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Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
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Collecting Data from Hemophilia Patients
The purpose of this study is to collect data on a blood disorder called hemophilia. The data will be used to improve the care of patients.
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Heart Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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Studying a New Treatment Regimen Before Surgery for Advanced Ovarian Cancer
The purpose of this study is to learn if adding a new medicine called mirvetuximab to chemotherapy (carboplatin) is safe and works well for advanced ovarian cancer. Researchers want to see if this treatment can shrink tumors before surgery so they can be removed more easily. Possible side effects of the treatment will also be studied. This study is for volunteers with advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer.
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Brain Changes after Radiation Treatment for Glioma
Glioma is a type of brain cancer. The purpose of this study is to see if we can predict how brain function will change after radiation treatment for glioma. We will be doing PET scans and blood tests with glioma patients. A PET scan is a type of test that gives us images of your brain and can help detect certain diseases.
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Finding Ways to Improve Health for Older Adults with B-cell Non-Hodgkin Lymphoma or Multiple Myeloma
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A Study on Treating Tumors that Spread to the Brain and Came Back After Radiation
This study examines different treatments for people whose brain tumors come back after radiation treatment. All patients will have a biopsy first and results will impact following treatment:
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Treating Prostate Cancer with Omeprazole and Chemotherapy
The purpose of this study is to find out how Omeprazole may help treat prostate cancer. It will be given along with chemotherapy. Researchers believe Omeprazole may help the chemotherapy work.
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Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
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Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
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Finding Therapies that Improve Survival for Patients with Glioblastomas
The purpose of this research is to test multiple study treatments for glioblastoma. We want to find out if any of these study treatments can improve how long patients live.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
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Can Immunotherapy Help Non-Small Cell Lung Cancer Patients Improve Physical Function
The purpose of this study is to see if treatment with immunotherapy can help lung cancer patients who get tired easily and struggle with some daily tasks.
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Is it More Helpful to Give Children with Germ Cell Tumors Chemotherapy on a Faster Schedule
A germ cell tumor is a type of cancer found in the ovaries for females or the testes for males. This tumor may also be found in the pelvis along the tailbone, chest, abdomen, and other structures of the body. Chemotherapy is the medicine used to fight cancer. We want to find out if giving children with germ cell tumors chemotherapy on a faster schedule is effective.
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Targeted Drug Treatment for Patients with Growing Brain Tumors
The purpose of this study is to see if certain drugs work better for people with meningiomas (a type of brain tumor) that have specific gene changes. The goal is to see if using genetic testing can help pick the best treatment. Researchers hope this will help shrink tumors and improve care for future patients.
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Combination Chemotherapy for Newly Diagnosed and Relapsed Wilms Tumor
The purpose of this study is to find out if we can improve treatment for those with Wilms tumors. We will be testing three different combinations of radiation and chemotherapy. The combination you receive will depend on your type of Wilms tumor.
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Cancer Cancer: Kidney, Liver, Pancreas Children, Infants, Teen Health
I-SPY 2 TRIAL: Study of New Drugs to Treat Breast Cancer Before Surgery
The purpose of this study is to learn more about giving the best treatment at the right time. Treatment on this study will be given before surgery. This allows us to better understand how different people's breast cancers respond to commonly used chemotherapy with or without new drugs.
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Learning More About Treating Gastric, Gastroesophageal Junction and Pancreatic Tumors with ASP2138
The purpose of this study is to find out how well the study drug, ASP2138, works for treating gastric, gastroesophageal junction or pancreatic tumors. We also want to learn more about the side effects that may be caused by the study drug.
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Cancer Cancer: Kidney, Liver, Pancreas Cancer: Stomach and Intestines