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Using Anifrolumab to Treat Lupus Nephritis
The purpose of this study is to learn more about a new lupus nephritis treatment called Anifrolumab. We want to find out how well it works and what side effects it may have.
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Comparing Ways to Improve Blood Flow in Newborns' Lungs
The purpose of this study is to looks at two different methods to help increase blood flow in the lungs of newborn babies. One method uses a shunt, which is a small tube, and the other uses a stent, which is a tiny mesh-like device. We want to learn if one of the two options is better than the other.
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Testing a New Study Device for Mitral Valve Dysfunction
The purpose of this study is to test a new study device called the Cephea Mitral Valve System for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
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Testing a New Study Device for Patients with Heart Failure
The purpose of this study is to test a new study device called the CCM-D System. We want to see if this device is safe and effective for patients with heart failure and a heart that is not pumping out as much blood as it should with each beat.
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Looking Into the Need of Blood Thinners as Treatment for Atrial Fibrillation
Blood thinning drugs are usually used to treat atrial fibrillation. Atrial fibrillation is when the heart has an irregular and often very fast heart rhythm. Blood thinners lower the risk of stroke but also increase the risk of bleeding. It may not be necessary for people who have short or infrequent atrial fibrillation to take blood thinners. The purpose of this study is to find out if it is safe to stop blood-thinning medication during long periods of normal heart rhythm.
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Finding Out How Well the Study Drug, HU6, Works for Treating Patients with Obesity and Heart Failure
The purpose of this study is to learn more about the study drug, HU6. The study will help us find out how the study drug affects weight loss and the ability to exercise. It will also help us see what side effects may be caused by the study drug.
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Can Physical Activity Be Helpful for Lymphoma Patients During Treatment
The purpose of this study is to find out if exercise or educational classes can be helpful for lymphoma patients. We want to know if exercise or classes can help patients keep their quality of life and ability to exercise. We also want to know if exercise or classes can help lymphoma patients with memory and heart health.
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Testing a Study Device for Treatment of Sudden Tear in the Aorta
The purpose of this study is to find out if the study device called AMDS is safe and works well for treating this condition. We want to see if this device can help heal the aorta's walls and reduce the need for surgery.
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Studying the EXCOR® Active Driving Unit for Children in Need of a Device to Help their Heart Pump Blood
The purpose of this study is to learn more about the EXCOR® Active Driving Unit, which is a study device used with the EXCOR®. We want to test the safety and benefit of this study device among children with a heart that is having trouble pumping and supplying blood to the rest of the body and is in need of a device to assist the pumping of the heart.
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Testing a Study Device for Chronic Venous Insufficiency
Chronic venous insufficiency happens when blood gets stuck in the veins of the legs because the valves do not work right. This study wants to see if the study device Venclose™ digiRF™ Generator and its catheters are safe and good at treating this problem. We want to know if these devices can help fix the veins in the legs and stop them from leaking. The study will also check if the devices are safe to use.
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Study of Bempedoic Acid for Treating High Cholesterol in Children
Heterozygous familial hypercholesterolemia (HeFH) is an inherited genetic disorder. It causes dangerously high cholesterol levels. This study will see if bempedoic acid works at lowering cholesterol in kids with HeFH. Bempedoic has been tested in adults, but it has not been tested in children or young adults yet.
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Testing Cardiac Rehab for Amyloidosis
The study aims to find out if exercise programs can help people with this condition feel better.
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Comparing MitraClip and Surgery for Mitral Valve Repair
The purpose of this study is to test a study device called the MitraClipTM Device for patients with this condition and who are at moderate risk of surgery.
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Using the GORE® Device to Treat Heart Lesions
Aortic disease may cause wounds in the blood vessels near the heart. We want to learn more about the safety and how well the study device, GORE® Ascending Stent Graft, treats these wounds.
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Study on Statin Use in Older Adults
Statins are medicines that lower bad cholesterol in the body. They help prevent heart attacks and strokes. This study wants to find out if taking statins can help older adults live longer and healthier by preventing dementia, disability, or heart disease.
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Aging Healthy Volunteers Heart Health Screening and Prevention
Studying the GORE® VIAFORT Vascular Stent for Treating Reduced Blood Flow in the Inferior Vena Cava
The purpose of this study is to learn more about the study device called GORE® VIAFORT Vascular Stent. We want to see if this study device can help treat blocked blood vessels in the abdomen that carry blood back to the heart from the legs and organs, known as iliocaval venous disease. We also want to see how safe the study device is and how it works for this type of disease.
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Testing the Study Device Impella for Patients with Severe Heart Disease
The purpose of this study is to learn more about the study device called Impella. We want to see if this device can be used during a high-risk heart procedure in patients with weak heart function on the left side. We want to learn if this device will improve symptoms and heart function after the procedure when compared to the standard of care treatment.
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Studying Causes of Heart Failure
This purpose of this study is to understand what causes heart failure. Some people with early-stage heart failure might not know they have it because they feel fine, while others may have many or few symptoms. We want to learn why some people get heart failure and how to better classify it for targeted treatments. We are recruiting volunteers with and without heart failure to learn more.
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Testing Different Treatments for Abdominal Aortic Aneurysms
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
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Studying the Drug Metformin for Older Patients with Heart Failure
This study wants to see if the medicine Metformin XR can help older people with this heart problem. We also want to learn about the side effects and see if it can make their health better.
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