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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
Study Topics
Testing a New Study Device for Mitral Valve Regurgitation
The purpose of this study is to test a study device called the CardioMech Mitral Valve Repair System for patients with this condition. We want to learn about the safety and effectiveness of this device.
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Studying a New Cell Therapy for Patients with Newly Diagnosed Multiple Myeloma
The purpose of this study is to learn more about a cell therapy called Cilta-cel. This type of treatment changes the white blood cells to help treat multiple myeloma. We want to see if this type of treatment works better than the usual treatment for patients with Multiple Myeloma.
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Using the Study Drugs Atezolizumab and Bevacizumab to Treat Liver Cancer
The study wants to learn more about a drug called Atezolizumab. We want to see how well it treats liver cancer by itself and when used with another drug called Bevacizumab. We also want to know if these treatments are better or worse than the usual treatment. Volunteers must have advanced liver cancer that can't be removed by surgery.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Testing Study Drugs for Advanced Solid Tumors
The purpose of this study is to learn more about study drugs to help treat patients with advanced solid tumors. The study drugs being tested are GSK4381562, dostarlimab and belrestotug. We will try different combinations of these drugs to see if they are safe and work well.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Using CTX001 to Treat Severe Sickle Cell Disease in Children
The purpose of this study is to learn more about using the study drug, CTX001, to treat sickle cell disease in children. We want to see how effective it is and if there are any side effects.
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Collecting Data on Patients with Cystic Fibrosis
The purpose of this study is to gather information on people with cystic fibrosis through a patient registry. The patient registry helps track important changes in people with cystic fibrosis. It also helps doctors understand the disease better, improve treatments, and help patients live longer.
Study Topics
Genetic Disorders Lung Health Children, Infants, Teen Health
Testing a New Study Device for Patients with Heart Failure
The purpose of this study is to test a new study device called the CCM-D System. We want to see if this device is safe and effective for patients with heart failure and a heart that is not pumping out as much blood as it should with each beat.
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Comparing Different Medication Combinations for Brain Artery Narrowing
The purpose of this study is to see how well the combination of study drugs, ticagrelor and aspirin or rivaroxaban and aspirin, help people who have had a stroke from narrowed brain artery. We want to see if the study drugs are better than the usual treatment in preventing another stroke or death.
Study Topics
Collecting Data on Patients with Generalized Myasthenia Gravis
General Myasthenia Gravis is a rare disease that makes it hard for nerves and muscles to work together. This study collects information about people with this disease in a patient registry. The registry helps scientists learn new things that might help others in the future.
Study Topics
Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
Testing a Device to Prevent Stroke in Patients with Patent Foramen Ovale
The purpose of this study is to test a new study device called the GORE CARDIOFORM Septal Occluder. We want to see if this device can help patients with this heart condition by closing the hole in the heart and preventing another stroke.
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Comparing Treatments in Children Newly Diagnosed with Crohn's Disease
The purpose of this study is to learn more about why some children with Crohn's disease heal their bowel inflammation after one type of treatment and why others do not. Volunteers must have suspected Crohn's disease.
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Testing Ways to Find People for Blood Cancer Screening
The purpose of this study is to test recruitment methods to find and sign up people for a blood screening study. The results will help us decide if we can do a bigger study later. You are invited to join because you are Black and/or African American, live in Charlotte, NC or nearby, and are at least 30 years old. This study will also check how many people have a blood condition that might lead to blood cancer.
Study Topics
Minority Health Screening and Prevention Cancer Cancer: Blood
Studying the Drug Ipatasertib for Patients with Head and Neck Cancer
The purpose of this study is to learn more about the study drug Ipatasertib. We want to see if this study drug can be combined with chemotherapy and radiation for people with advanced head and neck cancer. The goal is to find the best dose of the drug and see if it is safe and useful.
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Testing a New Heart Valve for Mitral Regurgitation
The purpose of this study is to test a new device called the AltaValve System. We want to see if it can help treat leaky heart valves. We want to find out if the device is safe and works well for people who cannot have open-heart surgery. The study is for adults with mitral valve regurgitation.
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