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Helping Those with Serious Mental Illness Stop Smoking
People who smoke and have serious mental illness are 2-8 times more likely to fail standard stop smoking treatments. The purpose of this study is to look at ways to help this population in their efforts to quit smoking. The study tests two different cost-effective methods designed to help those with serious mental illness quit smoking. This study will be done completely online.
Study Topics
Mental Health Substance Use (Alcohol, Illegal Drugs, Tobacco)
Quality of Life Among Teens and Young Adults with Cancer
The purpose of this study is to find out more about the unique quality of life concerns in teenagers and young adults with cancer. We want to develop and test ways to measure these quality of life concerns. This information will help improve care for young cancer patients.
Study Topics
Treating Recurrent Urethral Stricture with Tissue Engineered Urethral Construct
The urethra is a thin tube-like structure that allows urine to leave your bladder. Urethral stricture is a narrowing of the urethra that affects the flow of urine out of your bladder. The purpose of this study is to find out if an engineered urethra made from your own cells can be surgically implanted safely. We also want to find out if the implanted urethra helps improve urinating. The new urethral segment will be created using cells from your bladder, which are the same cells that make up your urethra.
Study Topics
Learning More about the Study Drug Lepodisiran to Reduce Heart Attacks and Stroke
The purpose of this study is to learn more about the study drug lepodisiran. We want to see if the study drug can reduce problems like heart attack or stroke in adults with elevated lipoprotein (a). We also want to learn more about the side effects that may be caused by the study drug.
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Study of the Drug Rituximab With and Without Stem Cell Transplant for Treating Mantel Cell Lymphoma
The purpose of this study is to find out if an autotransplant improves survival for mantle cell lymphoma patients who have achieved first complete remission. An autotransplant is a procedure in which a high dose of chemotherapy is given followed by stem cell infusion.
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Studying Ways to Improve Physical Activity in Young Adult Cancer Survivors
The purpose of this study to test four different ways to improve physical activity in young adult cancer survivors. We want to learn more about each approach and see which one will work best.
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Combination Chemotherapy for Newly Diagnosed and Relapsed Wilms Tumor
The purpose of this study is to find out if we can improve treatment for those with Wilms tumors. We will be testing three different combinations of radiation and chemotherapy. The combination you receive will depend on your type of Wilms tumor.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Children, Infants, Teen Health
Testing an Online Weight Management Program for Adults with Type 2 Diabetes (VITAL-CGM)
The purpose of this study is to test the effects of an online weight management program. Volunteers will use a weight management app on their phone. They will attend weekly workshops and weekly check-ins online using Zoom. Volunteers will also wear a continuous glucose monitor during the study. The glucose monitor will be linked to the app. Please copy and paste the following link into your web browser to complete a survey to see if you might qualify for this study. https://redcap.link/ky775p24
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Head Trauma Among Student Athletes
We want to learn about how head movement during a contact sport-related hit to the head affects the brain. Contact sports include those which may involve contact to the head during play such as football and soccer.
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Healthy Volunteers Brain and Memory Children, Infants, Teen Health
Study Identifying Genetic Markers of Ovarian Cancer
The purpose of this study is to learn more about biological markers found in tissue, blood, and fluids. These markers may be able to tell us how severe a cancer can be and how well a cancer is responding to treatment.
Study Topics
Testing AURN001 Injection for Treatment of Corneal Endothelial Dysfunction
The purpose of this study is to test a possible new treatment for polycythemia vera. The study drug is called ISIS 702843. We want to find out how well the study drug works and if there are side effects when using it.
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Learning More About the Study Drug GP-2250 for Treating Advanced Pancreatic Adenocarcinoma
The purpose of this study is to find out how the study drug GP-2250 may affect advanced pancreatic cancer. The study drug will be given along with the usual treatment Gemcitabine. We want to see if this combination works better than the usual approach. We also want to learn more about possible side effects.
Study Topics
I-SPY 2 TRIAL: Study of New Drugs to Treat Breast Cancer Before Surgery
The purpose of this study is to learn more about giving the best treatment at the right time. Treatment on this study will be given before surgery. This allows us to better understand how different people's breast cancers respond to commonly used chemotherapy with or without new drugs.
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Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
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Internet-Based Program to Help Cancer Survivors Manage Pain
The purpose of this study is to learn more about an internet-based pain program combined with pain education. We want to see if the pain program and education can help reduce pain and improve impact on daily activities. We also want to see if this approach is better or worse than the usual approach.
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Testing a New Treatment for Myeloproliferative Disorders
The purpose of this study is to see how well the study drug, INCA033989, works for treating myeloproliferative disorders. We want to find what effects, if any, this therapy may have on people. We also want to find out what is the highest dose that can be given without causing severe side effects.
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Creating a Database of People with Huntington's Disease
This study is being done to create a database of information from patients with a history of Huntington's disease. This information will be used to try and find new treatments for the disease.
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Study to Find Out if the Study Drug, Memantine, Can Help with Learning, Remembering and Problem Solving After Treatment with Radiation Therapy to the Brain
The goal of this study is to find out if the study drug, memantine, can prevent or decrease a worsening in cognitive function. Cognitive function includes tasks like learning, remembering and solving problems. Those tasks can be affected by radiation to the brain.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens
A Registry for People taking Humira for Ulcerative Colitis
The purpose of this study is to collect long-term data on people taking Humira for ulcerative colitis. This registry only involves the collection and storage of data. There are no procedures or treatments required. There are no additional risks associated with this collection of data.
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