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Studying the Medicine Apalutamide for Prostate Cancer After Surgery
The purpose of this study is to see if adding the medicine apalutamideo to your regular prostate cancer treatment can help stop the cancer from spreading for a longer time. We want to find out if this new way works better or worse than the usual treatment.
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Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
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Learning More About Adding TRC102 to the Usual Non-Small Cell Lung Cancer Treatment
The purpose of this study is to learn more about the study drug, TRC102. We want to see how it can affect Stage III lung cancer. TRC102 will be added to the usual treatment. The addition of TRC102 to the usual treatment could stabilize your cancer and lengthen the time you can live. This study will help the us find out if this approach is better than the usual approach.
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Study of Quick Start Durvalumab for Treating Stage III Non-Small Cell Lung Cancer
Durvalumab is usually started 30 days or more after radiation treatment. The purpose of this study is to find out if it is possible to start Durvalumab within 14 days after radiation treatment. We want to see how the quick start affects you and your cancer.
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Testing the Combination of Abemaciclib and Olaparib for Treatment of Ovarian Cancer
The purpose of this study is to learn more about using abemaciclib and olaparib to treat ovarian cancer that has returned. This study tests different doses of the drugs to find the highest dose that is safe and well tolerated. We also want to see what side effects may occur.
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Comparing Single Dose to Multiple Doses of Radiation for Patients with Cancer that Has Spread to the Brain
The purpose of this study is to find out if there are less side effects when radiation therapy is given to small areas of brain cancer over several days compared to one day. We want to find out if this approach is better or worse than the usual approach.
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Comparing Two Surgical Procedures to Reduce the Risk of Ovarian Cancer
The purpose of this study is to compare two different surgeries to reduce the risk of ovarian cancer. The study will look at the process used to decide which surgery is best for the patient. It will also look at symptoms that occur after removal of the ovaries.
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Finding Better Ways to Diagnose, Treat and Prevent Cancer in Children
The purpose of creating the database is to help find better ways to diagnose, treat and prevent cancer in children.
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Understanding How to Best Care for Patients in the Brain Tumor Clinic
This study will collect information from patients seen in the Brain Tumor Clinic at Wake Forest Baptist Comprehensive Cancer Center. The database will include the patient's symptoms, condition and response to treatment. The data will be used to understand how we can best care for patients seen in our clinic.
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Study of the Drug BI 1831169 in People with Different Types of Advanced Solid Tumors
The purpose of this study is to find the best dose of the study drug, BI 1831169, for patients with advanced solid tumors. We also want to see how well the study drug may work and what side effects it may cause.
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A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
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Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
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Testing a Radiation-Based Treatment for Prostate Cancer that has Spread
The purpose of this study is to find out if radiation treatment with Lutetium Lu 177 Dotatate can shrink or slow the growth of prostate cancer. We want to find out if this approach is better or worse than the usual approach.
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Learning More About Blood Tests to Determine if a Cancer Patient Will Respond to Treatment
Not all patients treated with immune checkpoint inhibitors respond with tumor shrinkage. Many patients have serious side effects. The purpose of this study is to develop blood tests that can help determine if patients will respond to treatment and develop side effects.
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Learning More About How Gut Micro-organisms Play a Role in Prostate Cancer
The purpose of this study is to find out how the gut micro-organisms may affect prostate cancer that spreads to the bone. In this study, the methods required to study these gut-bone interactions will be developed and tested.
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Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
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A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
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Understanding How Chemotherapy Treatment Before Surgery Impacts Recovery
The purpose of this study is to learn how chemotherapy treatment before surgery affects your body and brain. Some people get chemotherapy before surgery, and some get it after. By looking at changes in health, doctors hope to understand how chemotherapy before surgery helps people feel better and recover faster. We are looking for volunteers who have recently been diagnosed with a gynecological cancer (ovarian, peritoneal, fallopian tube, or endometrial) and are planning to receive chemotherapy treatment followed by surgery afterwards.
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Using Brain Scans to Track Brain Tumor Changes
The purpose of this study is to learn if special brain scans can give doctors better information about how brain tumors change over time. We will compare regular MRI scans with special MRI scans and, for some people, a PET scan. What we learn may help doctors care for future patients with brain cancer. This study is for volunteers diagnosed with glioblastoma.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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