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Comparing Treatments for Severe Aplastic Anemia in Young People
The purpose of this study is to find out whether immune suppressive therapy or bone marrow transplant is better for treating a disease called severe aplastic anemia in young patients who don't have a matched sibling donor.
Study Topics
Rare Disease Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Using Levocarnitine to Protect the Liver During Chemotherapy
The study aims to find out if the study drug, levocarnitine, can reduce severe liver damage caused by chemotherapy in patients with certain cancers.
Study Topics
Kidneys, Liver, Pancreas Cancer Cancer: Leukemia Cancer: Lymphoma
Testing New Treatments for Multiple Myeloma
The purpose of this study is to test a new mix of drugs for people with a type of blood cancer called multiple myeloma. We want to see if adding a new drug, belantamab mafodotin, to the usual treatment of carfilzomib, lenalidomide, and dexamethasone works better. This study will help doctors find out if this new mix helps patients live longer and feel better.
Study Topics
Testing the Study Drug Tegavivint for Advanced Liver Cancer
The purpose of this study is to learn more about the study drug tegavivint. We want to see if this study drug is safe and useful to treat patients with liver cancer. Volunteers must be diagnosed with liver cancer that cannot be removed surgery and is worsening. Study team will provide more information.
Study Topics
Using Zanubrutinib to Treat Lymphoma
The purpose of this study is to see if the study drug, zanubrutinib, works better than the current treatment. The study will compare how well the new drug works, how safe it is, and how it affects the quality of life of the participants.
Study Topics
Using Tagraxofusp to Treat Cancer in Young People
The purpose of this study is to see if adding the study drug, Tagraxofusp, to the usual treatment helps people with refractory (difficult to treat) and/or relapsed (cancer that has returned after previous treatment) hematologic malignancy (cancer). We also want to learn more about any side effects of the study drug.
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Using Ide-Cel to Treat Multiple Myeloma
The purpose of this research is to see if idecabtagene vicleucel (ide-cel) is safe and useful to treat participants with multiple myeloma.
Study Topics
Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
Study Topics
Testing the Addition of chemotherapy to Hormonal Therapy for Breast Cancer
The purpose of this study is to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. We want to know if adding chemotherapy to hormonal therapy helps people with breast cancer.
Study Topics
Treating Vulvar Dysplasia with a New Surgical Treatment
This study is being done to see if a surgical treatment, Frozen-Section Directed Excision, is better at treating vulvar dysplasia than the usual treatment.
Study Topics
Using Selinexor to Treat Endometrial Carcinoma
The purpose of this study is to find out if the study drug, selinexor, is safe and effective for treating a type of cancer called endometrial carcinoma.
Study Topics
Studying the Drug JNJ 88549968 for Patients with Myeloproliferative Neoplasms
Myeloproliferative neoplasms are blood cancers caused by changes in bone marrow cells. This study aims to learn more about the drug JNJ-88549968 to treat these cancers. We want to find a safe dose and see how long it stays in the body and how the body reacts to it.
Study Topics
Studying the Drug JNJ-90014496 for Patients with B Cell Non-Hodgkin Lymphoma
This study aims to learn more about the drug JNJ-90014496. We want to see if this drug is safe and helpful for treating patients with B cell Non-Hodgkin Lymphoma that has come back or hasn't responded to treatment.
Study Topics
A Study of the Drug AZD8205 for Treatment of Advanced Solid Tumors
The goal of this study is to learn more about the drug AZD8205 for treating serious tumors. We want to see if this drug is safe and if people can handle it well when used alone or with other cancer-fighting drugs. The study team will give more information about who can join the study.
Study Topics
A Study of the Drug OP-1250 for Advanced Breast Cancer Patients
The purpose of this study is to learn about the drug OP-1250 when used with either ribociclib or alpelisib. We want to see if this drug is safe and helpful for patients with advanced breast cancer or breast cancer that has spread, which is hormone receptor-positive and HER2-negative. We also want to find the best dose of this drug.
Study Topics
Treating Breast Cancer with a Combination of Drugs
The purpose of this study is to see how safe and effective the study drugs, trilaciclib, pembrolizumab, gemcitabine, and carboplatin, are in treating a type of cancer called Metastatic Triple-Negative Breast Cancer.
Study Topics
Testing Mosunetuzumab for Follicular Lymphoma
The purpose of this study is to learn more about the study drug Mosunetuzumab for patients with follicular lymphoma. We want to see if this study drug is better or worse than the usual treatment. We also want to learn about the sides effects of taking this drug.
Study Topics
Learning More About Using Ipatasertib to Treat Endometrial Cancer
The purpose of this study is to find out if adding the study drug, ipatasertib, to the usual treatment can help prevent cancer from growing or spreading.
Study Topics
Testing a New Drug System Called TAR-210 for Bladder Cancer
The purpose of this study is to learn more about a drug system called TAR210. We want to see if this drug system works better than regular bladder cancer. This study is for patients with a type of bladder cancer called Intermediate-Risk Non-Muscle-Invasive Bladder Cancer that has changes in a gene called FGFR.
Study Topics
Treating Rectal Cancer with Irinotecan
This study is about testing a new way to treat advanced rectal cancer. The researchers want to see if adding the study drug, irinotecan, to the usual treatment will help more patients have their tumors disappear and stay cancer-free longer.
Study Topics