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Comparing Two COVID-19 Vaccines in Healthy Adults
The purpose of this study is to compare two trial COVID-19 vaccines. We want to see if they are safe and if they help prevent COVID-19 in healthy adults aged 50 to 64. Volunteers in the study will get either one of the trial vaccines or a placebo (a shot with no vaccine). We will compare how well the vaccines work and check for any side effects.
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Healthy Volunteers Infectious Diseases Screening and Prevention
Studying a New COVID-19 Vaccine among Patients who have Received a Cell Therapy
The purpose of this study is to see if a new vaccine called GEO-CM04S1can help people who have received a cell therapy build protection from COVID-19. We want to compare this new vaccine to the current COVID-19 vaccines and see which one will work better.
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Looking for Volunteers Interested in COVID-19 Related Studies
The purpose of this study is to make a list of people who want to volunteer for research and COVID-19 vaccine studies. This list is called the STRIVE registry. People on the list will be contacted about new studies they might join. Joining the list does not mean you have to join any future studies.
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Helping the Brain Relax to Improve Sleep and Stress
The purpose of this study is to learn more about a new technology called Cereset Research (CR). It uses sounds linked to your brainwaves to help your brain relax and balance. In this study, you will continue your other current care, but will also receive sessions of CR. The goal is to see if it helps people with stress, anxiety, or trouble sleeping. We are looking for volunteers with symptoms following a concussion or traumatic brain injury (TBI), ongoing symptoms of long-COVID, or a functional movement disorder.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Studying the Drug SGR3515 for Patients with Advanced Solid Tumors
The study aims to learn about the drug SGR-3515. We want to see if it is safe and works well for treating advanced solid tumors. We also want to find the best dose and schedule for treating your cancer. We are looking for volunteers with advanced solid tumors who have either stopped benefiting from or cannot tolerate previous treatments, or whose cancer has returned.
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Study of the Drug BI 1831169 in People with Different Types of Advanced Solid Tumors
The purpose of this study is to find the best dose of the study drug, BI 1831169, for patients with advanced solid tumors. We also want to see how well the study drug may work and what side effects it may cause.
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Studying NDI-219216 for Advanced Solid Tumors with MMR deficiency
The purpose of this study is to learn more about a new medicine for advanced solid tumors. Our researchers will see if the medicine is safe and how the body handles it. The study will also look at whether the pill can help slow down or shrink certain advanced cancers.
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Studying the Medicine Depemokimab for COPD
The purpose of this study is to learn more about the medicine depemokimab. We want to see if this medicine can help people with COPD feel better. Volunteers in the study will get either the new medicine or a placebo and will be watched closely for changes in their health. The goal is to see if the medicine works and is safe for people with COPD.
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Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Understanding Fertility Choices for People with Spinal Cord Injuries
The purpose of this study is to learn how well people with spinal cord injuries understand their options for having children and how to improve that understanding. Volunteers in the study will complete an anonymous online survey, and results will be used to compare views and choices about fertility. After finishing, volunteers will be given resources with fertility information and options.
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A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
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Studying a New Medicine to Help People with COPD
The goal of this study is to see if a new medicine called lunsekimig can help people with COPD feel better. It will look at how well the medicine works for people who still have breathing problems even though they are already getting treatment. The study will also check if the medicine causes any side effects.
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Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
Study Topics
Cancer Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin Cancer: Solid Tumor
Studying Repotrectinib for Treating Solid Tumors in Children and Young Adults
The purpose of this study is to learn more about a new cancer medication called repotrectinib for children and young adults. We want to see if this medication can safely treat patients with a solid tumor that has spread from the original tumor site to the area around it or to other parts of the body. The study team will provide more information.
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Studying the Medicine BMS-986482 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine BMS-986482. We want to see if this medicine is safe and works well for patients with certain types of cancer including non-small cell lung cancer, melanoma, colorectal cancer, breast cancer, urothelial cancer, prostate cancer, head and neck cancer or gastric cancer. We will compare this medicine alone or with other approved cancer medicines.
Study Topics
Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Head, Neck Cancer: Lung Cancer: Prostate Cancer: Skin Cancer: Stomach and Intestines Cancer: Urinary and Bladder
Studying Medicines to Help People Breathe Better with COPD
The purpose if this study is to learn more about the medicines Budesonide, Glycopyrronium, and Formoterol Fumarate. We want to see how well the medicines work for preventing chronic obstructive pulmonary disease (COPD) flare-ups.
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A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
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Studying a New Treatment for Virus After Transplant
Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV/PTLD) is a virus that can happen after receiving a solid organ transplant or allogenic cell transplant. The purpose of this study is to learn more about a new treatment called tabelecleucel. We want to see how well this treatment works for patients with this virus who did not get better with a treatment called rituximab or rituximab plus chemotherapy.
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Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
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