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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
Study Topics
Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
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Studying Chemo Before Surgery for Abdominal Sarcoma
The purpose of this study is to learn more about giving chemotherapy before surgery for a type of cancer called retroperitoneal sarcoma. We want to see if this helps lower the chance of the cancer coming back. We will compare two groups: one that gets surgery only and one that gets chemotherapy first and then surgery. This will help doctors learn which treatment works better in the future.
Study Topics
Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
Study Topics
Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
Study Topics
Studying the Medicine BMX-001 to Reduce Mouth Sores in Head and Neck Cancer
The purpose of this study is to learn more about the medicine BMX-00. We want to see if adding this medicine to usual chemotherapy and radiation can help lower the chance or severity of mouth sores and pain in people with head and neck cancer. People in the study will get either BMX-001 or a placebo, along with their regular treatment. The goal is to see if BMX-001 works better than the usual care for these side effects.
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Studying a New Medicine for Advanced Bladder Cancer
The purpose of this study is to learn more about the medicine called Disitamab Vedotin. We want to see if this medicine helps people with advanced bladder cancer that has a certain protein called HER2. We will check if the medicine can shrink or slow down the cancer and if it is safe for patients. Doctors will also look at how the treatment affects how people feel and their quality of life.
Study Topics
Studying Genes and Weight Loss in Patients with Pancreatic Cancer
The purpose of this study is to understand how genes are related to weight loss in people with pancreatic cancer. Weight loss is a common issue for those with pancreatic cancer and can make life more difficult and treatments less useful. We hope to learn how to better treat and help future patients. We are seeking volunteers who have pancreatic cancer that has spread and cannot be removed by surgery.
Study Topics
Understanding Cancer Fatigue in Survivors
Cancer-related tiredness is a common issue for people who have cancer or have been treated for it. This study aims to understand how cancer survivors and their doctors discuss this tiredness. We want to make a useful poster for exam rooms to improve talking about, diagnosing, and treating this tiredness. We are seeking cancer survivor volunteers who have had at least 1 visit with the Supportive Oncology team at Levine Cancer Institute or the Charlotte or Winston-Salem campus of Atrium Health Wake Forest Baptist Comprehensive Cancer Center. This study will last around 6 months.
Study Topics
Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
Study Topics
Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
Study Topics
Testing New Melanoma Treatments
The purpose of this study is to test two new drugs, fianlimab and cemiplimab, for patients with melanoma that can't be removed or has spread. We want to compare these drugs to another treatment called Opdualag. The goal is to see how safe and effective the new drugs are.
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Checking for AL Amyloidosis among Patients with Smoldering Multiple Myeloma
Smoldering Multiple Myeloma is a blood disorder that can become a more serious cancer called multiple myeloma. This study aims to find out if checking for certain genes is connected to the development of AL amyloidosis in people aged 40 or older with this disorder.
Study Topics
Testing Cancer Drug Doses for Older Adults with Breast Cancer
The purpose of this study is to test two cancer drugs, palbociclib and ribociclib. We want to find the best dose for older adults with breast cancer. We want to help patients stay on treatment longer with fewer side effects. The study is for volunteers with hormone receptor-positive, HER2-negative breast cancer that has spread to another part of the body.
Study Topics
Testing the Study Drug XmAb819 for Patients with Kidney Cancer
The purpose of this study is to test a new drug called XmAb819. We want to see if this study drug is safe and works well for volunteers with clear cell renal cell carcinoma that has come back or not responded to other treatments.
Study Topics
Studying the Drug SGR3515 for Patients with Advanced Solid Tumors
The study aims to learn about the drug SGR-3515. We want to see if it is safe and works well for treating advanced solid tumors. We also want to find the best dose and schedule for treating your cancer. We are looking for volunteers with advanced solid tumors who have either stopped benefiting from or cannot tolerate previous treatments, or whose cancer has returned.
Study Topics
Learning About Tiredness in Lung Cancer Patients
We want to understand why people with a type of lung cancer feel tired. We also want to know if exercise can help and how caregivers can support patients in staying active. We are looking for volunteers who have a type of lung cancer called non-small cell lung cancer or are caregivers for someone with it. This study will last around 3 months.
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Studying Opioid Use After Cancer Surgery
The purpose of this study is to see how many pain pills are taken by cancer patients after surgery. We also want to see how patients get rid of leftover pills and how happy they are with their care. We are looking for volunteers who are already scheduled to have surgery to remove their bladder, kidney, or prostate because of cancer at Atrium Health Wake Forest Baptist Comprehensive Cancer Center.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Cancer: Prostate Cancer: Urinary and Bladder
Studying a New Biomarker to Predict Breast Cancer Return
The goal of this study is to learn more about a new test called Oncodetect™. This test looks for signs of breast cancer in the blood. We want to see how well this test can find cancer coming back during and after treatments like surgery or radiation.
Study Topics
Using a Blood Test to Guide Colon Cancer Treatment
The purpose of this study is to find out if a blood test can help doctors choose the best kind of chemotherapy for people who had surgery for colon cancer. This blood test looks for something called ctDNA. ctDNA is tiny pieces of DNA from cancer cells that can be found in your blood. We want to see if using this blood test is better or worse than the usual way of deciding on treatment. We are looking for volunteers who have colon cancer and have been treated with surgery.
Study Topics