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How Salt Affects Blood Pressure in Young Adults Who Were Born Prematurely
The purpose of this study is to learn about how salt in the diet affects blood pressure in young adults who were born prematurely. We also want to find out if the medication, allopurinol, can change how salt in the diet affects blood pressure.
Study Topics
Healthy Volunteers Heart Health Kidneys, Liver, Pancreas Children, Infants, Teen Health
Studying the Medicine MK-2870 for Breast Cancer After Surgery
The purpose of this study is to learn more about a new medicine called MK-2870. We want to see if this medicine works better than current treatments for people with triple-negative breast cancer who had surgery but still have cancer. Our researchers want to see which treatment helps people live longer and feel better. They also want to learn about side effects and how safe the new medicine is.
Study Topics
Studying the Medicine BMS-986482 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine BMS-986482. We want to see if this medicine is safe and works well for patients with certain types of cancer including non-small cell lung cancer, melanoma, colorectal cancer, breast cancer, urothelial cancer, prostate cancer, head and neck cancer or gastric cancer. We will compare this medicine alone or with other approved cancer medicines.
Study Topics
Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Head, Neck Cancer: Lung Cancer: Prostate Cancer: Skin Cancer: Stomach and Intestines Cancer: Urinary and Bladder
Learning More About Rheumatoid Arthritis Treatments
The purpose of this study is to learn more about rheumatoid arthritis. We want to learn more about rheumatoid arthritis treatments and how well they work. The information collected in this study may help improve the care of people with rheumatoid arthritis. This is not a treatment study.
Study Topics
Testing a New Study Device for Tricuspid Regurgitation
The purpose of this study is to test a study device called Edwards EVOQUE system for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
A Study of the VBX Device for Patients with Peripheral Artery Disease
The purpose of this study is to learn more about the VBX Stent Graft study device. We want to see if the study device is safe and works well for patients with complex iliac occlusive disease, a form of peripheral artery disease. We will compare this study device to another device called Bare Metal Stents and see which one will work better.
Study Topics
Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
A Study of the Drug Staccato Alprazolam for Patients with Prolonged Seizures
The purpose of this study is to learn more about the study drug Staccato Alprazolam. We want to see how well the study drug works for treating patients with previous episodes of prolonged seizures. We also want to learn more about the safety and side effects that may be caused by the study drug.
Study Topics
Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
Study Topics
A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about the study drug ABBV-525. We want to see if this study drug is safe and useful for the treatment of B-cell non-Hodgkin's Lymphoma that has returned or is not responding to current treatment. We also want to learn about the side effects that may be caused by taking this drug.
Study Topics
Studying a New Study Catheter to Treat Rapid Heartbeat
The purpose of this study is to learn more about a new study catheter. We want to see if this catheter can help treat episodes of rapid heartbeat in patients with heart problems not caused by blocked arteries or heart attacks. We want to learn more about the safety and effectiveness of this catheter.
Study Topics
Studying Medicines to Help People Breathe Better with COPD
The purpose if this study is to learn more about the medicines Budesonide, Glycopyrronium, and Formoterol Fumarate. We want to see how well the medicines work for preventing chronic obstructive pulmonary disease (COPD) flare-ups.
Study Topics
Using Upadacitinib to Treat Arthritis in Children and Young People
The purpose of this study is to learn more about treating arthritis in children and young people with the study drug, upadacitinib. We want to see if this treatment works better than the usual treatment.
Study Topics
Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Testing a Radiation-Based Treatment for Prostate Cancer that has Spread
The purpose of this study is to find out if radiation treatment with Lutetium Lu 177 Dotatate can shrink or slow the growth of prostate cancer. We want to find out if this approach is better or worse than the usual approach.
Study Topics
Using Mavacamten to Treat Adolescents with Cardiomyopathy
Obstructive Hypertrophic Cardiomyopathy (HCM) is a heart condition that makes it hard for the heart to pump blood and may make a person feel weak and tired. The purpose of this study is to see if the study drug, mavacamten, helps young people with obstructive HCM.
Study Topics
Studying a New Pneumococcal Disease Vaccine Among Healthy Toddlers
Your child is being asked to join this study because they are healthy, between 12 to 15 months old, and have had 3 doses of Prevnar 20®. The study will test a new vaccine to see if it can protect against a germ that causes infections in children. The goal is to check if the vaccine is safe and helps the body make antibodies to fight the germ.
Study Topics
Healthy Volunteers Infectious Diseases Screening and Prevention Children, Infants, Teen Health
Learning More About Blood Tests to Determine if a Cancer Patient Will Respond to Treatment
Not all patients treated with immune checkpoint inhibitors respond with tumor shrinkage. Many patients have serious side effects. The purpose of this study is to develop blood tests that can help determine if patients will respond to treatment and develop side effects.
Study Topics
Treating Uncontrolled Seizures with the Study Drug NRTX-1001
The purpose of this study is to learn more about treating uncontrolled seizures with the study drug NRTX-1001. We want to see how the study drug works and find out what side effects may be caused.
Study Topics
Testing a Study Device for Treatment of Sudden Tear in the Aorta
The purpose of this study is to find out if the study device called AMDS is safe and works well for treating this condition. We want to see if this device can help heal the aorta's walls and reduce the need for surgery.
Study Topics