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Testing the Study Drug Cabozantinib for Kids and Teens with Bone Cancer
The purpose of this study is to test the study drug cabozantinib. We want to see if this study drug helps kids and young adults with a type of bone cancer called osteosarcoma. We will compare cabozantinib with standard care to check if it works better and check to see if it safe. We are looking for volunteers with remaining cancer that cannot be removed by surgery after using chemotherapy treatment. The study team will provide more information.
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Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
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Studying the Drug ABBV-453 for Patients with Lymphocytic Leukemia
The purpose of this study is to learn more about the study drug ABBV-453. We want to find a safe and tolerable dose of this study drug in patients with chronic lymphocytic lymphoma or small lymphocytic lymphoma. We also want to see how the drug interacts with your body.
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Testing the Study Drug ABBV-383 for Patients with Multiple Myeloma
The goal of this study is to learn more about the drug ABBV-383. We want to find out if this drug is safe, helpful, and easy to handle when given to adults whose multiple myeloma has returned or didn't improve.
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Checking for AL Amyloidosis among Patients with Smoldering Multiple Myeloma
Smoldering Multiple Myeloma is a blood disorder that can become a more serious cancer called multiple myeloma. This study aims to find out if checking for certain genes is connected to the development of AL amyloidosis in people aged 40 or older with this disorder.
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Testing Cancer Drug Doses for Older Adults with Breast Cancer
The purpose of this study is to test two cancer drugs, palbociclib and ribociclib. We want to find the best dose for older adults with breast cancer. We want to help patients stay on treatment longer with fewer side effects. The study is for volunteers with hormone receptor-positive, HER2-negative breast cancer that has spread to another part of the body.
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Testing the Study Drug XmAb819 for Patients with Kidney Cancer
The purpose of this study is to test a new drug called XmAb819. We want to see if this study drug is safe and works well for volunteers with clear cell renal cell carcinoma that has come back or not responded to other treatments.
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Studying the Drug SGR3515 for Patients with Advanced Solid Tumors
The study aims to learn about the drug SGR-3515. We want to see if it is safe and works well for treating advanced solid tumors. We also want to find the best dose and schedule for treating your cancer. We are looking for volunteers with advanced solid tumors who have either stopped benefiting from or cannot tolerate previous treatments, or whose cancer has returned.
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Studying the Drug MM-1-104 for People with Advanced or Spreading Cancer
The purpose of this study is to test a new drug called IMM-1-104. We want to see if this study drug is safe and useful for people with advanced or spreading cancer. The drug aims to stop cancer growth.
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Learning About Tiredness in Lung Cancer Patients
We want to understand why people with a type of lung cancer feel tired. We also want to know if exercise can help and how caregivers can support patients in staying active. We need volunteers who have a type of lung cancer called non-small cell lung cancer or are caregivers for someone with it.
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Testing the Study Drug Nivolumab for Patients with Multiple Myeloma
The goal of this study is to learn more about the study drug nivolumab. We want to find out if this drug is safe and helpful for people with multiple myeloma that has returned and isn't responding to other treatments. People who want to join this study must have already tried another drug called idecabtagene vicleucel.
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Studying Opioid Use After Cancer Surgery
The purpose of this study is to see how many pain pills are taken by cancer patients after surgery. We also want to see how patients get rid of leftover pills and how happy they are with their care. We are looking for volunteers who are already scheduled to have surgery to remove their bladder, kidney, or prostate because of cancer at Atrium Health Wake Forest Baptist Comprehensive Cancer Center.
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Cancer Cancer: Kidney, Liver, Pancreas Cancer: Prostate Cancer: Urinary and Bladder
Testing Two Treatments for Prostate Cancer
The purpose of this study is to test two treatments for prostate cancer. We will compare Docetaxel alone to Docetaxel plus Radium-223. We want to see which treatment works better for men with advanced prostate cancer that has spread to bones. This study will help doctors find out which treatment helps patients live longer and feel better.
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Testing New Lymphoma Treatment Combinations
The purpose of this study is to test if different drug combinations are safe and work well for treating lymphoma. We want to see how your body processes these drugs and what effects they have on your cancer. We are testing two combinations: mosunetuzumab with CC-220 or CC-99282, and glofitamab with obinutuzumab and CC-99282. We will use different doses and schedules to see what works best.
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Comparing Different Treatments for Patients with Blood Cancer
The purpose of this study is to test two drug combinations for people with a type of blood cancer called Waldenström's Macroglobulinemia or Lymphoplasmacytic Lymphoma. We want to see if the new drug combination is safe and helps fight the cancer. The study is for volunteers who have not been treated for this cancer before.
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Studying a New Biomarker to Predict Breast Cancer Return
The goal of this study is to learn more about a new test called Oncodetect™. This test looks for signs of breast cancer in the blood. We want to see how well this test can find cancer coming back during and after treatments like surgery or radiation.
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Testing the Study Drug Xaluritamig for Prostate Cancer Patients
The purpose of this study is to learn more about the study drug Xaluritamig. We want to see if this study drug is safe and useful to treat patients with prostate cancer that has come back after their main treatment.
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Using Stereotactic Body Radiation Therapy to Treat Lung Cancer
The purpose of this study is to compare the usual treatment alone to using an additional treatment called Stereotactic Body Radiation Therapy plus the usual treatment.
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A Study of the Drug Acalabrutinib for Mantle Cell Lymphoma Treatment
The purpose of this study is to learn more about the study drug Acalabrutinib. We want to see if this study drug can be effective for mantle cell lymphoma when combined with the standard of care treatment. We also want to find out the side effects of this study drug.
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Testing the Study Drug Olvi-Vec for Ovarian Cancer that Resists Treatment
The purpose of this study is to learn about the drug Olvi-Vec. We want to see if it is safe and helpful for treating ovarian, fallopian tube, or peritoneal cancer that did not get better with a type of treatment called platinum-based chemotherapy.
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