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Studying a New Vaccine for Brain Cancer
The purpose of this study is to learn more about a new vaccine created from tumor tissue. We want to see if it can help treat patients with brain cancer after surgery, chemotherapy, and radiation. The vaccine may help your body fight cancer better. The study will also help doctors learn how to improve treatment for future patients.
Study Topics
Testing a New App for Radiation Skin Rash in Head and Neck Cancer Patients
We want to learn about a new mobile app called MyCap for people with head and neck cancer who are getting radiation therapy. The study will check if the app can collect information about skin rashes caused by radiation. Volunteers will need to use their own mobile device to access the app. You are invited to join this study because you have head and neck cancer and will get radiation therapy.
Study Topics
Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
Study Topics
Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Comparing Metformin and Insulin for Gestational Diabetes
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
Study Topics
Studying a New Bladder Pain Treatment
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a condition that causes pain in the bladder and makes you feel like you need to pee often, even if your bladder is not full. The purpose of this study is to learn more about a new medicine called VNX001 for this condition. Our researchers want to learn if it is safe and works well for patients.
Study Topics
A Study of the Drug Seladelpar for Liver Disease and Scarring of the Liver
The purpose of this study is to learn more about the study drug Seladelpar. We want to see if the study drug can help treat patients with chronic liver disease and scarring of the liver. We will look at changes in overall health, severity of symptoms, and progression of disease.
Study Topics
Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
Study Topics
Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
Study Topics
Women's Health and Future Pregnancies
The goal of this study is to learn how a woman's health, including what she eats and the activities she does, affects her and her baby if she gets pregnant. We are inviting women under 40 who are overweight or obese and might become pregnant to volunteer for this study. The study team will provide more details.
Study Topics
Healthy Volunteers Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Studying the Drug AOC 1001 for Patients with Myotonic Dystrophy Type 1
The purpose of this study is to learn more about the study drug AOC 1001. We want to see how safe and useful the study drug is for the treatment of myotonic dystrophy type 1.
Study Topics
Studying Risk Factors for Type 2 Diabetes in Youth
Type 2 diabetes is a health problem where the body has too much sugar in the blood. This study wants to find out what makes young people more likely to get this condition early. The information we learn will help us create future studies on how to stop and treat type 2 diabetes in young people.
Study Topics
Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
Study Topics
Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
Study Topics