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Testing the Study Drug SGN-MesoC2 for Advanced Solid Tumors
The purpose of this study is to learn more about a new study drug called SGN-MesoC2. We want to see if this study drug is safe and helpful for people with advanced solid tumors. We are looking for volunteers with certain types of cancer that have spread or cannot be removed by surgery. These types of cancers include ovarian cancer, lung cancer, pancreatic cancer, endometrial cancer, colorectal cancer, or mesothelioma.
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Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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Testing an App for Better Sleep in Blood Cancer Patients
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
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Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
Study Topics
Testing a New Device for Treatment of Urine Leakage
The INTIBIA Tibial Nerve Stimulator is a medical device. The purpose of this study is to find out how well the device treats urge urinary incontinence (UUI). UUI makes it hard for someone to hold urine which causes urine leakage.
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Testing the Study Drug RGX-314 for Patients with Vision Loss
The purpose of this study is to learn more about the drug RGX-314. We want to see if this drug helps people with an eye disease called neovascular age-related macular degeneration. We also want to see if this drug can make their vision better or keep it from getting worse.
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How Damage to Blood Vessels in the Brain May Be Related to Thinking and Memory Problems Like Dementia
This study is being done to better understand how damaged blood vessels affect your thinking. This is not a treatment study.
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Finding the Best Timing for Surgery and Rehab for a Multiple Ligament Knee Injury
The purpose of this study is to find out if it's best to have surgery shortly after injury or wait. We also want to know if it is best to begin weight bearing and range of motion shortly after surgery or wait a few weeks.
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Study the Drug SNDX-5613 for Patients with Leukemia
The purpose of this study is to learn more about a drug called SNDX-5613. We want to see if this drug is safe and helpful when used with chemotherapy for people with a type of blood cancer called acute myeloid leukemia. We are looking for volunteers who are newly diagnosed and have not been treated before.
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Helping Toddlers Build Protection Against Infections
The purpose of this study is to learn more about a new vaccine. We want to see if it is safe and helps toddlers' bodies make antibodies to fight a germ called Streptococcus pneumoniae. This germ can cause different kinds of infections in children. The study will help researchers learn how well the vaccine works and if it causes any side effects. We are looking for volunteers who have a child between 12 to 15 months of age and have received 3 infant doses of Prevnar 20®.
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Healthy Volunteers Infectious Diseases Children, Infants, Teen Health
Learning More About How HIV and Marijuana Affect the Brain
The purpose of this study is to learn more about how HIV and marijuana affect the brain. This will help us understand how changes in the brain affect the way we think and behave.
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Healthy Volunteers HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco)
Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
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Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
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Virtual Reality Rehabilitation Method for Treating a Type of Vision Loss Called Visual Hemianopia
The purpose of this study is to see how well a new rehabilitation method works for treating visual hemianopia. Visual hemianopia is loss of half the vision in the right or left side of each eye. This rehabilitation may help restore vision.
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The Use of Muscle Fiber Fragments to Treat the Loss of Bladder Control in Women
The purpose of this study is to find out if injecting muscle fiber fragments into the bladder can treat bladder leakage in women. Taking part in this study will include seven study visits in a year.
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Studying a New Asthma Medicine for Adults
The purpose of this study is to learn more about a new medicine for patients with uncontrolled asthma. We want to see if the medicine called AZD8630 is safe and works well when used with an inhaler. Findings from this study may help other patients with asthma and other lung conditions in the future.
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Studying New Treatments for Head and Neck Cancer Patients
The goal of this study is to find out more about a new treatment for people with head and neck cancer. We want to see if using a treatment called Petosemtamab along with another treatment called pembrolizumab can help stop the cancer from growing or spreading and make patients feel better. We are looking for volunteers who have head and neck cancer that has spread to other parts of their body or has not gotten better with other treatments. The study team will give more details.
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Reducing Infection Risk in C-Section Deliveries
The goal of this study is to find a way to lower the chance of getting an infection after a C-section. We want to see if using two antibiotics instead of one before the C-section can help prevent infections like endometritis, wound infection, or sepsis. We are looking for volunteers who are at least 23 weeks pregnant and are planning to have a C-section.
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