Search Studies
Testing the Study Drug Olvi-Vec for Ovarian Cancer that Resists Treatment
The purpose of this study is to learn about the drug Olvi-Vec. We want to see if it is safe and helpful for treating ovarian, fallopian tube, or peritoneal cancer that did not get better with a type of treatment called platinum-based chemotherapy.
Study Topics
Studying Treatment Options for Multiple Myeloma After a Stem Cell Transplant
The purpose of this study is to find out which treatment works best to keep multiple myeloma from coming back after a stem cell transplant. Our researchers will compare three options: a new medicine called teclistamab with standard treatment called lenalidomide, lenalidomide alone, or teclistamab alone. The goal is to see which treatment helps people stay healthy longer.
Study Topics
Studying a New Medicine for Generalized Myasthenia Gravis
Acetylcholine receptor antibody positive generalized myasthenia gravis (AChR+ gMG) is a disease where the body's immune system attacks the places where nerves talk to muscles, making the muscles weak and tired. The purpose of the study is to learn more about a new medicine and see how well it helps people in their everyday activities.
Study Topics
Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
Helping Improve Breast Cancer Care for Young Women
The purpose of this study is to learn more about breast cancer in younger women and help improve care in the future. Women who were diagnosed with breast cancer between the ages of 18 and 45 can agree to submit blood, tissue, and/or stool samples. Not all samples are required, and samples can be submitted from pre-existing tissue (ie biopsy). Researchers will evaluate the samples to look for patterns and differences to help guide future research and treatment.
Study Topics
Collecting Samples to Learn About Childhood Cancer
The purpose of this study is to find better treatments in the future for children with cancer. We want to create a large collection of blood and tissue samples from children cancer to help doctors learn more about how cancer and the immune system work together. Information from this study may help us find better ways to treat cancer in the future. We are looking for volunteers who have been diagnosed with any type of pediatric cancer and are under the care of a doctor at Atrium Health.
Study Topics
Using NK Cells to Treat Sarcoma
The purpose of this study is to see if adding a special type of immune cell called "natural killer" (NK) cells to chemotherapy can help treat cancer better. NK cells are good at finding and killing cancer cells.
Study Topics
Cancer Cancer: Children, Teens Cancer: Sarcoma (Bone, Muscle, Soft Tissue)
Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Mindfulness Programs for Young Breast Cancer Survivors
The purpose of this study is to help young breast cancer survivors who are feeling symptoms of depression. Researchers will test different ways to teach mindfulness to learn which method works best to improve mood and well-being. The programs may be done online, through an app, or with guided meditation. This study is for volunteers who had breast cancer and finished treatment, are feeling symptoms of depression, and were aged 18 to 50 when diagnosed.
Study Topics
A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
Study Topics
A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
Study Topics
Testing the Study Drug Bromocriptine for New Moms with Heart Problems
Peripartum cardiomyopathy is when your heart gets weak and big during or after pregnancy. This makes it hard for your heart to pump blood like it should. The study is testing a drug called bromocriptine to help women with this problem.
Study Topics
Studying ADU-1805 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine ADU-1805 when given with the cancer medicine pembrolizumab (Keytruda). We want to see if it is safe and can help treat advanced solid tumors. We will also look at how the body responds to and processed the study treatment. This study is for volunteers diagnosed with an advanced solid tumor, such as colorectal cancer, endometrial cancer, kidney cancer, or non-small cell lung cancer.
Study Topics
Studying the Medicine Depemokimab for COPD
The purpose of this study is to learn more about the medicine depemokimab. We want to see if this medicine can help people with COPD feel better. Volunteers in the study will get either the new medicine or a placebo and will be watched closely for changes in their health. The goal is to see if the medicine works and is safe for people with COPD.
Study Topics
Finding Out How Well Selinexor Works for Treating Brain Cancer
The purpose of this study is to find the safest dose of the study drug, Selinexor. We also want to find out if adding the study drug is better than the usual treatment for brain cancer.
Study Topics
Studying Two Ways to Treat Stomach Cancer
The purpose of this study is to learn more about different ways to treat stomach cancer. Our researchers want to see if giving a cancer medicine called paclitaxel directly into the belly, along with regular chemotherapy, can help lower the chance of stomach cancer growing or spreading. We will compare this new treatment to the usual care most people get for stomach cancer.
Study Topics
Studying CAR T-Cell Therapy for Aggressive B-Cell Lymphoma
The purpose of this research is to find new ways to treat lymphomas that have come back or stopped responding to treatment. Researchers will study a new cell therapy made from a person's own immune cells for aggressive B‑cell lymphoma. The study looks at how safe this treatment is and how well it helps shrink or control the cancer.
Study Topics
Understanding Pregnancy Goals During Weight-Loss Treatment
The purpose of this study is to learn about pregnancy goals among women receiving obesity treatment. Our researchers will use this information to improve care and planning for future pregnancies after obesity treatment. This study is for volunteers who are undergoing obesity treatment and may become pregnant in the future.
Study Topics
Using a Small Device to Track Muscle Changes in ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly makes muscles weaker and harder to control, making it tough to walk, talk, or breathe. The purpose of this study is to see how a small device called the mScan can measure muscle changes in people with ALS. The device uses a tiny, painless electrical signal to check muscles. Our researchers hope this will help track ALS over time and see how well treatments work.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Studying a New Medicine for Severe Heart Failure
The purpose of this study is to find out if a new medicine called omecamtiv mecarbil can help people with serious heart failure. The medicine may help the heart pump better and lower the chance of problems like hospital visits or other serious health issues. We hope this research will help doctors treat heart failure in the future.
Study Topics
Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
Study Topics