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Studying a New mRNA Medicine for Blood Cancer
The purpose of this study is to learn more about a new medicine called mRNA-2808 for people with multiple myeloma, a type of blood cancer. This medicine helps teach your immune system how to find and kill cancer cells. The goal is to see if the medicine is safe and to find the best dose. Researchers will also study how it affects the cancer and the body.
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Studying a New Medicine for a Rare Blood Cancer - Chronic Myeloid Leukemia (CML)
The purpose of this study is to learn more about a medicine for a rare blood cancer called chronic myeloid leukemia. We want to see if the medicine TERN-701 can safely stop or slow down cancer. This study is for patients with chronic myeloid leukemia (CML) who have already tried other treatments that did not work or caused problems.
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Studying New Treatments for Multiple Myeloma That Came Back
The purpose of this study is to find better ways to treat a type of cancer called multiple myeloma. We want to see if using different mixes of medicines works better than the usual treatment for people whose cancer came back or did not get better with other treatments. We also want to learn which medicines help the most, and check for any side effects to make sure the treatments are safe.
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Studying a New Medicine Combination for Advanced Breast Cancer
The purpose of this study is to learn if a new medicine (GDC‑4198), alone or with another medicine, is safe and works for people with advanced breast cancer. The study will also compare this new treatment to a standard treatment. Researchers want to find the best dose and see how well the treatments help control the cancer. This study is for volunteers with type of breast cancer that is hormone receptor‑positive and HER2‑negative that has spread or cannot be removed by surgery and has already been treated with a CDK4/6 inhibitor.
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Comparing Two Medicines for CLL and SLL Blood Cancer
The purpose of this study is to see how two different medicines work for people with a type of blood cancer called CLL or SLL. We will compare how safe the medicines are and how well they help control the cancer. Our researchers hope to find out which medicine works better for people whose cancer has already been treated.
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Studying Diet and Exercise During Leukemia Treatment
The purpose of this study is to learn if eating fewer calories and being more active during early leukemia treatment can help chemotherapy work better. The study also looks at whether a healthy diet and exercise plan can limit weight and body fat gain during treatment. This study is for volunteers who have been recently diagnosed with B‑cell acute lymphoblastic leukemia (B‑ALL) and are starting their first course of chemotherapy.
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Studying the Medicine MK-2870 for Breast Cancer After Surgery
The purpose of this study is to learn more about a new medicine called MK-2870. We want to see if this medicine works better than current treatments for people with triple-negative breast cancer who had surgery but still have cancer. Our researchers want to see which treatment helps people live longer and feel better. They also want to learn about side effects and how safe the new medicine is.
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Studying the Medicine Pasritamig for Advanced Prostate Cancer
The purpose of this study is to learn more about a treatment called pasritamig for people with advanced prostate cancer. Our researchers want to learn if adding pasritamig to standard treatment works better than standard treatment alone and how safe it is for patients.
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Studying the Medicine BMS-986482 for Advanced Solid Tumors
The purpose of this study is to learn more about the medicine BMS-986482. We want to see if this medicine is safe and works well for patients with certain types of cancer including non-small cell lung cancer, melanoma, colorectal cancer, breast cancer, urothelial cancer, prostate cancer, head and neck cancer or gastric cancer. We will compare this medicine alone or with other approved cancer medicines.
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Cancer Cancer: Breast Cancer: Colon, Rectum, Anus Cancer: Head, Neck Cancer: Lung Cancer: Prostate Cancer: Skin Cancer: Stomach and Intestines Cancer: Urinary and Bladder
A Study of the Drug ABBV-525 to Treat B-cell NonHodgkin's Lymphoma
The purpose of this study is to learn more about the study drug ABBV-525. We want to see if this study drug is safe and useful for the treatment of B-cell non-Hodgkin's Lymphoma that has returned or is not responding to current treatment. We also want to learn about the side effects that may be caused by taking this drug.
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Studying NDI-219216 for Advanced Solid Tumors with MMR deficiency
The purpose of this study is to learn more about a new medicine for advanced solid tumors. Our researchers will see if the medicine is safe and how the body handles it. The study will also look at whether the pill can help slow down or shrink certain advanced cancers.
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Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Graft-versus-host disease happens when the new cells from a stem cell transplant attack the patient's own body cells. This study aims to learn more about a new medicine called ruxolitinib to prevent this disease after a stem cell transplant. We will compare this medicine to the standard treatment. Volunteers must be planning to undergo a stem cell transplant for leukemia or lymphoma. The study team will provide more information.
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A Study of the Drug AZD5492 for Blood Cancer
The purpose of this study to learn more about the study drug AZD5492. We want to see if this study drug is safe and helpful for treating blood cancers that have not gotten better with other treatments. We need volunteers with certain types of blood cancer like B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma. The study team will provide more information.
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Learning More About Using ABBV-383 to Treat Amyloidosis
The purpose of this study is to find out how safe and effective the study drug, ABBV-383, is in treating people with with amyloidosis.
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Cancer Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin Cancer: Solid Tumor
Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
Study Topics
Cancer Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin Cancer: Solid Tumor
Testing a New Drug Combination for Patients with Myelofibrosis
The purpose of this study is to learn more about using two drugs called navtemadlin and ruxolitinib. We want to see if taking both drugs together helps treat patients with myelofibrosis. We also want to see if people can handle taking the drugs.
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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
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Using Ziftomenib to Treat Myeloid Leukemia
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Studying IM-1021 for Advanced Cancer
The purpose of this study is to learn more about a new medicine called IM-1021. Researchers want to see if this medicine can safely help people with advanced B-cell lymphomas. They will also find the best dose of it and see if it can help slow or shrink cancer.
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