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Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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Studying the Drug REGN5678 for Patients with Prostate Cancer
The purpose of this study is to learn more about a treatment for patients with prostate cancer. We want to see if the study drug called REGN4336 is safe and useful for patients with castration-resistant prostate cancer that has spread to other parts of the body. Study team will provide more information.
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Studying Vitamin C Levels and Blood Cancer Treatment Outcomes
The purpose of this study is to see if vitamin C levels affect how well treatments work for people with certain types of blood cancer. We will also look at specific genes that might affect vitamin C in the body. This study will help us understand if vitamin C can improve treatment results for these cancers. We are looking for volunteers with acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia.
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Treating Neuroendocrine Carcinoma with Atezolizumab
The purpose of this study is to see if adding the study drug, atezolizumab, to the usual cancer treatment helps people with a type of cancer that starts outside the lungs called neuroendocrine carcinoma.
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Testing the Study Drug KTX-1001 for The Treatment of Multiple Myeloma
The goal of this study is to learn more about the study drug KTX-1001. We want to find out if this drug is safe for patients with multiple myeloma that has returned or didn't respond to treatment. We also want to see if patients can handle the taking the drug.
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Testing the Study Drug PRO1160 for Advanced Kidney, Throat, and Blood Cancers
The purpose of this study is to learn more about the new drug PRO1160. We want to see if it is safe and helpful for treating patients with cancer that didn't fully respond to treatment or has come back. Volunteers must have kidney cancer, throat cancer, or a type of blood cancer called non-Hodgkin lymphoma.
Study Topics
Cancer Cancer: Ear, Nose, Mouth, Throat Cancer: Kidney, Liver, Pancreas Cancer: Lymphoma
Testing the Study Drug INX-315 for Patients with Advanced Cancer
The purpose of this study is to learn more about the study drug INX-315. We want to see if this study drug is a safe treatment for patients with certain types of advanced cancer or cancer that has spread to other parts of the body. Study team will provide more information on eligibility criteria.
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A Study of the Drug ORIC-944 for Patients with Prostate Cancer
The purpose of this study is to learn more about the study drug ORIC-944. We want to see if this study drug is safe and useful to treat patients with prostate cancer that has spread to other areas of the body.
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Studying New Treatments for High-Risk Head and Neck Cancer
The purpose of this study is to find a new treatment for people with head and neck cancer. We want to see if using radiation therapy with two different mixes of drugs is better than the usual treatment. The first mix is radiation therapy with the drugs called docetaxel and cetuximab. The second mix is radiation therapy with the drug called cisplatin and an immunotherapy drug called atezolizumab. We are looking for volunteers who have had surgery to remove high-risk cancer in the mouth, throat, voice box, or lower throat.
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Comparing Treatments for Patients with Newly Diagnosed AML
The purpose of this study is to see how well the study drug, CPX-351 works for treating acute myeloid leukemia. We want to find out if this approach works better than the usual approach. We also want to learn more about the possible side effects of this treatment.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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Treating Neuroblastoma in Young People with Naxitamab
The purpose of this study is to test the safety and effectiveness of adding a new drug called naxitamab to the usual treatment for a type of cancer called neuroblastoma.
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Cancer Cancer: Head, Neck Cancer: Thyroid, Other Glands Children, Infants, Teen Health
Using Pre-operative Stereotactic Radiosurgery to Treat Brain Cancer
This study is about finding the best way to treat cancer that has spread to the brain. The study will help doctors learn if doing SRS before surgery is better, the same, or worse than doing it after surgery. The study will also look at the risks and benefits of both approaches.
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A Study of the Drug Odronextamab for Follicular Lymphoma
Follicular lymphoma is a kind of non-Hodgkin lymphoma. This study wants to learn more about the drug Odronextamab for this disease. We want to see if the drug is safe and okay for patients who haven't been treated before. We also want to find out about any side effects the drug might cause.
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Learning More about Sleep Problems Among Lung Cancer Survivors
The purpose of this study is to learn more about sleep problems among patients who have had lung cancer. We want to better understand how to find and help address sleep problems by asking questions about how sleep affects patients' health and feelings. The goal is to find better ways to help our patients sleep.
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Predicting AML Relapse with Blood Tests
Some patients with Acute Myeloid Leukemia who get a stem cell transplant might not get better. This study aims to create blood tests to predict which patients will relapse early. These tests check how certain white blood cells (T cells) work. If successful, these tests could help doctors decide the best treatment for patients.
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Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
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Studying Genes and Weight Loss in Patients with Pancreatic Cancer
The purpose of this study is to understand how genes are related to weight loss in people with pancreatic cancer. Weight loss is a common issue for those with pancreatic cancer and can make life more difficult and treatments less useful. We hope to learn how to better treat and help future patients. We are seeking volunteers who have pancreatic cancer that has spread and cannot be removed by surgery.
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Understanding Cancer Fatigue in Survivors
Cancer-related tiredness is a common issue for people who have cancer or have been treated for it. This study aims to understand how cancer survivors and their doctors discuss this tiredness. We want to make a useful poster for exam rooms to improve talking about, diagnosing, and treating this tiredness. We are seeking cancer survivor volunteers who have had at least 1 visit with the Supportive Oncology team at Levine Cancer Institute or the Charlotte or Winston-Salem campus of Atrium Health Wake Forest Baptist Comprehensive Cancer Center. This study will last around 6 months.
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Testing New CAR T-Cell Therapy for Lymphoma
The purpose of this study is to learn more about the study drug, named PMB-CT01, also known as BAFFR-CAR T cells. We want to see if this study drug is safe and useful to treat people with B-cell Non-Hodgkin Lymphomas.
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