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Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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Studying a New Medicine for Polycythemia Vera
Polycythemia vera is a blood disease where the body makes too many red blood cells. The purpose of this study is to learn more about a new medicine called DISC 3405 for this disease. Our researchers will look at how the medicine works in the body and what dose works best.
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Studying the Medicine Erdafitinib for Brain Cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
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Studying a New Medicine for Heart and Lung Health
The purpose of this study is to learn if adding a new medicine called mirvetuximab to chemotherapy (carboplatin) is safe and works well for advanced ovarian cancer. Researchers want to see if this treatment can shrink tumors before surgery so they can be removed more easily. Possible side effects of the treatment will also be studied. This study is for volunteers with advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer.
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Brain Changes after Radiation Treatment for Glioma
Glioma is a type of brain cancer. The purpose of this study is to see if we can predict how brain function will change after radiation treatment for glioma. We will be doing PET scans and blood tests with glioma patients. A PET scan is a type of test that gives us images of your brain and can help detect certain diseases.
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Finding Ways to Improve Health for Older Adults with B-cell Non-Hodgkin Lymphoma or Multiple Myeloma
The purpose of this study is to see if we can decrease CAR-T therapy side effects. We also want to see if we can improve care in older adults with non-Hodgkin lymphoma or multiple myeloma. Pre-treatment assessments will be done to identify weaknesses and guide referrals for additional care if needed. We want to see if this approach will improve health for patients.
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Looking at How Estrogen Deprivation Affects Heart Function in Breast Cancer Patients
The purpose of this study is to learn more about how near complete estrogen deprivation therapy effects the heart in breast cancer patients. We want to understand if this therapy changes how the heart works.
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Can Physical Activity Be Helpful for Lymphoma Patients During Treatment?
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Treating Prostate Cancer with Omeprazole and Chemotherapy
The purpose of this study is to find out how Omeprazole may help treat prostate cancer. It will be given along with chemotherapy. Researchers believe Omeprazole may help the chemotherapy work.
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Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
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Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
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Blood Test to Guide Chemotherapy After Colon Cancer Surgery
This study wants to see if a blood test can help doctors decide which chemotherapy is best after colon cancer surgery. The blood test looks for cancer DNA in the blood. The goal is to find out if this new way is better, the same, or worse than the usual treatment.
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Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
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Treating Prostate Cancer with AMG 509
The purpose of this study is to see how well the study drug, AMG 509, treats prostate cancer. We also want to learn about any side effects caused by the study drug.
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Finding Therapies that Improve Survival for Patients with Glioblastomas
The purpose of this research is to test multiple study treatments for glioblastoma. We want to find out if any of these study treatments can improve how long patients live.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
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