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Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
Study Topics
Using Brain Scans to Track Brain Tumor Changes
The purpose of this study is to learn if special brain scans can give doctors better information about how brain tumors change over time. We will compare regular MRI scans with special MRI scans and, for some people, a PET scan. What we learn may help doctors care for future patients with brain cancer. This study is for volunteers diagnosed with glioblastoma.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
Study Topics
Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
Study Topics
Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
Study Topics
Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
Study Topics
Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
Study Topics
Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
Study Topics
Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
Study Topics
Understanding Needs of Young People With Cancer
This study aims to learn what young people with cancer need most while getting care and after treatment. We want to understand what topics they want more education and support about, such as health, emotions, and daily life. What we learn will help improve programs and services for young people with cancer. We are looking for volunteers who were between 15 and 39 years old when they were diagnosed with cancer and are currently getting cancer treatment or have had cancer treatment in the past.
Study Topics
Studying a New CAR T Treatment for Multiple Myeloma
The purpose of this study is to learn more about a new treatment called arlo‑cel for people with multiple myeloma. The study will compare this new treatment to standard cancer medicines to see which works better and is safer. This study is for volunteers with multiple myeloma whose cancer came back or did not improve after other treatments.
Study Topics
Communities Against Cancer: A Survey for Change
The purpose of this study is to learn about how people in our area take care of their health and what challenges they face with cancer. We hope to understand what people need and how we can help them better. The answers from this survey will help us make plans to support our community.
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Comparing Two Medicines for ALK‑Positive Lung Cancer
The purpose of this study is to learn more about a new medicine called NVL‑655 for non‑small cell lung cancer that is ALK‑positive. Our researchers want to see if NVL‑655 works better and is safer than a commonly used medicine called alectinib. The goal is to learn which treatment helps stop the cancer from getting worse for a longer time.
Study Topics
Mobile App Support for Young Women with Breast Cancer
The purpose of this study is to look at a new way to better support young women with breast cancer. Our researchers will look at whether a mobile app can provide support and help lower stress. The app lets women connect with others and learn helpful information. This study is for volunteers who have been diagnosed with breast cancer at any stage.
Study Topics
Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
Study Topics
Studying a Type of Blood Test Used to Find Cancer in People With Sarcoma
The purpose of this study is to look at how well a special blood test called LP-WGS can find cancer in people with bone or soft tissue sarcoma (a type of cancer).
Study Topics
Helping Young Cancer Survivors Feel Better Using a Digital Tool
The purpose of this study is to learn more about a new digital tool to help adolescents and young adult cancer survivors manage their symptoms of depression. People in the study will use the tool, answer questions, and join a video call. The goal is to find out if the tool helps them manage their feelings better. All study visits and consultations will be done virtually.
Study Topics
Mental Health Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
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Studying New Medicine and Chemo for Rare Throat Cancer
The purpose of this study is to see if adding a new medicine called nivolumab to regular chemotherapy helps treat a rare throat cancer called nasopharyngeal carcinoma. We will also look at whether children can get less radiation and have fewer side effects. The goal is to find safer and better ways to treat this cancer.
Study Topics
Cancer Cancer: Children, Teens Cancer: Ear, Nose, Mouth, Throat