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Studying the Medicine Sonrotoclax for Patients with Blood Cancer
The purpose of this study is to learn more about a new medicine called sonrotoclax. We want to see if this medicine works better and is safe for people with a type of blood cancer called chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). We will compare the medicine to other approved treatments to see which one helps more. The goal is to help people feel better and live longer.
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Comparing Two Medicines for CLL and SLL Blood Cancer
The purpose of this study is to see how two different medicines work for people with a type of blood cancer called CLL or SLL. We will compare how safe the medicines are and how well they help control the cancer. Our researchers hope to find out which medicine works better for people whose cancer has already been treated.
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A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about a new study catheter. We want to see if this catheter can help treat episodes of rapid heartbeat in patients with heart problems not caused by blocked arteries or heart attacks. We want to learn more about the safety and effectiveness of this catheter.
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Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Graft-versus-host disease happens when the new cells from a stem cell transplant attack the patient's own body cells. This study aims to learn more about a new medicine called ruxolitinib to prevent this disease after a stem cell transplant. We will compare this medicine to the standard treatment. Volunteers must be planning to undergo a stem cell transplant for leukemia or lymphoma. The study team will provide more information.
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A Study of the Drug AZD5492 for Blood Cancer
The purpose of this study to learn more about the study drug AZD5492. We want to see if this study drug is safe and helpful for treating blood cancers that have not gotten better with other treatments. We need volunteers with certain types of blood cancer like B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma. The study team will provide more information.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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Studying a New Treatment Plan for Patients with Large B-cell Lymphoma or Grade IIIB Follicular Lymphoma
We are looking for volunteers with Grade IIIB Follicular or Relapsed/Refractory Diffuse Large B-cell Lymphoma. The purpose of this study is to see if we can reduce the chance of your cancer growing or spreading by adding more treatment to the usual therapy. We are doing this study to see if this new approach is better or worse than the usual approach for patients who are getting CAR T-cell therapy.
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Studying a New Medicine for B-cell Non-Hodgkin Lymphoma
The purpose of this study is to learn more about a new medicine called AZD0486. This medicine is for people with a type of cancer called B-cell non-Hodgkin lymphoma that has come back or did not get better with other treatments. The goal is to see if this medicine is safe and if it helps shrink or stop the cancer.
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Early Detection Matters
The purpose of this study is to test recruitment methods to find and sign up people for a blood screening study. The results will help us decide if we can do a bigger study later. You are invited to join because you are at least 30 years old, self-identify as Black and/or African American or are at higher risk for developing MGUS because of a first-degree relative and, live in Charlotte, NC or nearby. This study will also check how many people have a blood condition that might lead to blood cancer.
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Minority Health Screening and Prevention Cancer Cancer: Blood
Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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Studying a New Add‑On Treatment for Aggressive B‑Cell Lymphoma
The purpose of this study is to learn more about a new study medicine called golcadomide when it is added to standard chemotherapy. Our researchers want to see if this new medicine is safe and if it helps control aggressive B cell lymphoma better than standard treatment alone. They will also study how the medicine works in the body.
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Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
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Studying Extra Therapies People Use During Cancer Treatment
The purpose of this study to learn more about other ways people manage their cancer symptoms while they are getting treatment. These other ways include using things like cannabis (also called marijuana), vitamins or supplements, and doing activities like acupuncture or meditation. We want to find out if these methods help or hurt people compared to the usual care they get from their doctor.
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Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Lung Cancer: Lymphoma Cancer: Skin
Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
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Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Studying CAR T-Cell Therapy for Aggressive B-Cell Lymphoma
The purpose of this research is to find new ways to treat lymphomas that have come back or stopped responding to treatment. Researchers will study a new cell therapy made from a person's own immune cells for aggressive B‑cell lymphoma. The study looks at how safe this treatment is and how well it helps shrink or control the cancer.
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Learning More About The Medicine Duvelisib T-cell Lymphoma
The purpose of this study is to learn more about treating peripheral T-cell lymphoma with the study drug Duvelisib or Azacitidine. One of the study drugs will be given along with the usual treatment. We want to see how well the combination treatment works. We also want to learn more about possible side effects.
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Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
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Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
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Finding Ways to Improve Health for Older Adults with B-cell Non-Hodgkin Lymphoma or Multiple Myeloma
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
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