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Studying Inobrodib for Multiple Myeloma
The purpose of this study is to learn more about a medicine called inobrodib. Our researchers will study this medicine along with two other medicines among people with multiple myeloma. The study will look at how safe this treatment is and how well it works when other treatments have stopped working.
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Studying Chemo Before Surgery for Abdominal Sarcoma
The purpose of this study is to learn more about giving chemotherapy before surgery for a type of cancer called retroperitoneal sarcoma. We want to see if this helps lower the chance of the cancer coming back. We will compare two groups: one that gets surgery only and one that gets chemotherapy first and then surgery. This will help doctors learn which treatment works better in the future.
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Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
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Studying a New Medicine for Muscle Weakness Diseases
The purpose of this study is to see if a new medicine called anifrolumab helps people with muscle weakness diseases called polymyositis and dermatomyositis. The medicine will be given as a shot under the skin, along with regular treatment. The study will check if this medicine helps people feel better and need less of their usual medicine.
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Movement Disorder Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
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Studying the Medicine Olutasidenib for AML After Venetoclax
The purpose of this study is to learn more about the medicine olutasidenib. Researchers want to see if this medicine can help adults with a type of blood cancer called acute myeloid leukemia (AML) that has come back or has not improved after treatment with venetoclax.
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Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
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Preventing Chickenpox Among Children
The purpose of this study is to learn more about a new chickenpox vaccine for young children. Chickenpox, also called varicella, is common in children and can cause fever, itchy rashes, and serious infections. Doctors have safely used chickenpox vaccines in children for many years, but there is currently only one option available. This study will help researchers see how well a new vaccine works compared to the one already in use.
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Healthy Volunteers Screening and Prevention Children, Infants, Teen Health
Understanding Seizures Using a Small Brain Monitoring Device
The purpose of this study is to find better ways to diagnose and treat epilepsy when regular tests do not give clear answers. Epilepsy is a brain condition that can cause seizures and affects many people. This study will test a small device surgically placed under the scalp that tracks brain activity all the time to see if it can give more accurate information about seizures.
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Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Studying Axatilimab for Children and Teens with Chronic Graft‑Versus‑Host Disease
Chronic graft‑versus‑host disease (GVHD) is a condition where donated stem cells attack the patient's body after a transplant, causing ongoing health problems. The purpose of this study is to learn more about the medicine axatilimab for children and teens with this condition. The goal is to see if this treatment works better and is safe compared to other medicines already used.
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Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Studying a New Medicine for Juvenile Psoriatic Arthritis
Juvenile psoriatic arthritis is a disease in kids and teens that causes joint pain and swelling along with skin problems like red, scaly patches. The purpose of this study is to learn more about the medicine secukinumab for this disease. We will check if the medicine is safe and how the body handles it.
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Arthritis, Lupus, and Autoimmune Disorders Children, Infants, Teen Health
Studying a New Treatment for Multiple Sclerosis (MS)
The purpose of this study is to test a new medicine called remibrutinib to see if it can help slow down secondary progressive multiple sclerosis (SPMS). Participants will receive either the study medicine or a placebo (a pill with no active medicine) during the first part of the study. Researchers hope this study will help find new treatment options for people living with SPMS.
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Testing New Cholesterol Medicine After Heart or Leg Procedures
The purpose of this study is to look at whether a medication called inclisiran can help prevent serious heart and blood vessel problems in people who recently had a procedure to open blocked arteries in their heart or legs. Researchers want to learn if inclisiran, when added to regular care, can lower the chance of future heart attacks, strokes, repeat artery procedures, or serious circulation problems in the legs.
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Testing Treatment Before Surgery for Advanced Head and Neck Cancer
This study is testing whether giving chemotherapy or chemo-immunotherapy before surgery works better than surgery alone for advanced head and neck cancer. Researchers want to learn if this approach can help more people stay cancer-free after treatment.
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Studying a New Treatment for Advanced Solid Tumor Cancers
The purpose of this study is to learn more about a new cancer treatment called GTAEXS617. Researchers want to find a safe dose, learn about its side effects, and see if it helps treat advanced solid tumors when used alone or with other cancer treatments.
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Studying the Medicine BMX-001 to Reduce Mouth Sores in Head and Neck Cancer
The purpose of this study is to learn more about the medicine BMX-00. We want to see if adding this medicine to usual chemotherapy and radiation can help lower the chance or severity of mouth sores and pain in people with head and neck cancer. People in the study will get either BMX-001 or a placebo, along with their regular treatment. The goal is to see if BMX-001 works better than the usual care for these side effects.
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Studying a New Medicine for Advanced Bladder Cancer
The purpose of this study is to learn more about the medicine called Disitamab Vedotin. We want to see if this medicine helps people with advanced bladder cancer that has a certain protein called HER2. We will check if the medicine can shrink or slow down the cancer and if it is safe for patients. Doctors will also look at how the treatment affects how people feel and their quality of life.
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Studying Two New Treatments for Advanced Prostate Cancer
The purpose of this study is to learn more about two new medicines used together in people with advanced prostate cancer. Researchers want to find the safest dose, better understand possible side effects, and learn how well the treatment may help fight cancer. This study is for adults who have been diagnosed with advanced prostate cancer.
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Testing a New Heart Valve for Severe Aortic Valve Disease
The purpose of this study is to test a new heart valve called Siegel THV. Researchers want to learn how safe it is and how well it works for people with severe aortic stenosis. They will follow participants over time to see how they do after treatment.
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Comparing Two Surgeries to Help Prevent Ovarian Cancer
The purpose of this study is to compare two surgeries for people with a BRCA1 gene change who have a higher risk of ovarian cancer. Researchers want to learn if removing only the fallopian tubes is as effective as removing both the fallopian tubes and ovaries in lowering the risk of ovarian cancer, while also looking at quality of life and menopause-related symptoms.
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