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Studying a New Medicine for Muscle Weakness Diseases
The purpose of this study is to see if a new medicine called anifrolumab helps people with muscle weakness diseases called polymyositis and dermatomyositis. The medicine will be given as a shot under the skin, along with regular treatment. The study will check if this medicine helps people feel better and need less of their usual medicine.
Study Topics
Movement Disorder Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Studying a New Treatment Plan for Relapsing Multiple Sclerosis
The purpose of this study is to learn more about a new treatment plan for patients with relapsing multiple sclerosis. We want to see if a new way of giving the medicine ofatumumab every two months is safe and works like the regular monthly dose. Our researchers will check how the medicine affects certain cells and proteins in the blood.
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Learning More about Eye Movement among ALS Patients
The purpose of this study is to learn how ALS, a disease that affects nerve cells, changes the way people move their eyes. What the researchers learn from this study could help make better tools for people with ALS. We also hope to help doctors track the disease more easily and learn more about how ALS develops. The researchers plan to share what they find so it can help people living with ALS, their caregivers, and other scientists.
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Studying a New Medicine for Generalized Myasthenia Gravis
Acetylcholine receptor antibody positive generalized myasthenia gravis (AChR+ gMG) is a disease where the body's immune system attacks the places where nerves talk to muscles, making the muscles weak and tired. The purpose of the study is to learn more about a new medicine and see how well it helps people in their everyday activities.
Study Topics
Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
Using a Small Device to Track Muscle Changes in ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that slowly makes muscles weaker and harder to control, making it tough to walk, talk, or breathe. The purpose of this study is to see how a small device called the mScan can measure muscle changes in people with ALS. The device uses a tiny, painless electrical signal to check muscles. Our researchers hope this will help track ALS over time and see how well treatments work.
Study Topics
Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles
Studying the Medicine CREXONT for Parkinson's Disease
The purpose of this study is to learn more about the medicine CREXONT. We want to see if this medicine is safe and useful for patients with Parkinson's disease in their daily lives.
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Understanding How Breast Size Affects Migraine Headaches
The purpose of this study is to find out if breast tissue affects headache and neck pain. Some studies show that having large breasts might be linked to pain in the head and neck, but we do not fully understand the reasons for this. In this study, we will monitor how headache features change before and after plastic surgery. We are looking for volunteers who are seeing Plastic Surgery for breast reduction (reduction mammoplasty) or excess skin removal (panniculectomy) procedures.
Study Topics
Studying the Drug VX-670 for Adults with Myotonic Dystrophy Type 1
The purpose of this study is to learn more about the study drug VX-670. We want to find out if it is safe and if adults with myotonic dystrophy type 1 can handle it well.
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Testing a New Formula of Cladribine for Patients with Generalized Myasthenia Gravis
Generalized myasthenia gravis is a condition where the body's defense system attacks the muscles, making them weak and tired. The purpose of this study is to find out how well a new medicine called Cladribine works compared to a fake medicine. We also want to see how well patients can handle the new medicine.
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Studying the Medicine Apitegromab for Babies with Muscle Weakness
Spinal muscular atrophy is a disease that makes muscles weak and hard to move. The purpose of this study is to test a new medicine called apitegromab. We want to see if it is safe and helpful for babies under 2 years old who still have trouble moving even though they already got another treatment called survival motor neuron therapy.
Study Topics
Genetic Disorders Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles Children, Infants, Teen Health
Comparing Different Migraine Medicines
The purpose of this study is to learn more about three migraine medicines: atogepant, propranolol, and topiramate. Our researchers want to see which one helps prevent migraines the best. Volunteers in the study will try one medicine and keep track of their headaches. The results will help doctors and patients choose the best medicine for migraine prevention.
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Learning About Patient Experiences with HyQvia for Nerve Disease
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a long-term illness where the body's defense system attacks the nerves, making people feel weak and numb. This study aims to learn about the experiences of people with this disease who are using a medicine called HyQvia. We want to understand their symptoms, how the disease affects their daily lives, and their treatment experiences. The information we gather may help others in the future by improving our understanding of CIDP and making future research studies better.
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Study to See How Well the Study Drug EPX-100 Works for Treating Dravet Syndrome
The purpose of this study is to see how well the study drug, EPX-100, works for treating Dravet syndrome. We also want to learn more about possible side effects.
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Studying New Ways to Reduce Caregiver Stress
The purpose of this study is to see if listening to nature sounds and using a new technology called CR can help people who take care of loved ones feel less stressed. Taking care of someone can be stressful and affect your health. This study will test if CR can help reduce stress symptoms like anxiety, trouble sleeping, and changes in heart rate in a small group of people.
Study Topics
Healthy Volunteers Mental Health Neurology Disorders Sleep Brain and Memory
Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
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Learning More About Treating Childhood Absence Epilepsy and Juvenile Absence Epilepsy with Brivaracetam
The purpose of this study is to see how well the study drug, brivaracetam, treats childhood absence epilepsy or juvenile absence epilepsy. We also want to learn more about any possible side effects it may cause.
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How Myotonic Dystrophy Type 2 Affects the Brain
Myotonic dystrophy affects the muscles and other body systems. The purpose of this study is to look at the impact myotonic dystrophy type 2 has on the brain. We also want to look at brain-based symptoms like problems with thinking, memory or motivation.
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Studying CereGate Therapy in Patients Diagnosed with Parkinson's Disease
The purpose of this study is to learn more about a new therapy called CereGate. We want to see if this type of therapy can reduce freezing movements in patients with Parkinson's Disease.
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How the Brain Makes Decisions in Patients with Parkinson's Disease
The purpose of this study is to look at how the brain responds to information when it comes to decision making.
Study Topics