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Studying Two Medicine Combinations for Chronic Lymphocytic Leukemia
The purpose of this study is to compare the combination of sonrotoclax and zanubrutinib against the combination of venetoclax and acalabrutinib. Researchers want to learn which combination works better and is safe for treating chronic lymphocytic leukemia (CLL).
Study Topics
Helping Young Cancer Survivors Feel Better Using a Digital Tool
The purpose of this study is to learn more about a new digital tool to help adolescents and young adult cancer survivors manage their symptoms of depression. People in the study will use the tool, answer questions, and join a video call. The goal is to find out if the tool helps them manage their feelings better. All study visits and consultations will be done virtually.
Study Topics
Mental Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
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Studying New Medicine and Chemo for Rare Throat Cancer
The purpose of this study is to see if adding a new medicine called nivolumab to regular chemotherapy helps treat a rare throat cancer called nasopharyngeal carcinoma. We will also look at whether children can get less radiation and have fewer side effects. The goal is to find safer and better ways to treat this cancer.
Study Topics
Cancer Cancer: Children, Teens Cancer: Ear, Nose, Mouth, Throat
Studying Letermovir in Children and Teens After Kidney Transplant
The purpose of this study is to learn more about a medicine called letermovir among children and teens who have had a kidney transplant. Researchers want to see how the medicine works in the body and if it is safe. This will help doctors find the right dose for young patients.
Study Topics
Studying a New mRNA Medicine for Blood Cancer
The purpose of this study is to learn more about a new medicine called mRNA-2808 for people with multiple myeloma, a type of blood cancer. This medicine helps teach your immune system how to find and kill cancer cells. The goal is to see if the medicine is safe and to find the best dose. Researchers will also study how it affects the cancer and the body.
Study Topics
Studying a New Medicine for a Rare Blood Cancer - Chronic Myeloid Leukemia (CML)
The purpose of this study is to learn more about a medicine for a rare blood cancer called chronic myeloid leukemia. We want to see if the medicine TERN-701 can safely stop or slow down cancer. This study is for patients with chronic myeloid leukemia (CML) who have already tried other treatments that did not work or caused problems.
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A Study of a New Vaccine to Help Protect Babies from Serious Infections
The purpose of this study is to learn more about a new pneumococcal vaccine for babies. Pneumococcal germs can cause serious illnesses, such as lung infections, ear infections, blood infections, and meningitis. Researchers want to see how safe the new vaccine is and how well it helps protect babies against more types of these germs than the current vaccine. Babies younger than 3 months old may be able to take part in this study.
Study Topics
Allergies and Immunity Screening and Prevention Children, Infants, Teen Health
Studying New Treatments for Multiple Myeloma That Came Back
The purpose of this study is to find better ways to treat a type of cancer called multiple myeloma. We want to see if using different mixes of medicines works better than the usual treatment for people whose cancer came back or did not get better with other treatments. We also want to learn which medicines help the most, and check for any side effects to make sure the treatments are safe.
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Comparing Two Medicines for CLL and SLL Blood Cancer
The purpose of this study is to see how two different medicines work for people with a type of blood cancer called CLL or SLL. We will compare how safe the medicines are and how well they help control the cancer. Our researchers hope to find out which medicine works better for people whose cancer has already been treated.
Study Topics
Tracking the Long-Term Safety of the Medicine AGAMREE
Duchenne muscular dystrophy (DMD) is a disease that makes muscles get weaker over time. The purpose of this study is to track the long-term safety of a medicine called AGAMREE for this disease. People in the study will have yearly checkups and answer questions about their health. We are looking for volunteers who have DMD and are currently taking AGAMREE.
Study Topics
Genetic Disorders Men's Health Rare Disease Bones, Joints, Muscles Children, Infants, Teen Health
Studying a Treatment for Weight Loss in Pancreatic Cancer
The purpose of this study is to learn more about the study medicine called ponsegromab. We want to see if it can help adults with pancreatic cancer that has spread who have lost weight and strength because of their cancer. Researchers will compare ponsegromab to a placebo to see if it helps improve body weight, appetite, fatigue, and quality of life.
Study Topics
Weight, Metabolism, Nutrition Cancer Cancer: Kidney, Liver, Pancreas
Tracking Heart Disease Care in ATTR-CM Patients
Transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) is a disease where a protein builds up in the heart and makes it harder for the heart to pump blood. This study aims to learn more about this heart condition and how it is treated in real life. Researchers will collect information from medical records and patient surveys over time. This may help improve care for people with this condition in the future. This study is for volunteers with ATTR-CM who have started treatment within the last 90 days.
Study Topics
Studying the Medicine Pasritamig for Advanced Prostate Cancer
The purpose of this study is to learn more about a treatment called pasritamig for people with advanced prostate cancer. Our researchers want to learn if adding pasritamig to standard treatment works better than standard treatment alone and how safe it is for patients.
Study Topics
Comparing Two Heart Devices for Heart Failure
This study will compare two different ways to pace the heart to treat heart failure. There are two ways doctors can place a heart wire to help treat heart failure. One method places the wire on the outside of the heart's lower left chamber and is the standard treatment used today. The other method places the wire in a different area inside the heart called the left bundle branch area. Researchers want to compare these two approaches to see how well they work.
Study Topics
Studying the Medicine MK-2870 for Breast Cancer After Surgery
The purpose of this study is to learn more about a new medicine called MK-2870. We want to see if this medicine works better than current treatments for people with triple-negative breast cancer who had surgery but still have cancer. Our researchers want to see which treatment helps people live longer and feel better. They also want to learn about side effects and how safe the new medicine is.
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Studying the Medicine BMS-986482 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine BMS-986482. We want to see if this medicine is safe and works well for patients with certain types of cancer including non-small cell lung cancer, melanoma, colorectal cancer, breast cancer, urothelial cancer, prostate cancer, head and neck cancer or gastric cancer. We will compare this medicine alone or with other approved cancer medicines.
Study Topics
Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Head, Neck Cancer: Lung Cancer: Prostate Cancer: Skin Cancer: Stomach and Intestines Cancer: Urinary and Bladder
A Study of the VBX Device for Patients with Peripheral Artery Disease
The purpose of this study is to learn more about the VBX Stent Graft study device. We want to see if the study device is safe and works well for patients with complex iliac occlusive disease, a form of peripheral artery disease. We will compare this study device to another device called Bare Metal Stents and see which one will work better.
Study Topics
Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
Study Topics
A Study of the Drug Staccato Alprazolam for Patients with Prolonged Seizures
The purpose of this study is to learn more about the study drug Staccato Alprazolam. We want to see how well the study drug works for treating patients with previous episodes of prolonged seizures. We also want to learn more about the safety and side effects that may be caused by the study drug.
Study Topics