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Using Ide-Cel to Treat Multiple Myeloma
The purpose of this research is to see if idecabtagene vicleucel (ide-cel) is safe and useful to treat participants with multiple myeloma.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
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Treating Vulvar Dysplasia with a New Surgical Treatment
This study is being done to see if a surgical treatment, Frozen-Section Directed Excision, is better at treating vulvar dysplasia than the usual treatment.
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Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
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Can Immunotherapy Help Non-Small Cell Lung Cancer Patients Improve Physical Function
The purpose of this study is to see if treatment with immunotherapy can help lung cancer patients who get tired easily and struggle with some daily tasks.
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Studying the Drug JNJ 88549968 for Patients with Myeloproliferative Neoplasms
Myeloproliferative neoplasms are blood cancers caused by changes in bone marrow cells. This study aims to learn more about the drug JNJ-88549968 to treat these cancers. We want to find a safe dose and see how long it stays in the body and how the body reacts to it.
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Studying the Drug JNJ-90014496 for Patients with B Cell Non-Hodgkin Lymphoma
This study aims to learn more about the drug JNJ-90014496. We want to see if this drug is safe and helpful for treating patients with B cell Non-Hodgkin Lymphoma that has come back or hasn't responded to treatment.
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A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
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Is it More Helpful to Give Children with Germ Cell Tumors Chemotherapy on a Faster Schedule
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
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Targeted Drug Treatment for Patients with Growing Brain Tumors
The purpose of this study is to see if certain drugs work better for people with meningiomas (a type of brain tumor) that have specific gene changes. The goal is to see if using genetic testing can help pick the best treatment. Researchers hope this will help shrink tumors and improve care for future patients.
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A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
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Combination Chemotherapy for Newly Diagnosed and Relapsed Wilms Tumor
The purpose of this study is to find out if we can improve treatment for those with Wilms tumors. We will be testing three different combinations of radiation and chemotherapy. The combination you receive will depend on your type of Wilms tumor.
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Cancer Cancer: Kidney, Liver, Pancreas Children, Infants, Teen Health
Comparing Multi-day Versus Single Day Radiation Therapy for Brain Cancer
This study aims to find out if giving radiation over several days causes fewer side effects than giving it in one day for brain cancer patients on immunotherapy.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Breast Cancer: Kidney, Liver, Pancreas Cancer: Lung Cancer: Skin
I-SPY 2 TRIAL: Study of New Drugs to Treat Breast Cancer Before Surgery
The purpose of this study is to learn more about giving the best treatment at the right time. Treatment on this study will be given before surgery. This allows us to better understand how different people's breast cancers respond to commonly used chemotherapy with or without new drugs.
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A Study of the Drug Fluticasone Propionate and Albuterol Sulfate to Treat Asthma
The purpose of this study is to learn more about the study drug Fluticasone Propionate and Albuterol Sulfate. We want to see how well the study drug works for treating symptoms of asthma and preventing severe asthma attacks.
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Learning More About Treating Gastric, Gastroesophageal Junction and Pancreatic Tumors with ASP2138
The purpose of this study is to find out how well the study drug, ASP2138, works for treating gastric, gastroesophageal junction or pancreatic tumors. We also want to learn more about the side effects that may be caused by the study drug.
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Cancer Cancer: Kidney, Liver, Pancreas Cancer: Stomach and Intestines
A Study of the Drug ABBV-383 for Patients with Multiple Myeloma
The purpose of this study is to learn more about the study drug ABBV-383 for patients with multiple myeloma that has returned or has not responded to treatment. We want to find the best dose and learn about the safety and effects of the study drug.
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Studying Ways to Improve Physical Activity in Young Adult Cancer Survivors
The purpose of this study to test four different ways to improve physical activity in young adult cancer survivors. We want to learn more about each approach and see which one will work best.
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Internet-Based Program to Help Cancer Survivors Manage Pain
The purpose of this study is to learn more about an internet-based pain program combined with pain education. We want to see if the pain program and education can help reduce pain and improve impact on daily activities. We also want to see if this approach is better or worse than the usual approach.
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