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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
Study Topics
Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying Pump Chemotherapy For Colorectal Cancer that Spread to the Liver
Hepatic arterial infusion (HAI) chemotherapy is a way to give cancer medicine straight into the liver using a small pump. The purpose of this study is to see if using this type of chemotherapy with regular chemotherapy can help people with colorectal cancer that has spread to the liver. Doctors will compare people who get both treatments to people who get only regular chemotherapy. The goal is to find out which treatment helps patients live longer and feel better.
Study Topics
Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
Study Topics
Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
Study Topics
Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
Study Topics
Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
Study Topics
Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
Study Topics
Studying the Medicine BMX-001 to Reduce Mouth Sores in Head and Neck Cancer
The purpose of this study is to learn more about the medicine BMX-00. We want to see if adding this medicine to usual chemotherapy and radiation can help lower the chance or severity of mouth sores and pain in people with head and neck cancer. People in the study will get either BMX-001 or a placebo, along with their regular treatment. The goal is to see if BMX-001 works better than the usual care for these side effects.
Study Topics
Studying an App to Help Cancer Patients Sleep Better
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
Study Topics
Studying a New Medicine for Advanced Bladder Cancer
The purpose of this study is to learn more about the medicine called Disitamab Vedotin. We want to see if this medicine helps people with advanced bladder cancer that has a certain protein called HER2. We will check if the medicine can shrink or slow down the cancer and if it is safe for patients. Doctors will also look at how the treatment affects how people feel and their quality of life.
Study Topics
Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
Study Topics
Understanding Cancer Fatigue in Survivors
Cancer-related tiredness is a common issue for people who have cancer or have been treated for it. This study aims to understand how cancer survivors and their doctors discuss this tiredness. We want to make a useful poster for exam rooms to improve talking about, diagnosing, and treating this tiredness. We are seeking cancer survivor volunteers who have had at least 1 visit with the Supportive Oncology team at Levine Cancer Institute or the Charlotte or Winston-Salem campus of Atrium Health Wake Forest Baptist Comprehensive Cancer Center. This study will last around 6 months.
Study Topics
Studying Genes and Weight Loss in Patients with Pancreatic Cancer
The purpose of this study is to understand how genes are related to weight loss in people with pancreatic cancer. Weight loss is a common issue for those with pancreatic cancer and can make life more difficult and treatments less useful. We hope to learn how to better treat and help future patients. We are seeking volunteers who have pancreatic cancer that has spread and cannot be removed by surgery.
Study Topics
Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
Study Topics
Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
Study Topics
Testing New Melanoma Treatments
The purpose of this study is to test two new drugs, fianlimab and cemiplimab, for patients with melanoma that can't be removed or has spread. We want to compare these drugs to another treatment called Opdualag. The goal is to see how safe and effective the new drugs are.
Study Topics
Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
Study Topics
Testing the Study Drug ABBV-383 for Patients with Multiple Myeloma
The goal of this study is to learn more about the drug ABBV-383. We want to find out if this drug is safe, helpful, and easy to handle when given to adults whose multiple myeloma has returned or didn't improve.
Study Topics
Checking for AL Amyloidosis among Patients with Smoldering Multiple Myeloma
Smoldering Multiple Myeloma is a blood disorder that can become a more serious cancer called multiple myeloma. This study aims to find out if checking for certain genes is connected to the development of AL amyloidosis in people aged 40 or older with this disorder.
Study Topics
Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
Study Topics