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Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
Study Topics
Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
Study Topics
Finding the Best Blood Cancer Treatment Using Blood Tests
The purpose of this study is to find out if doctors can quickly test blood and bone marrow to look for signs that help choose the best cancer treatment. These signs, called markers, can show which treatments might work best. If your test shows certain markers, you might be able to join a special treatment group. If not, your doctor will give you the usual care. We are looking for volunteers who have previously untreated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
Study Topics
Stem Cell Transplant After Chemotherapy for Lymphoma Patients
Generalized myasthenia gravis is a condition where the body's defense system attacks the muscles, making them weak and tired. The purpose of this study is to find out how well a new medicine called Cladribine works compared to a fake medicine. We also want to see how well patients can handle the new medicine.
Study Topics
Studying Cirtuvivint for Blood Cancer
The purpose of this study is to learn more about a medicine called cirtuvivint for certain blood cancers. Our researchers will study this medicine by itself or together with another pill called ASTX727. We want to learn how safe these medicines are, find the best dose, and see how they affect the cancer. This study is for volunteers with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML).
Study Topics
Studying a New Medicine for Polycythemia Vera
Polycythemia vera is a blood disease where the body makes too many red blood cells. The purpose of this study is to learn more about a new medicine called DISC 3405 for this disease. Our researchers will look at how the medicine works in the body and what dose works best.
Study Topics
Studying New Treatments for Children and Young Adults With Relapsed B-ALL
The purpose of this study is to look at a new way to treat a blood cancer called B-ALL that has come back after prior treatment. Researchers will see if the medicine combination of blinatumomab and nivolumab is more effective than blinatumomab alone. The goal is to find safer treatments that help people stay healthy longer.
Study Topics