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Studying a New Pneumococcal Disease Vaccine Among Healthy Toddlers
Your child is being asked to join this study because they are healthy, between 12 to 15 months old, and have had 3 doses of Prevnar 20®. The study will test a new vaccine to see if it can protect against a germ that causes infections in children. The goal is to check if the vaccine is safe and helps the body make antibodies to fight the germ.
Study Topics
Healthy Volunteers Infectious Diseases Screening and Prevention Children, Infants, Teen Health
Testing a Study Device for Treatment of Sudden Tear in the Aorta
The purpose of this study is to find out if the study device called AMDS is safe and works well for treating this condition. We want to see if this device can help heal the aorta's walls and reduce the need for surgery.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
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A Study of the Drug AAV2-hAQP1 for Treating Dry Mouth Among Head and Neck Cancer Patients
The purpose of this study is to learn more about the study drug called AAV2-hAQP1. We want to see if this study drug can help people who have dry mouth because of radiation treatment for head and neck cancer. We want to check if this study drug will increase saliva and see if it is safe and easy for people to use.
Study Topics
Testing the Study Drug RGX-314 for Patients with Vision Loss
The purpose of this study is to learn more about the drug RGX-314. We want to see if this drug helps people with an eye disease called neovascular age-related macular degeneration. We also want to see if this drug can make their vision better or keep it from getting worse.
Study Topics
Testing a Study Device for Chronic Venous Insufficiency
Chronic venous insufficiency happens when blood gets stuck in the veins of the legs because the valves do not work right. This study wants to see if the study device Venclose™ digiRF™ Generator and its catheters are safe and good at treating this problem. We want to know if these devices can help fix the veins in the legs and stop them from leaking. The study will also check if the devices are safe to use.
Study Topics
A Study of the Drug Deucravacitinib for Patients with Lupus
The purpose of this study is to learn more about the study drug Deucravacitinib. We want to see how well the study drug works for treating Lupus. We also want to learn more about the side effects that may be caused by the study drug.
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Learning More About Brain Health and Alzheimer's Disease
The purpose of this study is to learn more about brain health and the full spectrum of Alzheimer's disease from its earliest stages. This is an observational research study, which means it has no study drug or treatment.
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Finding out if Antiviral Medicine Worked for Babies or Toddlers with Cytomegalovirus Infection
The purpose of this study is to learn more about the treatment with antiviral medicine for babies born with cytomegalovirus. We want to see if antiviral medicine has any impact on hearing, cancer risk, overall growth, or sexual development.
Study Topics
Infectious Diseases Children, Infants, Teen Health Ears, Nose, Throat, Mouth
Testing a New Device for Treatment of Urine Leakage
The INTIBIA Tibial Nerve Stimulator is a medical device. The purpose of this study is to find out how well the device treats urge urinary incontinence (UUI). UUI makes it hard for someone to hold urine which causes urine leakage.
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Comparing MitraClip and Surgery for Mitral Valve Repair
The purpose of this study is to test a study device called the MitraClipTM Device for patients with this condition and who are at moderate risk of surgery.
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How Damage to Blood Vessels in the Brain May Be Related to Thinking and Memory Problems Like Dementia
This study is being done to better understand how damaged blood vessels affect your thinking. This is not a treatment study.
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Using the GORE® Device to Treat Heart Lesions
Aortic disease may cause wounds in the blood vessels near the heart. We want to learn more about the safety and how well the study device, GORE® Ascending Stent Graft, treats these wounds.
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Taking Dasatinib and Quercetin Together to Help Slow the Progression of Alzheimer's (SToMP-AD Study)
The purpose of this study is to see how well a combination of meds may treat early Alzheimer's disease. The meds dasatinib and quercetin will be taken together.
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Learning More About Speech Profiles after a Stroke
The purpose of this study is to learn more about speech profiles among stroke survivors and healthy volunteers. Understanding more about speech profiles can help customize treatment.
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Finding the Best Timing for Surgery and Rehab for a Multiple Ligament Knee Injury
The purpose of this study is to find out if it's best to have surgery shortly after injury or wait. We also want to know if it is best to begin weight bearing and range of motion shortly after surgery or wait a few weeks.
Study Topics
Collecting Data for Parkinson's Disease Research
The purpose of this study is to gather information on people with Parkinson's disease through a patient registry. The registry will collect genetic information from people with Parkinson's, those at risk, and others without the disease. The registry will help improve understanding and care for Parkinson's disease.
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Study the Drug SNDX-5613 for Patients with Leukemia
The purpose of this study is to learn more about a drug called SNDX-5613. We want to see if this drug is safe and helpful when used with chemotherapy for people with a type of blood cancer called acute myeloid leukemia. We are looking for volunteers who are newly diagnosed and have not been treated before.
Study Topics