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Learning More About How Gut Micro-organisms Play a Role in Prostate Cancer
The purpose of this study is to find out how the gut micro-organisms may affect prostate cancer that spreads to the bone. In this study, the methods required to study these gut-bone interactions will be developed and tested.
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Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
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A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
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Understanding How Chemotherapy Treatment Before Surgery Impacts Recovery
The purpose of this study is to learn how chemotherapy treatment before surgery affects your body and brain. Some people get chemotherapy before surgery, and some get it after. By looking at changes in health, doctors hope to understand how chemotherapy before surgery helps people feel better and recover faster. We are looking for volunteers who have recently been diagnosed with a gynecological cancer (ovarian, peritoneal, fallopian tube, or endometrial) and are planning to receive chemotherapy treatment followed by surgery afterwards.
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A Study of the Drug Volrustomig for Head and Neck Cancer Treatment
The study wants to learn about a drug called Volrustomig. It aims to find out if this drug is safe and helpful for people with head and neck cancer that hasn't been taken out and has spread to nearby areas. The drug will be given after patients finish their chemotherapy and radiation treatments.
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Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
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Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
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Testing a New App for Radiation Skin Rash in Head and Neck Cancer Patients
We want to learn about a new mobile app called MyCap for people with head and neck cancer who are getting radiation therapy. The study will check if the app can collect information about skin rashes caused by radiation. Volunteers will need to use their own mobile device to access the app. You are invited to join this study because you have head and neck cancer and will get radiation therapy.
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Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
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Comparing Medicines for Newly Diagnosed Multiple Myeloma
The purpose of this study is to learn which of two medicines works better for people with a newly diagnosed blood cancer called multiple myeloma. We will see how iberdomide and lenalidomide help after a stem cell transplant and how they affect health and daily life.
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Comparing Hearing Loss in Cancer Patients
The main goal of this study is to find out if there is a difference in hearing loss between cancer patients who get the treatment cisplatin and those who get the treatment carboplatin. We want to know how hearing loss affects patients in their daily lives. To find out, we will make a questionnaire that asks about your own experiences with hearing loss or hearing problems. We are looking for volunteers with germ cell tumors who have been treated with either cisplatin or carboplatin.
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Cancer Cancer: Children, Teens Cancer: Rare Cancers Cancer: Solid Tumor
Comparing Chemotherapy Schedules for Germ Cell Tumors
The purpose of this study is to find out if giving chemotherapy drugs on a faster schedule helps patients with advanced germ cell tumors. We will compare the regular 3-week cycle with a faster paced 2-week cycle. We want to see if the faster schedule is useful and safe for the patients.
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Improving Cancer Care for Young Patients
The purpose of this study to find better ways to diagnose, treat, and prevent cancers in children, teenagers, and young adults. Our goal is to gather information about cancer treatments and their results to improve future care. We are looking for volunteers who have cancer or other conditions where cells grow abnormally. The study team will provide more details.
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Studying a New Medicine for Advanced Prostate Cancer
The purpose of this study is to learn more about a new medicine called xaluritamig. We want to see if this medicine works better than the current treatment for prostate cancer that has spread and no longer responds to hormone therapy. Volunteers in the study will get either the new medicine or one of the standard treatments. Doctors will check how long people live and how well they do with each treatment.
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Comparing Two Medicines for Essential Thrombocythemia
The purpose of this study is to see if a new medicine called bomedemstat is safe and works well for people with a blood disease called essential thrombocythemia. We will compare bomedemstat to another medicine called hydroxyurea. The goal is to find out which medicine helps more with symptoms like tiredness and high platelet counts.
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Studying a Type of Blood Test Used to Find Cancer in People With Sarcoma
The purpose of this study is to look at how well a special blood test called LP-WGS can find cancer in people with bone or soft tissue sarcoma (a type of cancer).
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Learning More about Immunotherapy Before and After Skin Cancer Surgery
The purpose of this study is to learn about a new way to treat skin cancer with surgery. We want to see if giving a type of medicine called immunotherapy before and after surgery helps people stay cancer-free longer than the usual treatment. We are trying to find out if this new way works better or worse than the regular way. We are looking for volunteers who have a kind of skin cancer called cutaneous squamous cell carcinoma that can be removed with surgery.
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