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Learning More About How Sedatives Affect Tobacco Cravings and Withdrawal Symptoms
The purpose of this research is to learn more about the effects of sedative medication on the mood, behavior, and brains of smokers. We are not testing a treatment for quitting smoking. We are interested in how the medication affects tobacco craving and withdrawal symptoms. Taking part in this research will involve 5 visits and last about 5 weeks.
Study Topics
Healthy Volunteers Substance Use (Alcohol, Illegal Drugs, Tobacco)
Study to Find Out How Well Pritelivir Works for Treating Skin Lesions Caused by Herpes
In patients with an impaired immune system, herpes ulcers are usually extensive, deep and cause severe pain. The standard treatment sometimes doesn't work for these patients. The purpose of this study is to see how well the study drug, Pritelivir, may work for this group of patients. We also want to find out what side effects may be caused by the study drug.
Study Topics
Finding Out How Well Rimegepant Works for Treating Migraines in People Ages 12 to 17
The purpose of this study is to find out how well the study drug, Rimegepant, works for treating migraines in people age 12 to 17. We also want to find out how safe it is in children and young people.
Study Topics
Neurology Disorders Pain Brain and Memory Children, Infants, Teen Health
Learning More About How Patients Take Their Psoriasis Medication
The purpose of this study is to learn more about how people choose to take their psoriasis medication. We want to find out if sending daily and weekly reminders will help patients take their medication as directed. The study will also look at how well the medication works for patients who take it as directed compared to those who do not. Taking part in this study involves two office visits, taking a daily med, and an exit interview.
Study Topics
Treating Glioblastoma with the Study Drug Dichloroacetate
The purpose of the study is to find out if the study drug, Dichloroacetate, can keep glioblastomas from growing. We want to know if the study drug can help improve the health of patients with glioblastomas that have returned or been difficult to treat.
Study Topics
Learning More About Treating Childhood Absence Epilepsy and Juvenile Absence Epilepsy with Brivaracetam
The purpose of this study is to see how well the study drug, brivaracetam, treats childhood absence epilepsy or juvenile absence epilepsy. We also want to learn more about any possible side effects it may cause.
Study Topics
Learning More About Preventing Bone Loss in Older Adults that Have Lost Weight
The purpose of this study is to see if losing weight affects bone health in older adults. You will join a group to help you lose weight and may do exercises at a gym three times a week. You might also take a pill called alendronate, which helps keep bones strong, or a placebo for one year.
Study Topics
Reducing Distress and Tobacco Use in Cancer Survivors with At-Home Brain Stimulation
The purpose of this study is to find out if transcranial direct current stimulation (TDCS) is easy to use at home. We also want to find out how well it works for reducing distress and decreasing cigarette use. TDCS is a form of brain stimulation. This type of stimulation is done outside of the body. The largest risk with this study is minor discomfort such as warmth, itching or tingling sensation during treatment.
Study Topics
Mental Health Substance Use (Alcohol, Illegal Drugs, Tobacco) Cancer
How Myotonic Dystrophy Type 2 Affects the Brain
Myotonic dystrophy affects the muscles and other body systems. The purpose of this study is to look at the impact myotonic dystrophy type 2 has on the brain. We also want to look at brain-based symptoms like problems with thinking, memory or motivation.
Study Topics
Finding Therapies that Improve Survival for Patients with Glioblastomas
The purpose of this research is to test multiple study treatments for glioblastoma. We want to find out if any of these study treatments can improve how long patients live.
Study Topics
Learning More About the NeuroBlate System to Treat Cancer that Has Spread to the Brain
The purpose of this study is to better understand how well the NeuroBlate System works for treating brain metastases. The system will be used along with laser interstitial thermal therapy (LITT). The NeuroBlate System uses laser light energy to heat and destroy the tumor. The LITT procedure includes a biopsy of brain tissue. The procedures are considered to be minimally invasive.
Study Topics
Treating Relapsing Multiple Sclerosis with BIIB091
The purpose of this study is to find out how well a new drug called BIIB091 works for treating relapsing multiple sclerosis. We also want to find out how well the body can handle taking the study drug.
Study Topics
Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
Study Topics
High Blood Pressure in Children and Teenagers
The purpose of this study is to understand what causes high blood pressure in young people. We also want to learn more about how high blood pressure can cause damage to the heart and kidneys.
Study Topics
Healthy Volunteers Heart Health Children, Infants, Teen Health
Can Immunotherapy Help Non-Small Cell Lung Cancer Patients Improve Physical Function
The purpose of this study is to see if treatment with immunotherapy can help lung cancer patients who get tired easily and struggle with some daily tasks.
Study Topics
Is it More Helpful to Give Children with Germ Cell Tumors Chemotherapy on a Faster Schedule
A germ cell tumor is a type of cancer found in the ovaries for females or the testes for males. This tumor may also be found in the pelvis along the tailbone, chest, abdomen, and other structures of the body. Chemotherapy is the medicine used to fight cancer. We want to find out if giving children with germ cell tumors chemotherapy on a faster schedule is effective.
Study Topics
A study on the Effectiveness of Four Drugs (Vismodegib, GSK2256098, capivasertib, abemaciclib) Against Meningioma Tumors
The purpose of this study is to see if tumor genetic testing would be helpful when selecting a treatment for meningioma. The usual treatment for meningioma is the same for all patients and not based on tumor genetic testing. This study will look at the tissue of your tumor to see what types of mutations it has across different types of genes. Study treatment will be based on the type of altered genes in your tumor.
Study Topics
How the Brain Processes Information
The purpose of this study is to look at how the human brain processes information. We want to know how the human brain responds to different stimuli, how those stimuli make you feel, and how your feelings guide your decisions.
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Combination Chemotherapy for Newly Diagnosed and Relapsed Wilms Tumor
The purpose of this study is to find out if we can improve treatment for those with Wilms tumors. We will be testing three different combinations of radiation and chemotherapy. The combination you receive will depend on your type of Wilms tumor.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Children, Infants, Teen Health