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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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Studying Radiation Plus Immune Therapy for Kidney Cancer
The purpose of this study is to see if adding radiation to immune therapy helps people with kidney cancer that has spread. We want to see if this new treatment keeps the cancer from getting worse longer than immune therapy alone. The goal is to find out which treatment works better. We are looking for volunteers with kidney cancer that has spread, and surgery is not currently recommended.
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Studying How Cancer Treatment Affects Thinking and Movement
The purpose of this study is to find out if people are okay with taking physical and thinking tests before and after cancer treatment. The treatments, like chemotherapy and surgery, can change how your body works and how well you think. Some people get better faster than others, but we do not know why. By looking at your test results before and after treatment, the researchers can see how the treatment affected you.
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Treating Ovarian Cancer with Avutometinib and Defactinib
The purpose of this study is to compare the combination of the study drugs, avutometinib and defactinib, to the usual treatment for a type of cancer called low grade serous ovarian cancer.
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Studying Two Treatment Combinations for Advanced Breast Cancer
This study compares palazestrant plus ribociclib to letrozole plus ribociclib in people with hormone receptor-positive, HER2-negative advanced breast cancer. Researchers want to learn whether palazestrant plus ribociclib works better at slowing cancer growth and helping people live longer. They will also compare the safety of the two treatment combinations.
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Studying a New Treatment Plan for Patients with Large B-cell Lymphoma or Grade IIIB Follicular Lymphoma
We are looking for volunteers with Grade IIIB Follicular or Relapsed/Refractory Diffuse Large B-cell Lymphoma. The purpose of this study is to see if we can reduce the chance of your cancer growing or spreading by adding more treatment to the usual therapy. We are doing this study to see if this new approach is better or worse than the usual approach for patients who are getting CAR T-cell therapy.
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Studying Money Stress Among Patients with Leukemia
The purpose of this study is to see if helping people with money problems during cancer treatment can make them feel better and stay healthier. People in the study will answer questions about their health, feelings, and money. The goal is to find out if special help with money makes a difference.
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Studying the Drug JNJ 88549968 for Patients with Myeloproliferative Neoplasms
Myeloproliferative neoplasms are blood cancers caused by changes in bone marrow cells. This study aims to learn more about the drug JNJ-88549968 to treat these cancers. We want to find a safe dose and see how long it stays in the body and how the body reacts to it.
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Predicting AML Relapse with Blood Tests
Some patients with Acute Myeloid Leukemia who get a stem cell transplant might not get better. This study aims to create blood tests to predict which patients will relapse early. These tests check how certain white blood cells (T cells) work. If successful, these tests could help doctors decide the best treatment for patients.
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Comparing Bone Marrow Cancer Treatment Combinations
The purpose of this study is to find out which treatment works best for people who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The study compares different combinations of medicines to see which helps people the most. Researchers hope this will help improve care for people with this type of cancer.
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Studying Ablative Local Therapy for Colorectal Cancer
The purpose of this study is to learn if adding special tumor treatments, called ablative local therapy, can help people with colorectal cancer that has spread. These treatments may use surgery, radiation, or heat to target all tumor spots. The goal is to see if adding these treatments to usual cancer medicine helps people live longer.
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Studying a New Treatment Combination for Mantle Cell Lymphoma
The purpose of this study is to learn more about a new medicine combination to help patients with a type of blood cancer called mantle cell lymphoma. We want to see if a new medicine called sonrotoclax combined with the medicine zanubrutinib works better than zanubrutinib alone. Volunteers in the study will be randomly assigned to get either the new medicine or a placebo along with zanubrutinib.
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Studying Etentamig for Patients with Multiple Myeloma
The purpose of this study is to learn more about the medicine etentamig. We want to see if this medicine is safe and helpful for people with multiple myeloma. Our researchers will also study how the medicine works in the body, and what they learn may help improve future treatment for this cancer.
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Using Brain Scans to Help Predict Brain Cancer Changes
The purpose of this study is to learn how different brain scans can show changes in brain cancer. The goal is to see if special MRI and PET scans can give doctors better information than regular scans. This may help doctors understand how tumors grow and how patients respond to treatment. This study is for volunteers with glioblastoma that is IDH‑wild type.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying New Treatments for Advanced Breast Cancer
The purpose of this study is to learn more about a new drug, MK-2870, alone or with another drug called pembrolizumab. We want to see how well they work compared to standard chemotherapy. The goal is to find out which treatment helps people live longer and feel better. This study is for volunteers with advanced breast cancer that cannot be removed by surgery.
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Studying a New Medicine for B-cell Non-Hodgkin Lymphoma
The purpose of this study is to learn more about a new medicine called AZD0486. This medicine is for people with a type of cancer called B-cell non-Hodgkin lymphoma that has come back or did not get better with other treatments. The goal is to see if this medicine is safe and if it helps shrink or stop the cancer.
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Studying the Drug CB-011 for Treatment of Multiple Myeloma
The purpose of this study is to learn more about the study drug CB-01. We want to see if it is safe and helpful for treating people with a type of blood cancer called multiple myeloma that has come back or did not respond to other treatments. This drug uses special cells from a healthy donor to find and kill cancer cells.
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Studying the Medicine BLEXIMENIB for Patients with Acute Myeloid Leukemia
The purpose of this study is to learn more about a new medicine called BLEXIMENIB. We want to see if it works better when added to two other medicines for people with a kind of blood cancer called acute myeloid leukemia (AML). This study is for people with changes in the KMT2A or NPM1 gene, who are not able to get stronger chemotherapy.
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Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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