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Using the Study Drugs M1774 and Avelumab to Treat Merkel Cell Skin Cancer
The purpose of this study is to learn more about the study drug M1774. We want to see how well the study drug treats Merkel cell cancer when used alone and when combined with Avelumab. We want to find out if either approach is better or worse than the usual treatment.
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Low Muscle Mass and its Role in Side Effects from Colorectal Cancer Treatment in Older Adults
The purpose of this study is to find out if low muscle mass plays a role in side effects from colorectal cancer treatment.
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Collecting Blood and Tissue Samples from Patients with Blood Cancer (myeloproliferative neoplasms)
The goal of this study is to gather blood and tissue samples from patients with a type of blood cancer (myeloproliferative neoplasms). The samples will be used to help find new approaches to treatment.
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Treating Head and Neck Cancer with Cetuximab
The purpose of this study is to see how well the drug Cetuximab works for treating head/neck cancer that stopped responding to treatment. It is possible that Cetuximab may work better when given in patients who have already had immunotherapy.
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Comparing Two Different Methods of Surgery to Treat Osteosarcoma that Has Spread to the Lungs
The purpose of this study is to compare two different surgery methods for people with osteosarcoma that has spread to the lung. We want to find out which surgery method is better. One method is called open thoracic surgery. It is done through a single large cut between the ribs, opens the chest, and removes the cancer. The other method is called thoracoscopy. It is done through several small incisions and uses a small camera to help with removing the cancer. Both methods are considered standard treatment.
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Finding Out How Well Adding a Third Medication to Treatment Works for Treating Advanced Rectal Cancer
The purpose of this study is to find out if we can increase the likelihood of your tumor disappearing by adding a third drug to the usual treatment. We want to find out if this approach is better or worse than the usual approach.
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Adding Tazemetostat to the Usual Treatment for Melanoma
The purpose of this study is to find out if the study drug, tazemetostat, can keep your melanoma from getting worse. We also want to see if the study drug alone is better or worse than adding the study drug to the usual treatment.
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Learning More About Treating Glioma with the Study Drug OKN-007
The purpose of this study is to find out how well the study drug, OKN-007, works for treating glioma. We also want to determine what dose is safe and well tolerated.
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Adding the Study Drug Apalutamide to the Usual Treatment for Prostate Cancer After Surgery
The purpose of this study is to find out if we can extend the time without your prostate cancer spreading by adding the study drug to the usual treatment. We want to find out if this approach is better or worse than the usual approach for your prostate cancer.
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Learning More About Adding TRC102 to the Usual Non-Small Cell Lung Cancer Treatment
The purpose of this study is to learn more about the study drug, TRC102. We want to see how it can affect Stage III lung cancer. TRC102 will be added to the usual treatment. The addition of TRC102 to the usual treatment could stabilize your cancer and lengthen the time you can live. This study will help the us find out if this approach is better than the usual approach.
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Finding Out How Well Selinexor Works for Treating Brain Cancer
The purpose of this study is to find the safest dose of the study drug, Selinexor. We also want to find out if adding the study drug is better than the usual treatment for brain cancer.
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Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
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Study of Quick Start Durvalumab for Treating Stage III Non-Small Cell Lung Cancer
Durvalumab is usually started 30 days or more after radiation treatment. The purpose of this study is to find out if it is possible to start Durvalumab within 14 days after radiation treatment. We want to see how the quick start affects you and your cancer.
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Testing the Combination of Abemaciclib and Olaparib for Treatment of Ovarian Cancer
The purpose of this study is to learn more about using abemaciclib and olaparib to treat ovarian cancer that has returned. This study tests different doses of the drugs to find the highest dose that is safe and well tolerated. We also want to see what side effects may occur.
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Testing Different Courses of Hormone Therapy Depending on the Type of Prostate Cancer
The purpose of this study is to test different courses of hormone therapy depending on the type of prostate cancer. We are doing this study to find out if these approaches are better, similar, or worse than the usual approach for your type of prostate cancer.
Study Topics
Comparing Two Surgical Procedures to Reduce the Risk of Ovarian Cancer
The purpose of this study is to compare two different surgeries to reduce the risk of ovarian cancer. The study will look at the process used to decide which surgery is best for the patient. It will also look at symptoms that occur after removal of the ovaries.
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Comparing Single Dose to Multiple Doses of Radiation for Patients with Cancer that Has Spread to the Brain
The purpose of this study is to find out if there are less side effects when radiation therapy is given to small areas of brain cancer over several days compared to one day. We want to find out if this approach is better or worse than the usual approach.
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Using Camizestrant for Hormone Therapy to Treat ER+/HER2- Breast Cancer
The purpose of this study is to learn more about the study drug camizestrant. We want to see how well the study drug works at stopping the cancer from coming back compared to the usual treatment.
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Using Muscadine Grape Extract to Help with Fatigue Caused by Prostate Cancer Treatment
Men being treated for prostate cancer can experience fatigue. The purpose of this study is to find out if muscadine grape extract can help improve that fatigue.
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Using Ultrasound to Detect Neuropathy Caused by Chemotherapy with Oxaliplatin
The purpose of this study is to find out if ultrasound can be used to diagnose damage to nerves caused by the drug Oxaliplatin. Taking part in this study requires one visit. The visit will include ultrasound of the nerve, nerve conduction test, skin biopsy, and examination of your nerves.
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