Search Studies
A Study of the Drug ABBV-383 for Patients with Multiple Myeloma
The purpose of this study is to learn more about the study drug ABBV-383 for patients with multiple myeloma that has returned or has not responded to treatment. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
Low Muscle Mass and its Role in Side Effects from Colorectal Cancer Treatment in Older Adults
The purpose of this study is to find out if low muscle mass plays a role in side effects from colorectal cancer treatment.
Study Topics
Collecting Blood and Tissue Samples from Patients with Blood Cancer (myeloproliferative neoplasms)
The goal of this study is to gather blood and tissue samples from patients with a type of blood cancer (myeloproliferative neoplasms). The samples will be used to help find new approaches to treatment.
Study Topics
Comparing Two Different Methods of Surgery to Treat Osteosarcoma that Has Spread to the Lungs
The purpose of this study is to compare two different surgery methods for people with osteosarcoma that has spread to the lung. We want to find out which surgery method is better. One method is called open thoracic surgery. It is done through a single large cut between the ribs, opens the chest, and removes the cancer. The other method is called thoracoscopy. It is done through several small incisions and uses a small camera to help with removing the cancer. Both methods are considered standard treatment.
Study Topics
Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
Study Topics
Testing the Combination of Abemaciclib and Olaparib for Treatment of Ovarian Cancer
The purpose of this study is to learn more about using abemaciclib and olaparib to treat ovarian cancer that has returned. This study tests different doses of the drugs to find the highest dose that is safe and well tolerated. We also want to see what side effects may occur.
Study Topics
Study of Quick Start Durvalumab for Treating Stage III Non-Small Cell Lung Cancer
Durvalumab is usually started 30 days or more after radiation treatment. The purpose of this study is to find out if it is possible to start Durvalumab within 14 days after radiation treatment. We want to see how the quick start affects you and your cancer.
Study Topics
Comparing Two Surgical Procedures to Reduce the Risk of Ovarian Cancer
The purpose of this study is to compare two different surgeries to reduce the risk of ovarian cancer. The study will look at the process used to decide which surgery is best for the patient. It will also look at symptoms that occur after removal of the ovaries.
Study Topics
Finding Better Ways to Diagnose, Treat and Prevent Cancer in Children
The purpose of creating the database is to help find better ways to diagnose, treat and prevent cancer in children.
Study Topics
Understanding How to Best Care for Patients in the Brain Tumor Clinic
This study will collect information from patients seen in the Brain Tumor Clinic at Wake Forest Baptist Comprehensive Cancer Center. The database will include the patient's symptoms, condition and response to treatment. The data will be used to understand how we can best care for patients seen in our clinic.
Study Topics
A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
Study Topics
Testing a Radiation-Based Treatment for Prostate Cancer that has Spread
The purpose of this study is to find out if radiation treatment with Lutetium Lu 177 Dotatate can shrink or slow the growth of prostate cancer. We want to find out if this approach is better or worse than the usual approach.
Study Topics
Learning More About Blood Tests to Determine if a Cancer Patient Will Respond to Treatment
Not all patients treated with immune checkpoint inhibitors respond with tumor shrinkage. Many patients have serious side effects. The purpose of this study is to develop blood tests that can help determine if patients will respond to treatment and develop side effects.
Study Topics
Learning More About How Gut Micro-organisms Play a Role in Prostate Cancer
The purpose of this study is to find out how the gut micro-organisms may affect prostate cancer that spreads to the bone. In this study, the methods required to study these gut-bone interactions will be developed and tested.
Study Topics
Learning More About a New Approach to Treating Ductal Carcinoma In Situ
Some ductal carcinoma in situ (breast cancer) is lower risk than others for turning into invasive cancer. The purpose of this study is to try and figure out which ductal carcinoma in situ is low risk. It's possible low-risk breast cancer can be treated with only hormone therapy pills and avoid surgery.
Study Topics
A Study of Methotrexate in People with Breast, Brain, or Spinal Cord Cancer
Methotrexate is a type of chemotherapy drug. The purpose of this study is to find out how well high-dose Methotrexate works for treating breast cancer that has spread to the membrane that cover the brain and spinal cord. We also want to find out what the side effects of this treatment may be. Methotrexate will be given to study volunteers in the hospital every 2 weeks until there is evidence that the cancer is growing.
Study Topics
Studying New Treatments for Children and Young Adults With Relapsed B-ALL
The purpose of this study is to look at a new way to treat a blood cancer called B-ALL that has come back after prior treatment. Researchers will see if the medicine combination of blinatumomab and nivolumab is more effective than blinatumomab alone. The goal is to find safer treatments that help people stay healthy longer.
Study Topics
Understanding How Chemotherapy Treatment Before Surgery Impacts Recovery
The purpose of this study is to learn how chemotherapy treatment before surgery affects your body and brain. Some people get chemotherapy before surgery, and some get it after. By looking at changes in health, doctors hope to understand how chemotherapy before surgery helps people feel better and recover faster. We are looking for volunteers who have recently been diagnosed with a gynecological cancer (ovarian, peritoneal, fallopian tube, or endometrial) and are planning to receive chemotherapy treatment followed by surgery afterwards.
Study Topics
Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
Study Topics