how people feel and live.
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Movement Disorder Neurology Disorders Bones, Joints, Muscles Brain and Memory
Studying Plixorafenib for Cancers with BRAF Gene Changes
The purpose of this study is to learn more about the medicine plixorafenib. We want to see if this medicine can help people whose cancer has a change in the BRAF gene. The medicine is being studied to see if it works and if it is safe. People in the study will take the medicine and be watched closely for any changes or side effects.
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Learning How E-Cigarettes Affect Brain Health Over Time
The purpose of this study is to find out how using e-cigarettes for a long time affects the brain. We will compare people who switched to e-cigarettes with people who quit all tobacco and nicotine. The goal is to learn if switching to e-cigarettes helps the brain as much as quitting smoking.
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Substance Use (Alcohol, Illegal Drugs, Tobacco) Brain and Memory
Studying a New Medicine to Help People with Type 2 Diabetes Lose Weight
The purpose of this study is to see if a new medicine can help people with type 2 diabetes who are overweight or obese lose weight safely. Our researchers will compare the new medicine to a placebo to see how well it works and if it is safe. Volunteers in the study will get regular check-ups and tests to make sure they stay healthy.
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Things that May Predict Memory Decline or Dementia in Adults (Healthy Brain Study)
This study is being done to look at changes in memory, thinking and brain structure in older adults. We will also study how the body processes sugar and how that may relate to change in brain function over time.
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A Study of the Drug Reparixin for Patients with Myelofibrosis
The purpose of this study is to learn more about the study drug Reparixin. This study drug is for people with a type of blood cancer called myelofibrosis. We want to find out if Reparixin is safe and if it helps treat this cancer.
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Exploring a New Program to Care for Rural Patients with Chronic Pain
The purpose of this study is to test a new program for patients in rural areas with chronic pain. We want to see if this program can help patients better manage their pain and daily functioning by working with a nurse care manager.
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