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Use of a Bone Marrow Transplant for Patients with Severe Aplastic Anemia
The purpose of this study is to help people with severe aplastic anemia, a condition where the body does not make enough blood cells. We want to see if a bone marrow transplant can be a safe and useful first treatment for patients with this condition, even if they have not tried other treatments before. This could improve their chances of recovery and lead to better health outcomes.
Study Topics
Studying Axatilimab for Children and Teens with Chronic Graft‑Versus‑Host Disease
Chronic graft‑versus‑host disease (GVHD) is a condition where donated stem cells attack the patient's body after a transplant, causing ongoing health problems. The purpose of this study is to learn more about the medicine axatilimab for children and teens with this condition. The goal is to see if this treatment works better and is safe compared to other medicines already used.
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Testing the Study Drug AJ1-11095 for Patients with Myelofibrosis
The goal of this study is to learn more about a drug called AJ1-11095. We want to find out if this drug is safe and helpful for people with a blood and bone marrow disease called myelofibrosis. To join the study, you must have already taken a medicine called a type I JAK2 inhibitor, but still have a big spleen and symptoms from myelofibrosis.
Study Topics
Studying the Drug SNDX-5613 for Patients with Acute Myeloid Leukemia
The study aims to learn more about the drug SNDX-5613. We want to find the best dose for patients with a blood cancer called acute myeloid leukemia. We also want to see how this drug works when used with two other drugs, daunorubicin and cytarabine.
Study Topics
Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Helping Myeloma Patients Stay Healthy After CAR-T Therapy
The purpose of this study is to learn more about a medicine called iberdomide. We want to see if it is safe to take after a certain cancer treatment called CAR-T. Researchers want to know if this medicine can help keep multiple myeloma from coming back. They also want to see if this new treatment works better than just watching the cancer without giving more medicine.
Study Topics
Comparing a New Treatment For Blood Cancer Patients
The purpose of this study is to learn about a new treatment called Inotuzumab Ozogamicin. We want to see if it helps people with blood cancer. We will compare the results of patients who get this new treatment with those who get the usual treatment. We are looking for volunteers who are newly diagnosed with one of these blood cancers: high-risk B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia (MPAL), or disseminated B lymphoblastic lymphoma (B-LLy).
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Cancer: Leukemia