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Comparing Treatments for Patients with Newly Diagnosed AML
The purpose of this study is to see how well the study drug, CPX-351 works for treating acute myeloid leukemia. We want to find out if this approach works better than the usual approach. We also want to learn more about the possible side effects of this treatment.
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Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to find out if the breast cancer medicine trastuzumab deruxtecan (T-DXd) is safe when given as a shot under the skin. The medicine is already used through an IV, but our researchers will study a quicker way to give it. We hope this new way will help people with advanced breast cancer.
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Studying a Breast Cancer Medicine Given Under the Skin
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
Study Topics
Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
Study Topics
Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Studying Chemo Before Surgery for Abdominal Sarcoma
The purpose of this study is to see if a new medicine called anifrolumab helps people with muscle weakness diseases called polymyositis and dermatomyositis. The medicine will be given as a shot under the skin, along with regular treatment. The study will check if this medicine helps people feel better and need less of their usual medicine.
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Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
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Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
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Studying the Medicine Olutasidenib for AML After Venetoclax
The purpose of this study is to learn more about the medicine olutasidenib. Researchers want to see if this medicine can help adults with a type of blood cancer called acute myeloid leukemia (AML) that has come back or has not improved after treatment with venetoclax.
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Studying Axatilimab for Children and Teens with Chronic Graft‑Versus‑Host Disease
Chronic graft‑versus‑host disease (GVHD) is a condition where donated stem cells attack the patient's body after a transplant, causing ongoing health problems. The purpose of this study is to learn more about the medicine axatilimab for children and teens with this condition. The goal is to see if this treatment works better and is safe compared to other medicines already used.
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Studying the Medicine BMX-001 to Reduce Mouth Sores in Head and Neck Cancer
The purpose of this study is to learn more about the medicine BMX-00. We want to see if adding this medicine to usual chemotherapy and radiation can help lower the chance or severity of mouth sores and pain in people with head and neck cancer. People in the study will get either BMX-001 or a placebo, along with their regular treatment. The goal is to see if BMX-001 works better than the usual care for these side effects.
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Testing Treatment Before Surgery for Advanced Head and Neck Cancer
This study is testing whether giving chemotherapy or chemo-immunotherapy before surgery works better than surgery alone for advanced head and neck cancer. Researchers want to learn if this approach can help more people stay cancer-free after treatment.
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Studying a New Medicine for Advanced Bladder Cancer
The purpose of this study is to learn more about the medicine called Disitamab Vedotin. We want to see if this medicine helps people with advanced bladder cancer that has a certain protein called HER2. We will check if the medicine can shrink or slow down the cancer and if it is safe for patients. Doctors will also look at how the treatment affects how people feel and their quality of life.
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Studying Genes and Weight Loss in Patients with Pancreatic Cancer
The purpose of this study is to understand how genes are related to weight loss in people with pancreatic cancer. Weight loss is a common issue for those with pancreatic cancer and can make life more difficult and treatments less useful. We hope to learn how to better treat and help future patients. We are seeking volunteers who have pancreatic cancer that has spread and cannot be removed by surgery.
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Understanding Cancer Fatigue in Survivors
Cancer-related tiredness is a common issue for people who have cancer or have been treated for it. This study aims to understand how cancer survivors and their doctors discuss this tiredness. We want to make a useful poster for exam rooms to improve talking about, diagnosing, and treating this tiredness. We are seeking cancer survivor volunteers who have had at least 1 visit with the Supportive Oncology team at Levine Cancer Institute or the Charlotte or Winston-Salem campus of Atrium Health Wake Forest Baptist Comprehensive Cancer Center. This study will last around 6 months.
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Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
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Testing New Melanoma Treatments
The purpose of this study is to test two new drugs, fianlimab and cemiplimab, for patients with melanoma that can't be removed or has spread. We want to compare these drugs to another treatment called Opdualag. The goal is to see how safe and effective the new drugs are.
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Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
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Checking for AL Amyloidosis among Patients with Smoldering Multiple Myeloma
Smoldering Multiple Myeloma is a blood disorder that can become a more serious cancer called multiple myeloma. This study aims to find out if checking for certain genes is connected to the development of AL amyloidosis in people aged 40 or older with this disorder.
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Testing Cancer Drug Doses for Older Adults with Breast Cancer
The purpose of this study is to test two cancer drugs, palbociclib and ribociclib. We want to find the best dose for older adults with breast cancer. We want to help patients stay on treatment longer with fewer side effects. The study is for volunteers with hormone receptor-positive, HER2-negative breast cancer that has spread to another part of the body.
Study Topics