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Comparing Bone Marrow Cancer Treatment Combinations
The purpose of this study is to find out which treatment works best for people who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The study compares different combinations of medicines to see which helps people the most. Researchers hope this will help improve care for people with this type of cancer.
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Study of a New Medicine for Early Primary Myelofibrosis
Primary myelofibrosis is a rare, chronic blood cancer. The purpose of this study is to learn more about a new medicine for patients with early or low risk primary myelofibrosis. Our researchers want to see if the medicine is safe and works well for patients.
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Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
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Studying a New Treatment Combination for Mantle Cell Lymphoma
The purpose of this study is to learn more about a new medicine combination to help patients with a type of blood cancer called mantle cell lymphoma. We want to see if a new medicine called sonrotoclax combined with the medicine zanubrutinib works better than zanubrutinib alone. Volunteers in the study will be randomly assigned to get either the new medicine or a placebo along with zanubrutinib.
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Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
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Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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Studying Etentamig for Patients with Multiple Myeloma
The purpose of this study is to learn more about the medicine etentamig. We want to see if this medicine is safe and helpful for people with multiple myeloma. Our researchers will also study how the medicine works in the body, and what they learn may help improve future treatment for this cancer.
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Using Brain Scans to Help Predict Brain Cancer Changes
The purpose of this study is to learn how different brain scans can show changes in brain cancer. The goal is to see if special MRI and PET scans can give doctors better information than regular scans. This may help doctors understand how tumors grow and how patients respond to treatment. This study is for volunteers with glioblastoma that is IDH‑wild type.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying New Treatments for Advanced Breast Cancer
The purpose of this study is to learn more about a new drug, MK-2870, alone or with another drug called pembrolizumab. We want to see how well they work compared to standard chemotherapy. The goal is to find out which treatment helps people live longer and feel better. This study is for volunteers with advanced breast cancer that cannot be removed by surgery.
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Studying an Exercise Program for Teens and Young Adults After Cancer Treatment
The purpose of this study is to find the best ways to help Hispanic or Latino/a teens and young adults who had cancer stay physically active at home. We will use a program that uses a Fitbit and social media to encourage exercise. The goal is to make sure the program fits the language and culture of the participants.
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Cancer Cancer: Children, Teens Children, Infants, Teen Health
Studying Care Choices After Breast Cancer Surgery
The purpose of this study is to compare two different approaches to care for breast cancer after surgery. Our researchers want to find out whether closely monitoring patients after surgery works just as well as giving additional medication to prevent the cancer from returning. This study is for volunteers who had triple-negative breast cancer and showed no signs of cancer after completing chemotherapy and surgery. The results will help doctors determine the best way to care for patients in this situation.
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Studying a New Medicine for B-cell Non-Hodgkin Lymphoma
The purpose of this study is to learn more about a new medicine called AZD0486. This medicine is for people with a type of cancer called B-cell non-Hodgkin lymphoma that has come back or did not get better with other treatments. The goal is to see if this medicine is safe and if it helps shrink or stop the cancer.
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Studying Radiation vs Usual Care for Cancer that Spread to Bones
The purpose of this study is to help patients who have cancer that has spread to their bones but is not causing pain yet. We want to find out if giving radiation therapy before symptoms start can help prevent problems from bone cancer. Volunteers in this study will either get the usual care or the usual care plus radiation. The goal is to see which option works better to stop bone problems like fractures or spinal cord issues.
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Cancer Cancer: Men's Cancer Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Solid Tumor Cancer: Women's Cancer
Studying the Drug CB-011 for Treatment of Multiple Myeloma
The purpose of this study is to learn more about the study drug CB-01. We want to see if it is safe and helpful for treating people with a type of blood cancer called multiple myeloma that has come back or did not respond to other treatments. This drug uses special cells from a healthy donor to find and kill cancer cells.
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Studying the Medicine Erdafitinib for Brain Cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
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Studying the Medicine BLEXIMENIB for Patients with Acute Myeloid Leukemia
The purpose of this study is to learn more about a new medicine called BLEXIMENIB. We want to see if it works better when added to two other medicines for people with a kind of blood cancer called acute myeloid leukemia (AML). This study is for people with changes in the KMT2A or NPM1 gene, who are not able to get stronger chemotherapy.
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Studying the Supplement Fisetin to Help Cancer Survivors with Tiredness
The purpose of this study is to learn more about fisetin, a dietary supplement. We want to find out if this supplement can help reduce tiredness in people who have had cancer treatments. We will compare this supplement to a placebo. We are looking for volunteers who previously had cancer treatments that often cause tiredness. The study team will provide more information.
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Studying New Drug Combinations for Advanced Small Cell Lung Cancer
The purpose of this study is to find the highest safe dose of a new drug, iadademstat, when used with other cancer drugs (atezolizumab or durvalumab) in people with advanced small cell lung cancer. The study will check for side effects and see how well the drug combination works. This may help doctors learn if this new treatment is better or worse than the usual care for this cancer.
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Early Detection Matters
The purpose of this study is to test recruitment methods to find and sign up people for a blood screening study. The results will help us decide if we can do a bigger study later. You are invited to join because you are at least 30 years old, self-identify as Black and/or African American or are at higher risk for developing MGUS because of a first-degree relative and, live in Charlotte, NC or nearby. This study will also check how many people have a blood condition that might lead to blood cancer.
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Minority Health Screening and Prevention Cancer Cancer: Blood
Finding the Best Blood Cancer Treatment Using Blood Tests
The purpose of this study is to find out if doctors can quickly test blood and bone marrow to look for signs that help choose the best cancer treatment. These signs, called markers, can show which treatments might work best. If your test shows certain markers, you might be able to join a special treatment group. If not, your doctor will give you the usual care. We are looking for volunteers who have previously untreated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
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